Ying Fan, Lei Wu, Yalan Zhang, Qin Hu, Jing Mei, Kousalya Prabahar, Benjamin Hernández-Wolters, Hamed Kord-Varkaneh, Changjiang Lei, Su Zheng
{"title":"补充秋葵对2型糖尿病患者糖尿病和肥胖生物标志物的影响：随机对照试验的系统评价和荟萃分析","authors":"Ying Fan, Lei Wu, Yalan Zhang, Qin Hu, Jing Mei, Kousalya Prabahar, Benjamin Hernández-Wolters, Hamed Kord-Varkaneh, Changjiang Lei, Su Zheng","doi":"10.1002/ptr.70071","DOIUrl":null,"url":null,"abstract":"<p><p>Conflicting results have been reported regarding the effects of okra on diabetes biomarkers in patients with type 2 diabetes. These inconsistencies may stem from factors such as dosage, intervention duration, and study design. To address these discrepancies, this systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to evaluate the effects of okra (Abelmoschus esculentus) supplementation on diabetes and obesity markers in patients with type 2 diabetes. Relevant studies published up to July 15, 2024, were identified through comprehensive searches in databases including Scopus, Web of Science, PubMed/Medline, and Embase. Studies were included if they assessed the effects of okra supplementation on diabetes and obesity biomarkers in patients with type 2 diabetes. A random-effects model was employed to calculate effect sizes, reported as weighted mean differences (WMD) with 95% confidence intervals (CI). A total of six eligible RCTs was included in the final analysis. The meta-analysis revealed that okra supplementation significantly reduced fasting blood glucose (FBG) (WMD: -21.72 mg/dL, 95% CI: -36.86 to -6.58, p = 0.005) and glycated hemoglobin (HbA1c) levels (WMD: -0.42%, 95% CI: -0.64 to -0.19, p < 0.001). However, no significant effects were observed on insulin levels (WMD: 0.54 μU/mL, 95% CI: -1.03 to 2.12, p = 0.498), insulin resistance as assessed by HOMA-IR (WMD: -0.31, 95% CI: -1.37 to 0.75, p = 0.566), body mass index (BMI) (WMD: -0.24 kg/m<sup>2</sup>, 95% CI: -0.62 to 0.14, p = 0.220), or body weight (WMD: -0.83 kg, 95% CI: -2.55 to 0.87, p = 0.338). This systematic review and meta-analysis is the first to confirm the positive effects of okra supplementation on glycemic control in patients with type 2 diabetes, specifically by reducing FBG and HbA1c levels.</p>","PeriodicalId":20110,"journal":{"name":"Phytotherapy Research","volume":" ","pages":""},"PeriodicalIF":6.3000,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Impact of Okra (Abelmoschus esculentus) Supplementation on Diabetes and Obesity Biomarkers in Type 2 Diabetes Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.\",\"authors\":\"Ying Fan, Lei Wu, Yalan Zhang, Qin Hu, Jing Mei, Kousalya Prabahar, Benjamin Hernández-Wolters, Hamed Kord-Varkaneh, Changjiang Lei, Su Zheng\",\"doi\":\"10.1002/ptr.70071\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Conflicting results have been reported regarding the effects of okra on diabetes biomarkers in patients with type 2 diabetes. These inconsistencies may stem from factors such as dosage, intervention duration, and study design. To address these discrepancies, this systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to evaluate the effects of okra (Abelmoschus esculentus) supplementation on diabetes and obesity markers in patients with type 2 diabetes. Relevant studies published up to July 15, 2024, were identified through comprehensive searches in databases including Scopus, Web of Science, PubMed/Medline, and Embase. Studies were included if they assessed the effects of okra supplementation on diabetes and obesity biomarkers in patients with type 2 diabetes. A random-effects model was employed to calculate effect sizes, reported as weighted mean differences (WMD) with 95% confidence intervals (CI). A total of six eligible RCTs was included in the final analysis. The meta-analysis revealed that okra supplementation significantly reduced fasting blood glucose (FBG) (WMD: -21.72 mg/dL, 95% CI: -36.86 to -6.58, p = 0.005) and glycated hemoglobin (HbA1c) levels (WMD: -0.42%, 95% CI: -0.64 to -0.19, p < 0.001). However, no significant effects were observed on insulin levels (WMD: 0.54 μU/mL, 95% CI: -1.03 to 2.12, p = 0.498), insulin resistance as assessed by HOMA-IR (WMD: -0.31, 95% CI: -1.37 to 0.75, p = 0.566), body mass index (BMI) (WMD: -0.24 kg/m<sup>2</sup>, 95% CI: -0.62 to 0.14, p = 0.220), or body weight (WMD: -0.83 kg, 95% CI: -2.55 to 0.87, p = 0.338). 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The Impact of Okra (Abelmoschus esculentus) Supplementation on Diabetes and Obesity Biomarkers in Type 2 Diabetes Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Conflicting results have been reported regarding the effects of okra on diabetes biomarkers in patients with type 2 diabetes. These inconsistencies may stem from factors such as dosage, intervention duration, and study design. To address these discrepancies, this systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to evaluate the effects of okra (Abelmoschus esculentus) supplementation on diabetes and obesity markers in patients with type 2 diabetes. Relevant studies published up to July 15, 2024, were identified through comprehensive searches in databases including Scopus, Web of Science, PubMed/Medline, and Embase. Studies were included if they assessed the effects of okra supplementation on diabetes and obesity biomarkers in patients with type 2 diabetes. A random-effects model was employed to calculate effect sizes, reported as weighted mean differences (WMD) with 95% confidence intervals (CI). A total of six eligible RCTs was included in the final analysis. The meta-analysis revealed that okra supplementation significantly reduced fasting blood glucose (FBG) (WMD: -21.72 mg/dL, 95% CI: -36.86 to -6.58, p = 0.005) and glycated hemoglobin (HbA1c) levels (WMD: -0.42%, 95% CI: -0.64 to -0.19, p < 0.001). However, no significant effects were observed on insulin levels (WMD: 0.54 μU/mL, 95% CI: -1.03 to 2.12, p = 0.498), insulin resistance as assessed by HOMA-IR (WMD: -0.31, 95% CI: -1.37 to 0.75, p = 0.566), body mass index (BMI) (WMD: -0.24 kg/m2, 95% CI: -0.62 to 0.14, p = 0.220), or body weight (WMD: -0.83 kg, 95% CI: -2.55 to 0.87, p = 0.338). This systematic review and meta-analysis is the first to confirm the positive effects of okra supplementation on glycemic control in patients with type 2 diabetes, specifically by reducing FBG and HbA1c levels.
期刊介绍：
Phytotherapy Research is an internationally recognized pharmacological journal that serves as a trailblazing resource for biochemists, pharmacologists, and toxicologists. We strive to disseminate groundbreaking research on medicinal plants, pushing the boundaries of knowledge and understanding in this field.
Our primary focus areas encompass pharmacology, toxicology, and the clinical applications of herbs and natural products in medicine. We actively encourage submissions on the effects of commonly consumed food ingredients and standardized plant extracts. We welcome a range of contributions including original research papers, review articles, and letters.
By providing a platform for the latest developments and discoveries in phytotherapy, we aim to support the advancement of scientific knowledge and contribute to the improvement of modern medicine.
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