凝固酶阴性葡萄球菌的糖肽异耐药：系统综述和荟萃分析。

IF 3.8 4区医学 Q2 IMMUNOLOGY

Open Forum Infectious Diseases Pub Date : 2025-08-14 eCollection Date: 2025-08-01 DOI:10.1093/ofid/ofaf494

Clark D Russell, Min Ke, Simon Dewar, Naomi J Gadsby, Ewan S Olson, Mandy Wootton

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引用次数: 0

摘要

我们发现凝固酶阴性葡萄球菌中糖肽异耐药的患病率很高（41.4%，95%置信区间30.7-52.9；meta分析包括n = 1432株）。异耐药与甲氧西林耐药有关，不需要糖肽暴露，并且可能在侵袭性感染分离株中更为普遍。异源耐药可能是con感染治疗失败的一个未被充分认识的原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Glycopeptide Heteroresistance Among Coagulase-Negative Staphylococci: A Systematic Review and Meta-analysis.

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Glycopeptide Heteroresistance Among Coagulase-Negative Staphylococci: A Systematic Review and Meta-analysis.

We identified a high prevalence of glycopeptide heteroresistance amongst coagulase-negative staphylococci (41.4%, 95% confidence interval 30.7-52.9; meta-analysis including n = 1432 isolates). Heteroresistance was associated with methicillin resistance, did not require glycopeptide exposure, and may be more prevalent among isolates from invasive infections. Heteroresistance may represent an under-appreciated reason for treatment failure of CoNS infections.

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来源期刊

Open Forum Infectious Diseases Medicine-Neurology (clinical)

CiteScore

6.70

自引率

4.80%

发文量

630

审稿时长

9 weeks

期刊介绍： Open Forum Infectious Diseases provides a global forum for the publication of clinical, translational, and basic research findings in a fully open access, online journal environment. The journal reflects the broad diversity of the field of infectious diseases, and focuses on the intersection of biomedical science and clinical practice, with a particular emphasis on knowledge that holds the potential to improve patient care in populations around the world. Fully peer-reviewed, OFID supports the international community of infectious diseases experts by providing a venue for articles that further the understanding of all aspects of infectious diseases.