全球儿童肺动脉高压负担,1990-2021:来自2021年全球疾病负担研究的系统分析

IF 1.4 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Taixiang Liu, Xiaoliang Liu, Chenhong Wang, Jinxin Zheng, Liping Shi, Zheng Chen
{"title":"全球儿童肺动脉高压负担,1990-2021:来自2021年全球疾病负担研究的系统分析","authors":"Taixiang Liu, Xiaoliang Liu, Chenhong Wang, Jinxin Zheng, Liping Shi, Zheng Chen","doi":"10.1007/s00246-025-04009-x","DOIUrl":null,"url":null,"abstract":"<p><p>Pediatric pulmonary arterial hypertension (PAH) remains a critical global health threat characterized by disparities in burden driven by sociodemographic factors, with persistent gaps in early screening and equitable healthcare access despite therapeutic advances. Leveraging Global Burden of Disease 2021 data including 204 countries and territories from 1990 to 2021, this study analyzed trends in incidence, prevalence, mortality, and disability-adjusted life years (DALYs) using joinpoint regression to discern temporal patterns, inequality metrics to quantify disparities, and decomposition and frontier analyses to investigate DALY change drivers and health system inefficiencies. Globally, pediatric PAH incidence increased by 20.1% from 1990 to 2021, while deaths and DALYs decreased significantly by 57.7 and 57.9%, respectively. Low-middle socio-demographic index (SDI) regions reported the highest incidence and deaths, whereas high-SDI regions achieved the most substantial mortality reductions. Neonates faced the highest mortality risk (4.86 per 100,000 population). Females demonstrated higher incidence and prevalence, while males under 10 years had elevated mortality and DALYs-a trend reversing in adolescence. Low-SDI regions experienced increasing burdens due to demographic shifts, and frontier analysis revealed inefficiencies even in resource-rich high-SDI countries. Addressing persistent inequities necessitates tailored regional strategies: optimizing resource allocation in high-SDI settings and expanding low-cost screening and treatment in low-SDI regions, alongside prioritizing neonatal care and risk mitigation to achieve global health equity in pediatric PAH.</p>","PeriodicalId":19814,"journal":{"name":"Pediatric Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4000,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Global Burden of Pediatric Pulmonary Arterial Hypertension, 1990-2021: A Systematic Analysis from the Global Burden of Disease Study 2021.\",\"authors\":\"Taixiang Liu, Xiaoliang Liu, Chenhong Wang, Jinxin Zheng, Liping Shi, Zheng Chen\",\"doi\":\"10.1007/s00246-025-04009-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Pediatric pulmonary arterial hypertension (PAH) remains a critical global health threat characterized by disparities in burden driven by sociodemographic factors, with persistent gaps in early screening and equitable healthcare access despite therapeutic advances. Leveraging Global Burden of Disease 2021 data including 204 countries and territories from 1990 to 2021, this study analyzed trends in incidence, prevalence, mortality, and disability-adjusted life years (DALYs) using joinpoint regression to discern temporal patterns, inequality metrics to quantify disparities, and decomposition and frontier analyses to investigate DALY change drivers and health system inefficiencies. Globally, pediatric PAH incidence increased by 20.1% from 1990 to 2021, while deaths and DALYs decreased significantly by 57.7 and 57.9%, respectively. Low-middle socio-demographic index (SDI) regions reported the highest incidence and deaths, whereas high-SDI regions achieved the most substantial mortality reductions. Neonates faced the highest mortality risk (4.86 per 100,000 population). Females demonstrated higher incidence and prevalence, while males under 10 years had elevated mortality and DALYs-a trend reversing in adolescence. Low-SDI regions experienced increasing burdens due to demographic shifts, and frontier analysis revealed inefficiencies even in resource-rich high-SDI countries. Addressing persistent inequities necessitates tailored regional strategies: optimizing resource allocation in high-SDI settings and expanding low-cost screening and treatment in low-SDI regions, alongside prioritizing neonatal care and risk mitigation to achieve global health equity in pediatric PAH.</p>\",\"PeriodicalId\":19814,\"journal\":{\"name\":\"Pediatric Cardiology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2025-08-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pediatric Cardiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00246-025-04009-x\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric Cardiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00246-025-04009-x","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0

