Hye Jin Hong, Na-Hyun Lee, Hye Sung Kim, Kam W Leong, Hae-Won Kim
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Biomechanics in miniature: microfluidic-based in vitro modeling to decipher mechanobiological phenomena.
Mechanobiology is a rapidly advancing field, offering innovative insights and therapeutic strategies for a range of pathophysiological conditions. Central to this progress is the ability to replicate complex cellular and tissue microenvironments in vitro. Microfluidic systems, with their precision-engineered designs, dynamic fluid control, and spatial manipulation, serve as versatile platforms for this purpose. By effectively integrating modeling and sensing capabilities, these systems further provide valuable insights into complex cellular mechanosensing events. In this review, we highlight the latest advances in microfluidic technologies, their significance in replicating living microenvironments, and the challenges they present, with a particular focus on their contributions to unraveling mechanobiological mechanisms and exploring potential therapeutic strategies.
期刊介绍：
Trends in Biotechnology publishes reviews and perspectives on the applied biological sciences, focusing on useful science applied to, derived from, or inspired by living systems.
The major themes that TIBTECH is interested in include:
Bioprocessing (biochemical engineering, applied enzymology, industrial biotechnology, biofuels, metabolic engineering)
Omics (genome editing, single-cell technologies, bioinformatics, synthetic biology)
Materials and devices (bionanotechnology, biomaterials, diagnostics/imaging/detection, soft robotics, biosensors/bioelectronics)
Therapeutics (biofabrication, stem cells, tissue engineering and regenerative medicine, antibodies and other protein drugs, drug delivery)
Agroenvironment (environmental engineering, bioremediation, genetically modified crops, sustainable development).
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