Amanda O. Alcantara, Bianca M. M. Reis, Juliana G. Fonseca, Maíra A. C. Sousa, Vitor Hugo A. Roxo, Guilherme J. Souza, Fúlvia de Fátima A. Castro, Guilherme N. Souza, Jorlan Fernandes, Elba Regina S. Lemos, Aline M. Souza
{"title":"巴西东南部圈养贾拉拉鼠血液学、临床生化和血细胞形态特征。","authors":"Amanda O. Alcantara, Bianca M. M. Reis, Juliana G. Fonseca, Maíra A. C. Sousa, Vitor Hugo A. Roxo, Guilherme J. Souza, Fúlvia de Fátima A. Castro, Guilherme N. Souza, Jorlan Fernandes, Elba Regina S. Lemos, Aline M. Souza","doi":"10.1111/vcp.70032","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Snakebite envenomation is a worldwide public health issue, particularly relevant to low and middle-income countries. <i>Bothrops</i> spp. antivenom is needed for snakebite treatment, which requires the maintenance of healthy snakes in captivity. Hematology and clinical biochemistry are important tools for monitoring the health status of these animals, as well as detecting hemoparasites (i.e., <i>Hepatozoon</i> spp.).</p>\n </section>\n \n <section>\n \n <h3> Objectives</h3>\n \n <p>This study aims to establish hematologic and biochemical reference intervals in a population of captive <i>B. jararaca</i> in a Brazilian serpentarium and assess blood cell morphology.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Blood samples of 32 specimens of captive <i>B. jararaca</i> were collected and analyzed for complete blood count and biochemical variables, such as total proteins, albumin, cholesterol, triglycerides, calcium, phosphorus, urea, creatinine, uric acid, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma-glutamyl transferase, and creatine kinase. Blood smears were also evaluated to investigate blood parasites. Each variable was statistically analyzed according to the ASVCP guidelines and compared between sexes and the occurrence of <i>Hepatozoon</i> spp.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>This study establishes the hematology and clinical biochemistry reference intervals and describes <i>B. jararaca</i> blood cell morphology. We observed no differences between sexes.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Our study provides the first reference intervals for hematologic and biochemical variables for <i>B. jararaca</i> on the basis of ASCVP recommendations. The RI described could be essential for the management and treatment of <i>B. jararaca</i> kept under similar captive conditions.</p>\n </section>\n </div>","PeriodicalId":23593,"journal":{"name":"Veterinary clinical pathology","volume":"54 3","pages":"221-229"},"PeriodicalIF":1.1000,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444004/pdf/","citationCount":"0","resultStr":"{\"title\":\"Hematology, Clinical Biochemistry, and Blood Cell Morphology Features of Captive Bothrops jararaca From Southeast Brazil\",\"authors\":\"Amanda O. Alcantara, Bianca M. M. Reis, Juliana G. Fonseca, Maíra A. C. Sousa, Vitor Hugo A. Roxo, Guilherme J. Souza, Fúlvia de Fátima A. Castro, Guilherme N. Souza, Jorlan Fernandes, Elba Regina S. Lemos, Aline M. Souza\",\"doi\":\"10.1111/vcp.70032\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Snakebite envenomation is a worldwide public health issue, particularly relevant to low and middle-income countries. <i>Bothrops</i> spp. antivenom is needed for snakebite treatment, which requires the maintenance of healthy snakes in captivity. Hematology and clinical biochemistry are important tools for monitoring the health status of these animals, as well as detecting hemoparasites (i.e., <i>Hepatozoon</i> spp.).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Objectives</h3>\\n \\n <p>This study aims to establish hematologic and biochemical reference intervals in a population of captive <i>B. jararaca</i> in a Brazilian serpentarium and assess blood cell morphology.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>Blood samples of 32 specimens of captive <i>B. jararaca</i> were collected and analyzed for complete blood count and biochemical variables, such as total proteins, albumin, cholesterol, triglycerides, calcium, phosphorus, urea, creatinine, uric acid, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma-glutamyl transferase, and creatine kinase. Blood smears were also evaluated to investigate blood parasites. Each variable was statistically analyzed according to the ASVCP guidelines and compared between sexes and the occurrence of <i>Hepatozoon</i> spp.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>This study establishes the hematology and clinical biochemistry reference intervals and describes <i>B. jararaca</i> blood cell morphology. We observed no differences between sexes.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>Our study provides the first reference intervals for hematologic and biochemical variables for <i>B. jararaca</i> on the basis of ASCVP recommendations. The RI described could be essential for the management and treatment of <i>B. jararaca</i> kept under similar captive conditions.</p>\\n </section>\\n </div>\",\"PeriodicalId\":23593,\"journal\":{\"name\":\"Veterinary clinical pathology\",\"volume\":\"54 3\",\"pages\":\"221-229\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2025-08-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444004/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Veterinary clinical pathology\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/vcp.70032\",\"RegionNum\":4,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Veterinary clinical pathology","FirstCategoryId":"97","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/vcp.70032","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
Hematology, Clinical Biochemistry, and Blood Cell Morphology Features of Captive Bothrops jararaca From Southeast Brazil
Background
Snakebite envenomation is a worldwide public health issue, particularly relevant to low and middle-income countries. Bothrops spp. antivenom is needed for snakebite treatment, which requires the maintenance of healthy snakes in captivity. Hematology and clinical biochemistry are important tools for monitoring the health status of these animals, as well as detecting hemoparasites (i.e., Hepatozoon spp.).
Objectives
This study aims to establish hematologic and biochemical reference intervals in a population of captive B. jararaca in a Brazilian serpentarium and assess blood cell morphology.
Methods
Blood samples of 32 specimens of captive B. jararaca were collected and analyzed for complete blood count and biochemical variables, such as total proteins, albumin, cholesterol, triglycerides, calcium, phosphorus, urea, creatinine, uric acid, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma-glutamyl transferase, and creatine kinase. Blood smears were also evaluated to investigate blood parasites. Each variable was statistically analyzed according to the ASVCP guidelines and compared between sexes and the occurrence of Hepatozoon spp.
Results
This study establishes the hematology and clinical biochemistry reference intervals and describes B. jararaca blood cell morphology. We observed no differences between sexes.
Conclusions
Our study provides the first reference intervals for hematologic and biochemical variables for B. jararaca on the basis of ASCVP recommendations. The RI described could be essential for the management and treatment of B. jararaca kept under similar captive conditions.
期刊介绍：
Veterinary Clinical Pathology is the official journal of the American Society for Veterinary Clinical Pathology (ASVCP) and the European Society of Veterinary Clinical Pathology (ESVCP). The journal''s mission is to provide an international forum for communication and discussion of scientific investigations and new developments that advance the art and science of laboratory diagnosis in animals. Veterinary Clinical Pathology welcomes original experimental research and clinical contributions involving domestic, laboratory, avian, and wildlife species in the areas of hematology, hemostasis, immunopathology, clinical chemistry, cytopathology, surgical pathology, toxicology, endocrinology, laboratory and analytical techniques, instrumentation, quality assurance, and clinical pathology education.
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