Rina S Fox, Terry A Badger, Samantha Moya, Lisa M Gudenkauf, Marjorie A Nelson, Riley M O'Neill, Jacqueline J Leete, Sydney E Friedman, Emmanuel Katsanis, David E Victorson, Stacy D Sanford, Frank J Penedo, Michael H Antoni, Laura B Oswald
{"title":"青少年和青年癌症幸存者电子健康干预的HRQOL概念验证分析：一份简短报告。","authors":"Rina S Fox, Terry A Badger, Samantha Moya, Lisa M Gudenkauf, Marjorie A Nelson, Riley M O'Neill, Jacqueline J Leete, Sydney E Friedman, Emmanuel Katsanis, David E Victorson, Stacy D Sanford, Frank J Penedo, Michael H Antoni, Laura B Oswald","doi":"10.1002/pon.70234","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Adolescent and young adult (AYA) cancer survivors ages 18-39 report elevated stress and poor health-related quality of life (HRQOL), yet few evidence-based stress management interventions exist that meet their specific needs. Our team designed TOGETHER, a 10-week eHealth group-delivered behavioral intervention designed to improve HRQOL via stress management skills training. To date, TOGETHER has been delivered to seven groups of AYAs, and its feasibility and acceptability have been well established.</p><p><strong>Aims: </strong>This proof-of-concept analysis explored TOGETHER's impact on patient-reported outcomes among AYAs.</p><p><strong>Methods: </strong>Participants were English-speaking AYAs aged 18-39 who were diagnosed with cancer while aged 15-39 and had completed curative treatment within the past five years. Patient-reported outcomes were assessed at baseline and post-intervention and included HRQOL, stress management skills self-efficacy, coping strategies, and depression and anxiety symptoms. Pre-to-post-intervention changes were assessed with paired-samples t-tests among those with complete data (n = 39) and using a series of imputation strategies. The proportion of participants achieving clinically meaningful change was computed when possible.</p><p><strong>Results: </strong>Participants (N = 51) had an average age of 29 years and were predominantly female (78%), White (69%), and non-Hispanic (80%). HRQOL significantly improved from pre-to post-intervention with small-to-moderate effect sizes (gs ranged from 0.32-0.60), and more than half of participants (51%-59%) demonstrated clinically meaningful improvement. Statistically significant improvements were found for stress management skills self-efficacy, coping, and depression symptoms, but not anxiety symptoms.</p><p><strong>Conclusions: </strong>Results provide proof-of-concept evidence that TOGETHER can meaningfully improve patient-reported outcomes among AYA survivors, supporting continued evaluation of the intervention.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov; NCT05048316, NCT05054569, NCT05597228, NCT05952492.</p>","PeriodicalId":20779,"journal":{"name":"Psycho‐Oncology","volume":"34 7","pages":"e70234"},"PeriodicalIF":3.5000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"An HRQOL Proof-Of-Concept Analysis of the eHealth TOGETHER Intervention for Adolescent and Young Adult Cancer Survivors: A Brief Report.\",\"authors\":\"Rina S Fox, Terry A Badger, Samantha Moya, Lisa M Gudenkauf, Marjorie A Nelson, Riley M O'Neill, Jacqueline J Leete, Sydney E Friedman, Emmanuel Katsanis, David E Victorson, Stacy D Sanford, Frank J Penedo, Michael H Antoni, Laura B Oswald\",\"doi\":\"10.1002/pon.70234\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Adolescent and young adult (AYA) cancer survivors ages 18-39 report elevated stress and poor health-related quality of life (HRQOL), yet few evidence-based stress management interventions exist that meet their specific needs. Our team designed TOGETHER, a 10-week eHealth group-delivered behavioral intervention designed to improve HRQOL via stress management skills training. To date, TOGETHER has been delivered to seven groups of AYAs, and its feasibility and acceptability have been well established.</p><p><strong>Aims: </strong>This proof-of-concept analysis explored TOGETHER's impact on patient-reported outcomes among AYAs.</p><p><strong>Methods: </strong>Participants were English-speaking AYAs aged 18-39 who were diagnosed with cancer while aged 15-39 and had completed curative treatment within the past five years. Patient-reported outcomes were assessed at baseline and post-intervention and included HRQOL, stress management skills self-efficacy, coping strategies, and depression and anxiety symptoms. Pre-to-post-intervention changes were assessed with paired-samples t-tests among those with complete data (n = 39) and using a series of imputation strategies. The proportion of participants achieving clinically meaningful change was computed when possible.