涎腺基底细胞腺瘤中s100阳性基质的研究进展及展望

IF 3.1 3区医学 Q1 PATHOLOGY

Virchows Archiv Pub Date : 2025-09-03 DOI:10.1007/s00428-025-04240-0

Eiichi Sasaki, Katsuhiro Masago, Yasuko Fujita

{"title":"涎腺基底细胞腺瘤中s100阳性基质的研究进展及展望","authors":"Eiichi Sasaki, Katsuhiro Masago, Yasuko Fujita","doi":"10.1007/s00428-025-04240-0","DOIUrl":null,"url":null,"abstract":"Basal cell adenoma (BCA) with S100-positive stroma exhibits tricellular differentiation, consisting of bilayered epithelial cells and S100-positive spindle-shaped stromal cells. While the neoplastic nature of the stromal component has been supported by multiple lines of evidence, its myoepithelial origin, suggested by ultrastructural analysis, has not yet been confirmed by other methodological approaches. This mini-review summarizes the key findings of ultrastructural, immunohistochemical and molecular studies with a particular emphasis on the biological nature of the stromal component. Elucidating the lineage and molecular profile of this unique stroma may contribute to a more refined classification and enhance our understanding of salivary gland tumors.","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":" ","pages":""},"PeriodicalIF":3.1000,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"S100-positive stroma in salivary gland basal cell adenoma: recent progress and future perspectives.\",\"authors\":\"Eiichi Sasaki, Katsuhiro Masago, Yasuko Fujita\",\"doi\":\"10.1007/s00428-025-04240-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Basal cell adenoma (BCA) with S100-positive stroma exhibits tricellular differentiation, consisting of bilayered epithelial cells and S100-positive spindle-shaped stromal cells. While the neoplastic nature of the stromal component has been supported by multiple lines of evidence, its myoepithelial origin, suggested by ultrastructural analysis, has not yet been confirmed by other methodological approaches. This mini-review summarizes the key findings of ultrastructural, immunohistochemical and molecular studies with a particular emphasis on the biological nature of the stromal component. Elucidating the lineage and molecular profile of this unique stroma may contribute to a more refined classification and enhance our understanding of salivary gland tumors.\",\"PeriodicalId\":23514,\"journal\":{\"name\":\"Virchows Archiv\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-09-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Virchows Archiv\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00428-025-04240-0\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PATHOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Virchows Archiv","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00428-025-04240-0","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PATHOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

基底细胞腺瘤（BCA）具有s100阳性基质，表现为三细胞分化，由双层上皮细胞和s100阳性梭形基质细胞组成。虽然基质成分的肿瘤性质已得到多种证据的支持，但其超微结构分析提示的肌上皮起源尚未得到其他方法学方法的证实。这篇综述总结了超微结构、免疫组织化学和分子研究的主要发现，特别强调了基质成分的生物学性质。阐明这种独特基质的谱系和分子特征可能有助于更精确的分类，并增强我们对唾液腺肿瘤的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

S100-positive stroma in salivary gland basal cell adenoma: recent progress and future perspectives.

Basal cell adenoma (BCA) with S100-positive stroma exhibits tricellular differentiation, consisting of bilayered epithelial cells and S100-positive spindle-shaped stromal cells. While the neoplastic nature of the stromal component has been supported by multiple lines of evidence, its myoepithelial origin, suggested by ultrastructural analysis, has not yet been confirmed by other methodological approaches. This mini-review summarizes the key findings of ultrastructural, immunohistochemical and molecular studies with a particular emphasis on the biological nature of the stromal component. Elucidating the lineage and molecular profile of this unique stroma may contribute to a more refined classification and enhance our understanding of salivary gland tumors.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Virchows Archiv 医学-病理学

CiteScore

7.40

自引率

2.90%

发文量

204

审稿时长

4-8 weeks

期刊介绍： Manuscripts of original studies reinforcing the evidence base of modern diagnostic pathology, using immunocytochemical, molecular and ultrastructural techniques, will be welcomed. In addition, papers on critical evaluation of diagnostic criteria but also broadsheets and guidelines with a solid evidence base will be considered. Consideration will also be given to reports of work in other fields relevant to the understanding of human pathology as well as manuscripts on the application of new methods and techniques in pathology. Submission of purely experimental articles is discouraged but manuscripts on experimental work applicable to diagnostic pathology are welcomed. Biomarker studies are welcomed but need to abide by strict rules (e.g. REMARK) of adequate sample size and relevant marker choice. Single marker studies on limited patient series without validated application will as a rule not be considered. Case reports will only be considered when they provide substantial new information with an impact on understanding disease or diagnostic practice.