【代偿性肝硬化不同分期的临床研究进展】。

Q3 Medicine
Y P Wang, X H Yang, H Y Cai, P Zhou, X P Tang, X Y Xu, Y J Guan
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引用次数: 0

摘要

2021年版的BavenoⅦ门静脉高压共识和欧洲肝脏研究协会2023年指南将再代偿性肝硬化定义为在有效治疗肝硬化潜在病因后,肝功能恢复和稳定、肝纤维化改善和长期无失代偿性肝硬化。随着肝硬化患者的逐渐增多,代偿性肝硬化已成为该领域一个重要的研究方向。根据不同的代偿阶段,肝硬化患者可分为暂时性代偿、稳定性代偿和长期代偿三个阶段。不同分期的临床特征及预后有显著差异。暂时代偿期患者病情波动大,稳定性差,并发症复发风险高。稳定代偿期患者的预后受初始失代偿事件的原因和类型的影响显著,而长期代偿期患者的病情较为稳定,远期预后接近代偿性肝硬化。本文旨在总结和探讨肝硬化不同阶段的再补偿率、各种并发症及肝癌的发生风险、再补偿后的长期管理和治疗,为今后该领域的研究提供新的方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Clinical research progress in different stages of recompensated cirrhosis].

The 2021 version of the Baveno Ⅶ consensus on portal hypertension and the 2023 guidelines from the European Association for the Study of the Liver define recompensated cirrhosis as the restoration and stabilization of liver function, improvement of liver fibrosis, and absence of decompensated cirrhosis for a long time following effective treatment of the underlying etiology of cirrhosis. Recompensated cirrhosis has become an important research direction in the field with the gradually increasing number of these patients. Temporary recompensation, stable recompensation, and long-term recompensation are the three stages into which patients with cirrhosis are divided, based on varying recompensation stages. Clinical characteristics and prognosis are significantly different among different stages. Patients in the temporary compensation stage have significant fluctuations in their condition and poor stability, with a high risk of recurrent complications. The prognosis of patients in the stable recompensation stage is significantly affected by the cause and the type of initial decompensation event, while the condition of patients in the long-term recompensation stage is more stable, and the long-term prognosis is close to that of compensated cirrhosis. This article aims to summarize and explore the recompensation rates at different stages of liver cirrhosis, the occurrence risk of various complications and liver cancer, and long-term management and treatment following recompensation, providing new directions for future research in this field.

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来源期刊
中华肝脏病杂志
中华肝脏病杂志 Medicine-Medicine (all)
CiteScore
1.20
自引率
0.00%
发文量
7574
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