摘要

儿童肺动脉高压(PAH)仍然是一个严重的全球健康威胁,其特征是由社会人口因素驱动的负担差异,尽管治疗取得进展,但在早期筛查和公平医疗保健获取方面仍然存在差距。利用全球疾病负担2021数据,包括204个国家和地区从1990年到2021年,本研究分析了发病率、患病率、死亡率和残疾调整生命年(DALYs)的趋势,使用联点回归来识别时间模式,不平等指标来量化差异,以及分解和前沿分析来调查DALY变化驱动因素和卫生系统效率低下。在全球范围内,从1990年到2021年,儿童多环芳烃发病率增加了20.1%,而死亡率和DALYs分别显著下降了57.7%和57.9%。中低社会人口指数区域报告的发病率和死亡率最高,而高社会人口指数区域的死亡率下降幅度最大。新生儿面临最高的死亡风险(每10万人4.86人)。女性的发病率和流行率较高,而10岁以下男性的死亡率和残疾人数较高,这一趋势在青春期发生逆转。由于人口结构的变化,低sdi地区的负担越来越重,前沿分析显示,即使在资源丰富的高sdi国家,效率也很低。解决持续存在的不平等问题需要有针对性的区域战略:在高sdi环境中优化资源分配,在低sdi地区扩大低成本筛查和治疗,同时优先考虑新生儿护理和降低风险,以实现儿科多环性肺动脉高压的全球卫生公平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Global Burden of Pediatric Pulmonary Arterial Hypertension, 1990-2021: A Systematic Analysis from the Global Burden of Disease Study 2021.

Pediatric pulmonary arterial hypertension (PAH) remains a critical global health threat characterized by disparities in burden driven by sociodemographic factors, with persistent gaps in early screening and equitable healthcare access despite therapeutic advances. Leveraging Global Burden of Disease 2021 data including 204 countries and territories from 1990 to 2021, this study analyzed trends in incidence, prevalence, mortality, and disability-adjusted life years (DALYs) using joinpoint regression to discern temporal patterns, inequality metrics to quantify disparities, and decomposition and frontier analyses to investigate DALY change drivers and health system inefficiencies. Globally, pediatric PAH incidence increased by 20.1% from 1990 to 2021, while deaths and DALYs decreased significantly by 57.7 and 57.9%, respectively. Low-middle socio-demographic index (SDI) regions reported the highest incidence and deaths, whereas high-SDI regions achieved the most substantial mortality reductions. Neonates faced the highest mortality risk (4.86 per 100,000 population). Females demonstrated higher incidence and prevalence, while males under 10 years had elevated mortality and DALYs-a trend reversing in adolescence. Low-SDI regions experienced increasing burdens due to demographic shifts, and frontier analysis revealed inefficiencies even in resource-rich high-SDI countries. Addressing persistent inequities necessitates tailored regional strategies: optimizing resource allocation in high-SDI settings and expanding low-cost screening and treatment in low-SDI regions, alongside prioritizing neonatal care and risk mitigation to achieve global health equity in pediatric PAH.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Pediatric Cardiology
Pediatric Cardiology 医学-小儿科
CiteScore
3.30
自引率
6.20%
发文量
258
审稿时长
12 months
期刊介绍: The editor of Pediatric Cardiology welcomes original manuscripts concerning all aspects of heart disease in infants, children, and adolescents, including embryology and anatomy, physiology and pharmacology, biochemistry, pathology, genetics, radiology, clinical aspects, investigative cardiology, electrophysiology and echocardiography, and cardiac surgery. Articles which may include original articles, review articles, letters to the editor etc., must be written in English and must be submitted solely to Pediatric Cardiology.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信