Yiting You, Jingqian Huang, Xiaoyan Zhu, Hui Sheng, Yujian Liu
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引用次数: 0
摘要
目的：本文旨在探讨细胞色素P450亚家族1 （CYP1）酶在急性肺损伤（ALI）中的作用和机制，并探讨其作为治疗靶点的潜力。方法：通过PubMed和Web of Science进行全面的文献检索，找出CYP1酶（特别是CYP1A和cyp1b1）参与各种形式ALI的相关研究，包括高氧性肺损伤、败血症相关性ALI和COVID-19肺炎。结果：由芳烃受体（AhR）诱导的CYP1酶对ALI有不同程度的影响。CYP1A酶具有保护作用，而CYP1B1可能通过氧化应激相关途径如Nrf2、NF-κB和MAPK信号通路促进肺损伤。结论：CYP1亚型在急性呼吸系统疾病中的独特功能提示其临床相关性，突出了亚型特异性靶向治疗急性呼吸系统疾病的潜力。
Cytochrome P450 (CYP) 1 enzymes in acute lung injury: from molecular insights to therapeutic implications.
Objective: This review aims to explore the roles and mechanisms of cytochrome P450 subfamily 1 (CYP1) enzymes in acute lung injury (ALI), and to discuss their potential as therapeutic targets.
Methods: A comprehensive literature search was conducted using PubMed and Web of Science to identify relevant studies on the involvement of CYP1 enzymes-specifically CYP1A and CYP1B1-in various forms of ALI, including hyperoxic lung injury, sepsis-associated ALI, and COVID-19 pneumonia.
Results: CYP1 enzymes, induced by the aromatic hydrocarbon receptor (AhR), contribute differentially to ALI. CYP1A enzymes exhibit protective effects, whereas CYP1B1 promotes lung injury, potentially through oxidative stress-related pathways such as Nrf2, NF-κB, and MAPK signaling.
Conclusion: The distinct functions of CYP1 isoforms in ALI suggest their clinical relevance, highlighting the potential for isoform-specific targeting in the treatment of acute respiratory conditions.
期刊介绍：
Redox Report is a multidisciplinary peer-reviewed open access journal focusing on the role of free radicals, oxidative stress, activated oxygen, perioxidative and redox processes, primarily in the human environment and human pathology. Relevant papers on the animal and plant environment, biology and pathology will also be included.
While emphasis is placed upon methodological and intellectual advances underpinned by new data, the journal offers scope for review, hypotheses, critiques and other forms of discussion.
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