Adenoid cystic carcinoma of the Bartholin's gland: Two case reports and review of literature.

Background: Adenoid cystic carcinoma (ACC) of the Bartholin's gland represents an exceptionally rare malignancy with limited documented cases in the medical literature. It typically manifests as a solid mass that clinically warrants suspicion for neoplastic processes.

Case summary: This case series details two cases of primary ACC cases involving the Bartholin's gland treated with radical surgical resection of the vaginal lesions. Notably, divergent therapeutic approaches resulted in contrasting prognoses: The patient receiving adjuvant radiotherapy following surgery maintained disease-free status with no locoregional recurrence or metastatic progression through 58 months of surveillance. Conversely, the non-radiated patient experienced disease recurrence within 18 months postoperatively.

Conclusion: Our findings suggest that postoperative radiation therapy may significantly decrease local recurrence rates in Bartholin's gland ACC, potentially influencing long-term disease control. This comparative outcome analysis underscores the importance of integrating adjuvant radiotherapy integration into treatment protocols for this rare malignancy.