Priyanka Kataria, Naga Jyothi Pullagurla, Debabrata Laha, Patrick D'Silva
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Control of heat and oxidative stress adaptation by the DJ-1 paralogs in Arabidopsis thaliana.
Plant growth and development are highly regulated processes and are majorly controlled by various environmental factors, whose extreme exposures lead to chronic stress conditions promoting reactive oxygen species (ROS) and carbonyl species (RCS) production. ROS and RCS extensively damage cellular biomolecules and organelles, affecting a plant's development. Emerging reports highlight that the multi-stress responding DJ-1 superfamily proteins are critical in attenuating cytotoxic effects associated with abiotic stress. The current report, validated in yeast and plant models, shows that AtDJ-1C and AtDJ-1E are robust antioxidants that scavenge ROS and improve survival under oxidative stress. Although they lack conventional glyoxalases and do not attenuate the glycation of proteins, AtDJ-1C and AtDJ-1E preserve the GSH pool and regulate redox homeostasis. Moreover, gene expression profiling indicates that levels of AtDJ-1C and AtDJ-1E are rapidly established to counter heat and oxidative stress conditions. Notably, the knockdown of AtDJ-1 C and AtDJ-1E promotes detrimental alterations such as reduced chlorophyll retention, impaired root morphogenesis, and induced sensitivity to heat stress due to ROS elevation. Contrastingly, overexpression of AtDJ-1C and AtDJ-1E improved plant height and rosette formation under physiological conditions. In conclusion, our study unravels the pivotal functions of Arabidopsis thaliana DJ-1C and DJ-1E in governing plant health and survival under heat and oxidative stress conditions.
期刊介绍:
Plant Molecular Biology is an international journal dedicated to rapid publication of original research articles in all areas of plant biology.The Editorial Board welcomes full-length manuscripts that address important biological problems of broad interest, including research in comparative genomics, functional genomics, proteomics, bioinformatics, computational biology, biochemical and regulatory networks, and biotechnology. Because space in the journal is limited, however, preference is given to publication of results that provide significant new insights into biological problems and that advance the understanding of structure, function, mechanisms, or regulation. Authors must ensure that results are of high quality and that manuscripts are written for a broad plant science audience.