光学相干断层扫描血管造影在视网膜疾病中玻璃体视网膜界面巨噬细胞样细胞的体内检测。

IF 5.9 2区医学 Q1 OPHTHALMOLOGY

Survey of ophthalmology Pub Date : 2025-08-19 DOI:10.1016/j.survophthal.2025.08.010

Yuchen Qian, Xiren Lin, Yiran Wang, Yumei Mao, Ting Zou, Li Zhang

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引用次数: 0

摘要

视网膜疾病是一类威胁视力的疾病，其发病机制复杂，涉及多种细胞和分子因素的相互作用。炎症和免疫细胞在视网膜疾病的发生、发展和修复中起着关键作用。最近，光学相干断层扫描血管造影（OCTA）技术的进步已经能够在体内检测玻璃体视网膜界面的巨噬细胞样细胞（MLCs），并允许评估视网膜炎症，这是理解视网膜疾病病理生理学的里程碑式的进步，特别是关于MLCs的作用。我们回顾了MLCs在玻璃体视网膜界面上的作用，并讨论了OCTA技术在检测各种视网膜疾病MLCs方面的最新进展，从而展示了视网膜疾病炎症生物标志物的新进展。

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In vivo detection of macrophage-like cells at the vitreoretinal interface in retinal diseases using optical coherence tomography angiography.

Retinal diseases represent a group of vision-threatening disorders with a complex pathogenesis that involves interactions among various cellular and molecular factors. Inflammation and immune cells play a pivotal role in the initiation, progression, and repair of retinal diseases. Recently, advancements in optical coherence tomography angiography (OCTA) technology have enabled the in vivo detection of macrophage-like cells (MLCs) at the vitreoretinal interface and allowed for assessment of retinal inflammation, representing a landmark advancement for understanding the pathophysiology of retinal diseases, particularly regarding the role of MLCs. We review the role of MLCs at the vitreoretinal interface and discuss recent advances in OCTA technology for detecting MLCs across various retinal diseases, thus demonstrating new advances in inflammatory biomarkers for retinal diseases.

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来源期刊

Survey of ophthalmology 医学-眼科学

CiteScore

10.30

自引率

2.00%

发文量

138

审稿时长

14.8 weeks

期刊介绍： Survey of Ophthalmology is a clinically oriented review journal designed to keep ophthalmologists up to date. Comprehensive major review articles, written by experts and stringently refereed, integrate the literature on subjects selected for their clinical importance. Survey also includes feature articles, section reviews, book reviews, and abstracts.