使用延迟期动态对比增强心脏MRI改进心肌组织表征。

IF 4.2 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Li-Ting Huang, Xinheng Zhang, Xinqi Li, Archana Malagi, Yuheng Huang, Xingmin Guan, Hao Ho, Alan Kwan, Janet Wei, Xiaoming Bi, Anthony G Christodoulou, Debiao Li, Hui Han, Yen-Wen Liu, Rohan Dharmakumar, Hsin-Jung Yang
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The dDCE parameters derived from the 30-minute contrast material washout process (dDCE<sub>30min</sub>) and a 5-minute image subset (dDCE<sub>5min</sub>) were compared. LGE images were synthesized from the dDCE<sub>5min</sub> maps (LGE<sub>dDCE</sub>) and compared LGE extent and transmurality with the standard LGE images acquired at 15 minutes after contrast material injection (LGE<sub>standard</sub>). Statistical analyses used paired tests for dependent group comparisons. Results The dDCE<sub>30min</sub> map demonstrated that extravascular extracellular volume and capillary permeability surface area product were higher in MI regions than in remote myocardium (61.12% ± 13.65 [SD] vs 13.43% ± 5.00; <i>P</i> = .02; 5.08 mL × g-1 × min-1 ± 4.10 vs 0.42 mL × g-1 × min-1 ± 0.55; <i>P</i> = .02, respectively). There was no evidence of differences between dDCE<sub>5min</sub> parameters and dDCE<sub>30min</sub> parameters (all <i>P</i> > .05). 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引用次数: 0

摘要

目的评价延迟期动态对比增强(dDCE) MRI模型在再灌注心肌梗死(MI)注射造影剂后5分钟内心肌组织生理和晚期钆增强(LGE)定量评估中的作用。材料和方法本动物研究包括11只再灌注心肌梗死犬(7只雌性)。采用动态对比后T1图的dDCE模型来描述无偏对比材料冲洗过程。比较30分钟造影剂冲洗过程(dDCE30min)和5分钟图像子集(dDCE5min)所得的dDCE参数。从dDCE5min图(LGEdDCE)合成LGE图像,并将LGE范围和透性与注射造影剂后15分钟获得的标准LGE图像(LGEstandard)进行比较。统计分析使用配对检验进行依赖组比较。结果dDCE30min图显示心肌梗死区血管外细胞外体积和毛细血管通透性表面积积高于远端心肌区(61.12%±13.65 [SD] vs 13.43%±5.00,P = 0.02; 5.08 mL × g-1 × min-1±4.10 vs 0.42 mL × g-1 × min-1±0.55,P = 0.02)。dDCE5min参数与dDCE30min参数间无差异(P均为0.05)。LGEdDCE与LGEstandard在LGE区域(30.65%±11.94 vs 30.66%±11.94,P = 0.99)和跨壁性(54.87%±15.57 vs 53.27%±15.98,P = 0.06)也无差异,但LGEdDCE的比噪比更高(14.62±13.03 vs 1.41±0.97,P < 0.01)。LGEdDCE检测心肌梗死的受试者工作特征曲线下面积为0.97 (95% CI: 0.94, >0.99),敏感性94.4%,特异性96.7%。结论建立的dDCE MRI心肌组织评估模型可增强病变对比,量化临床相关生理参数,支持心脏病心肌损伤的综合评价。关键词:动态增强MRI,心肌梗死,MRI,药代动力学,缺血性心脏病©rsna, 2025。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Improved Myocardial Tissue Characterization Using Delayed-Phase Dynamic Contrast-enhanced Cardiac MRI.

Purpose To evaluate the performance of a delayed-phase dynamic contrast-enhanced (dDCE) MRI model in quantitative assessment of myocardial tissue physiology and late gadolinium enhancement (LGE) within 5 minutes after contrast material injection in reperfused myocardial infarction (MI). Materials and Methods This animal study included 11 canines (seven female) with reperfused MI. A dDCE model using dynamic postcontrast T1 maps was adopted to depict an unbiased contrast material washout process. The dDCE parameters derived from the 30-minute contrast material washout process (dDCE30min) and a 5-minute image subset (dDCE5min) were compared. LGE images were synthesized from the dDCE5min maps (LGEdDCE) and compared LGE extent and transmurality with the standard LGE images acquired at 15 minutes after contrast material injection (LGEstandard). Statistical analyses used paired tests for dependent group comparisons. Results The dDCE30min map demonstrated that extravascular extracellular volume and capillary permeability surface area product were higher in MI regions than in remote myocardium (61.12% ± 13.65 [SD] vs 13.43% ± 5.00; P = .02; 5.08 mL × g-1 × min-1 ± 4.10 vs 0.42 mL × g-1 × min-1 ± 0.55; P = .02, respectively). There was no evidence of differences between dDCE5min parameters and dDCE30min parameters (all P > .05). There was also no evidence of a difference between LGEdDCE and LGEstandard in LGE area (30.65% ± 11.94 vs 30.66% ± 11.94; P = .99) or transmurality (54.87% ± 15.57 vs 53.27% ± 15.98; P = .06), but LGEdDCE demonstrated a higher contrast-to-noise ratio (14.62 ± 13.03 vs 1.41 ± 0.97; P < .01). The area under the receiver operating characteristic curve of MI detection using LGEdDCE was 0.97 (95% CI: 0.94, >0.99), with 94.4% sensitivity and 96.7% specificity. Conclusion The developed dDCE MRI model for myocardial tissue assessment shows potential to enhance lesion contrast, quantify clinically relevant physiologic parameters, and support comprehensive evaluation of myocardial injury in heart disease. Keywords: Dynamic Contrast-enhanced MRI, Myocardial Infarction, MRI, Pharmacokinetics, Ischemic Heart Disease Supplemental material is available for this article. © RSNA, 2025.

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