{"title":"一氧化氮、前列腺素、血栓素和内皮素在肺癌中的作用综述。","authors":"Sadettin Demirel, Ipek Nazli Sinag","doi":"10.12998/wjcc.v13.i25.107907","DOIUrl":null,"url":null,"abstract":"<p><p>Lung cancer is the most frequent cause of cancer-related mortality worldwide. Nitric oxide (NO), prostaglandins (PGs), thromboxanes (TXs), and endothelins (ETs) participate in numerous physiological processes. These agents play an important role in lung carcinogenesis by regulating cancer cell proliferation, apoptosis, invasion, and angiogenesis. NO is a gaseous free radical with tumoricidal and tumorigenic activities in lung cancer. Arachidonic acid-derived PGs, including PGD<sub>2</sub>, PGE<sub>2</sub>, 8-iso-PGF<sub>2α</sub>, and PGI<sub>2</sub>, are related to the development of lung cancer. PGD<sub>2</sub> and PGI<sub>2</sub> act as tumor suppressors, while PGE<sub>2</sub> and 8-iso-PGF<sub>2α</sub> promote tumor progression. TXA<sub>2</sub> catalyzed by cyclooxygenase induces proliferation as well as angiogenesis. Elevated levels of TXB<sub>2</sub>, an inactive metabolite of TXA<sub>2</sub>, are positively correlated with lung carcinoma stages. ET-1 and ET-2 are 21 amino acid polypeptides; their silencing hinders lung cancer cell proliferation and invasion. ET-2 depletion also triggers apoptotic death. This chapter review aims to provide a comprehensive overview of the role of NO, PGs, TXs, and ETs in lung cancer.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 25","pages":"107907"},"PeriodicalIF":1.0000,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12243923/pdf/","citationCount":"0","resultStr":"{\"title\":\"Role of nitric oxide, prostaglandins, thromboxanes and endothelins in lung cancer: An overview.\",\"authors\":\"Sadettin Demirel, Ipek Nazli Sinag\",\"doi\":\"10.12998/wjcc.v13.i25.107907\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Lung cancer is the most frequent cause of cancer-related mortality worldwide. Nitric oxide (NO), prostaglandins (PGs), thromboxanes (TXs), and endothelins (ETs) participate in numerous physiological processes. These agents play an important role in lung carcinogenesis by regulating cancer cell proliferation, apoptosis, invasion, and angiogenesis. NO is a gaseous free radical with tumoricidal and tumorigenic activities in lung cancer. Arachidonic acid-derived PGs, including PGD<sub>2</sub>, PGE<sub>2</sub>, 8-iso-PGF<sub>2α</sub>, and PGI<sub>2</sub>, are related to the development of lung cancer. PGD<sub>2</sub> and PGI<sub>2</sub> act as tumor suppressors, while PGE<sub>2</sub> and 8-iso-PGF<sub>2α</sub> promote tumor progression. TXA<sub>2</sub> catalyzed by cyclooxygenase induces proliferation as well as angiogenesis. Elevated levels of TXB<sub>2</sub>, an inactive metabolite of TXA<sub>2</sub>, are positively correlated with lung carcinoma stages. ET-1 and ET-2 are 21 amino acid polypeptides; their silencing hinders lung cancer cell proliferation and invasion. ET-2 depletion also triggers apoptotic death. This chapter review aims to provide a comprehensive overview of the role of NO, PGs, TXs, and ETs in lung cancer.</p>\",\"PeriodicalId\":23912,\"journal\":{\"name\":\"World Journal of Clinical Cases\",\"volume\":\"13 25\",\"pages\":\"107907\"},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2025-09-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12243923/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"World Journal of Clinical Cases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.12998/wjcc.v13.i25.107907\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"World Journal of Clinical Cases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.12998/wjcc.v13.i25.107907","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Role of nitric oxide, prostaglandins, thromboxanes and endothelins in lung cancer: An overview.
Lung cancer is the most frequent cause of cancer-related mortality worldwide. Nitric oxide (NO), prostaglandins (PGs), thromboxanes (TXs), and endothelins (ETs) participate in numerous physiological processes. These agents play an important role in lung carcinogenesis by regulating cancer cell proliferation, apoptosis, invasion, and angiogenesis. NO is a gaseous free radical with tumoricidal and tumorigenic activities in lung cancer. Arachidonic acid-derived PGs, including PGD2, PGE2, 8-iso-PGF2α, and PGI2, are related to the development of lung cancer. PGD2 and PGI2 act as tumor suppressors, while PGE2 and 8-iso-PGF2α promote tumor progression. TXA2 catalyzed by cyclooxygenase induces proliferation as well as angiogenesis. Elevated levels of TXB2, an inactive metabolite of TXA2, are positively correlated with lung carcinoma stages. ET-1 and ET-2 are 21 amino acid polypeptides; their silencing hinders lung cancer cell proliferation and invasion. ET-2 depletion also triggers apoptotic death. This chapter review aims to provide a comprehensive overview of the role of NO, PGs, TXs, and ETs in lung cancer.
期刊介绍：
The World Journal of Clinical Cases (WJCC) is a high-quality, peer reviewed, open-access journal. The primary task of WJCC is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of clinical cases. In order to promote productive academic communication, the peer review process for the WJCC is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJCC are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in clinical cases.
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