Dan Shuai, Binyou Wang, Duanfang Cai, Yan Guo, Xiuping Lei, Kezhi Liu, Yilin Wang
{"title":"住院稳定期精神分裂症患者骨骼肌质量指数与认知功能的关系","authors":"Dan Shuai, Binyou Wang, Duanfang Cai, Yan Guo, Xiuping Lei, Kezhi Liu, Yilin Wang","doi":"10.30773/pi.2025.0024","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To investigate the correlation between appendicular skeletal muscle mass (ASM)/height (ASMIht), ASM/body mass index (ASMIBMI), ASM/weight (ASMIwt), and ASM/waist circumference (ASMIwc) and cognitive function among inpatients with stable schizophrenia.</p><p><strong>Methods: </strong>This was a cross-sectional study of 235 stable schizophrenia inpatients, including 60% males (n=141). Patient demographic information and body composition data were collected. The Montreal Cognitive Assessment-Chinese version (MoCA-C) was used to measure cognitive function. To determine the association between the muscle mass indices and cognitive function, multiple linear regressions were established.</p><p><strong>Results: </strong>The median age of males and females were 51 years (range 42-55) and 51 (range 39-58), respectively. Spearman's correlation analysis revealed a significant association between ASMIwc and the MoCA-C scores (r=0.323, false discovery rate [FDR]=0.004) in males, while ASMIBMI, ASMIwt, and ASMIwc (r=0.268-0.421, all FDR <0.05) were significantly correlated with MoCA-C scores in females. Furthermore, covariate-adjusted multiple linear regression analysis further confirmed that only the ASMIwc was related to MoCAC scores after controlling for relevant variables (males: β=0.565, 95% confidence interval [CI], 0.156-0.974, p=0.007; females: β=0.96, 95% CI, 0.394-1.526, p=0.001).</p><p><strong>Conclusion: </strong>Our findings showed a substantial correlation between the ASMIwc and cognitive function in schizophrenia inpatients. Further validation of these data in broader study populations is now necessary.</p>","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":" ","pages":"1048-1056"},"PeriodicalIF":1.8000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444197/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association Between Skeletal Muscle Mass Indices and Cognitive Function Among Inpatients With Stable Schizophrenia.\",\"authors\":\"Dan Shuai, Binyou Wang, Duanfang Cai, Yan Guo, Xiuping Lei, Kezhi Liu, Yilin Wang\",\"doi\":\"10.30773/pi.2025.0024\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To investigate the correlation between appendicular skeletal muscle mass (ASM)/height (ASMIht), ASM/body mass index (ASMIBMI), ASM/weight (ASMIwt), and ASM/waist circumference (ASMIwc) and cognitive function among inpatients with stable schizophrenia.</p><p><strong>Methods: </strong>This was a cross-sectional study of 235 stable schizophrenia inpatients, including 60% males (n=141). Patient demographic information and body composition data were collected. The Montreal Cognitive Assessment-Chinese version (MoCA-C) was used to measure cognitive function. To determine the association between the muscle mass indices and cognitive function, multiple linear regressions were established.</p><p><strong>Results: </strong>The median age of males and females were 51 years (range 42-55) and 51 (range 39-58), respectively. Spearman's correlation analysis revealed a significant association between ASMIwc and the MoCA-C scores (r=0.323, false discovery rate [FDR]=0.004) in males, while ASMIBMI, ASMIwt, and ASMIwc (r=0.268-0.421, all FDR <0.05) were significantly correlated with MoCA-C scores in females. Furthermore, covariate-adjusted multiple linear regression analysis further confirmed that only the ASMIwc was related to MoCAC scores after controlling for relevant variables (males: β=0.565, 95% confidence interval [CI], 0.156-0.974, p=0.007; females: β=0.96, 95% CI, 0.394-1.526, p=0.001).</p><p><strong>Conclusion: </strong>Our findings showed a substantial correlation between the ASMIwc and cognitive function in schizophrenia inpatients. Further validation of these data in broader study populations is now necessary.</p>\",\"PeriodicalId\":21164,\"journal\":{\"name\":\"Psychiatry Investigation\",\"volume\":\" \",\"pages\":\"1048-1056\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444197/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Psychiatry Investigation\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.30773/pi.2025.0024\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/8/21 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psychiatry Investigation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.30773/pi.2025.0024","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/21 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"PSYCHIATRY","Score":null,"Total":0}
Association Between Skeletal Muscle Mass Indices and Cognitive Function Among Inpatients With Stable Schizophrenia.
Objective: To investigate the correlation between appendicular skeletal muscle mass (ASM)/height (ASMIht), ASM/body mass index (ASMIBMI), ASM/weight (ASMIwt), and ASM/waist circumference (ASMIwc) and cognitive function among inpatients with stable schizophrenia.
Methods: This was a cross-sectional study of 235 stable schizophrenia inpatients, including 60% males (n=141). Patient demographic information and body composition data were collected. The Montreal Cognitive Assessment-Chinese version (MoCA-C) was used to measure cognitive function. To determine the association between the muscle mass indices and cognitive function, multiple linear regressions were established.
Results: The median age of males and females were 51 years (range 42-55) and 51 (range 39-58), respectively. Spearman's correlation analysis revealed a significant association between ASMIwc and the MoCA-C scores (r=0.323, false discovery rate [FDR]=0.004) in males, while ASMIBMI, ASMIwt, and ASMIwc (r=0.268-0.421, all FDR <0.05) were significantly correlated with MoCA-C scores in females. Furthermore, covariate-adjusted multiple linear regression analysis further confirmed that only the ASMIwc was related to MoCAC scores after controlling for relevant variables (males: β=0.565, 95% confidence interval [CI], 0.156-0.974, p=0.007; females: β=0.96, 95% CI, 0.394-1.526, p=0.001).
Conclusion: Our findings showed a substantial correlation between the ASMIwc and cognitive function in schizophrenia inpatients. Further validation of these data in broader study populations is now necessary.
期刊介绍：
The Psychiatry Investigation is published on the 25th day of every month in English by the Korean Neuropsychiatric Association (KNPA). The Journal covers the whole range of psychiatry and neuroscience. Both basic and clinical contributions are encouraged from all disciplines and research areas relevant to the pathophysiology and management of neuropsychiatric disorders and symptoms, as well as researches related to cross cultural psychiatry and ethnic issues in psychiatry. The Journal publishes editorials, review articles, original articles, brief reports, viewpoints and correspondences. All research articles are peer reviewed. Contributions are accepted for publication on the condition that their substance has not been published or submitted for publication elsewhere. Authors submitting papers to the Journal (serially or otherwise) with a common theme or using data derived from the same sample (or a subset thereof) must send details of all relevant previous publications and simultaneous submissions. The Journal is not responsible for statements made by contributors. Material in the Journal does not necessarily reflect the views of the Editor or of the KNPA. Manuscripts accepted for publication are copy-edited to improve readability and to ensure conformity with house style.
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