</p><p><strong>Results: </strong>Participants (N = 51) had an average age of 29 years and were predominantly female (78%), White (69%), and non-Hispanic (80%). HRQOL significantly improved from pre-to post-intervention with small-to-moderate effect sizes (gs ranged from 0.32-0.60), and more than half of participants (51%-59%) demonstrated clinically meaningful improvement. Statistically significant improvements were found for stress management skills self-efficacy, coping, and depression symptoms, but not anxiety symptoms.</p><p><strong>Conclusions: </strong>Results provide proof-of-concept evidence that TOGETHER can meaningfully improve patient-reported outcomes among AYA survivors, supporting continued evaluation of the intervention.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov; NCT05048316, NCT05054569, NCT05597228, NCT05952492.</p>\",\"PeriodicalId\":20779,\"journal\":{\"name\":\"Psycho‐Oncology\",\"volume\":\"34 7\",\"pages\":\"e70234\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Psycho‐Oncology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/pon.70234\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psycho‐Oncology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/pon.70234","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
An HRQOL Proof-Of-Concept Analysis of the eHealth TOGETHER Intervention for Adolescent and Young Adult Cancer Survivors: A Brief Report.
Background: Adolescent and young adult (AYA) cancer survivors ages 18-39 report elevated stress and poor health-related quality of life (HRQOL), yet few evidence-based stress management interventions exist that meet their specific needs. Our team designed TOGETHER, a 10-week eHealth group-delivered behavioral intervention designed to improve HRQOL via stress management skills training. To date, TOGETHER has been delivered to seven groups of AYAs, and its feasibility and acceptability have been well established.
Aims: This proof-of-concept analysis explored TOGETHER's impact on patient-reported outcomes among AYAs.
Methods: Participants were English-speaking AYAs aged 18-39 who were diagnosed with cancer while aged 15-39 and had completed curative treatment within the past five years. Patient-reported outcomes were assessed at baseline and post-intervention and included HRQOL, stress management skills self-efficacy, coping strategies, and depression and anxiety symptoms. Pre-to-post-intervention changes were assessed with paired-samples t-tests among those with complete data (n = 39) and using a series of imputation strategies. The proportion of participants achieving clinically meaningful change was computed when possible.
Results: Participants (N = 51) had an average age of 29 years and were predominantly female (78%), White (69%), and non-Hispanic (80%). HRQOL significantly improved from pre-to post-intervention with small-to-moderate effect sizes (gs ranged from 0.32-0.60), and more than half of participants (51%-59%) demonstrated clinically meaningful improvement. Statistically significant improvements were found for stress management skills self-efficacy, coping, and depression symptoms, but not anxiety symptoms.
Conclusions: Results provide proof-of-concept evidence that TOGETHER can meaningfully improve patient-reported outcomes among AYA survivors, supporting continued evaluation of the intervention.
期刊介绍：
Psycho-Oncology is concerned with the psychological, social, behavioral, and ethical aspects of cancer. This subspeciality addresses the two major psychological dimensions of cancer: the psychological responses of patients to cancer at all stages of the disease, and that of their families and caretakers; and the psychological, behavioral and social factors that may influence the disease process. Psycho-oncology is an area of multi-disciplinary interest and has boundaries with the major specialities in oncology: the clinical disciplines (surgery, medicine, pediatrics, radiotherapy), epidemiology, immunology, endocrinology, biology, pathology, bioethics, palliative care, rehabilitation medicine, clinical trials research and decision making, as well as psychiatry and psychology.
This international journal is published twelve times a year and will consider contributions to research of clinical and theoretical interest. Topics covered are wide-ranging and relate to the psychosocial aspects of cancer and AIDS-related tumors, including: epidemiology, quality of life, palliative and supportive care, psychiatry, psychology, sociology, social work, nursing and educational issues.
Special reviews are offered from time to time. There is a section reviewing recently published books. A society news section is available for the dissemination of information relating to meetings, conferences and other society-related topics. Summary proceedings of important national and international symposia falling within the aims of the journal are presented.
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