E Gürbüz, A Kara, Ş Yürektürk, M Saygın, S Aydemir, A Ekici
{"title":"慢性弓形虫病在人类药物滥用中的作用及其对多巴胺水平的影响。","authors":"E Gürbüz, A Kara, Ş Yürektürk, M Saygın, S Aydemir, A Ekici","doi":"10.4103/njcp.njcp_669_24","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Toxoplasma gondii is a common parasitic infection agent that, in its chronic phase, forms persistent tissue cysts in neuronal cells, potentially leading to neurological and behavioral alterations.</p><p><strong>Aim: </strong>To investigate the role of chronic toxoplasmosis in human substance abuse and investigate its effect on dopamine levels, which is associated with substance abuse.</p><p><strong>Materials and methods: </strong>The study was designed with a substance abuse group comprising 90 patients with substance addiction and a control group consisting of 75 individuals without substance addiction. The substance abuse group consisted of patients who were addicted to alcohol, cannabis, cocaine, heroin, or amphetamines. Anti-Toxoplasma gondii IgG and dopamine levels in the blood sera and anti-T. gondii immunoglobulin G (IgG) levels in the blood samples taken from the participants were analyzed via enzyme-linked immunosorbent assay.</p><p><strong>Results: </strong>T. gondii IgG was detected in 52 (57.8%) of 90 patients in the substance abuse group and 22 (29.3%) of 75 patients in the control group. There was a statistically significant relationship between T. gondii positivity and substance addiction (P = 0.001). However, no correlation was found between T. gondii positivity and the subgroups for the addiction type, criminal offense, imprisonment, or suicide attempt. Dopamine levels were statistically different between the groups. In the pairwise comparison of the groups, the dopamine levels in the T. gondii-positive substance abuse group were lower than in the other three groups, and this was statistically significant.</p><p><strong>Conclusion: </strong>In conclusion, the prevalence of T. gondii was higher in those with substance addiction than in those without. The fact that T. gondii alters dopamine levels was among the results. Since T. gondii can affect some behaviors of the host through changes in neurotransmitter levels, it was concluded that there is a significant relationship between T. gondii infection and substance abuse.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 8","pages":"897-903"},"PeriodicalIF":0.7000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Role of Chronic Toxoplasmosis in Substance Abuse in Humans and its Effect on Dopamine Levels.\",\"authors\":\"E Gürbüz, A Kara, Ş Yürektürk, M Saygın, S Aydemir, A Ekici\",\"doi\":\"10.4103/njcp.njcp_669_24\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Toxoplasma gondii is a common parasitic infection agent that, in its chronic phase, forms persistent tissue cysts in neuronal cells, potentially leading to neurological and behavioral alterations.</p><p><strong>Aim: </strong>To investigate the role of chronic toxoplasmosis in human substance abuse and investigate its effect on dopamine levels, which is associated with substance abuse.</p><p><strong>Materials and methods: </strong>The study was designed with a substance abuse group comprising 90 patients with substance addiction and a control group consisting of 75 individuals without substance addiction. The substance abuse group consisted of patients who were addicted to alcohol, cannabis, cocaine, heroin, or amphetamines. Anti-Toxoplasma gondii IgG and dopamine levels in the blood sera and anti-T. gondii immunoglobulin G (IgG) levels in the blood samples taken from the participants were analyzed via enzyme-linked immunosorbent assay.</p><p><strong>Results: </strong>T. gondii IgG was detected in 52 (57.8%) of 90 patients in the substance abuse group and 22 (29.3%) of 75 patients in the control group. There was a statistically significant relationship between T. gondii positivity and substance addiction (P = 0.001). However, no correlation was found between T. gondii positivity and the subgroups for the addiction type, criminal offense, imprisonment, or suicide attempt. Dopamine levels were statistically different between the groups. In the pairwise comparison of the groups, the dopamine levels in the T. gondii-positive substance abuse group were lower than in the other three groups, and this was statistically significant.</p><p><strong>Conclusion: </strong>In conclusion, the prevalence of T. gondii was higher in those with substance addiction than in those without. The fact that T. gondii alters dopamine levels was among the results. Since T. gondii can affect some behaviors of the host through changes in neurotransmitter levels, it was concluded that there is a significant relationship between T. gondii infection and substance abuse.</p>\",\"PeriodicalId\":19431,\"journal\":{\"name\":\"Nigerian Journal of Clinical Practice\",\"volume\":\"28 8\",\"pages\":\"897-903\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2025-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nigerian Journal of Clinical Practice\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.4103/njcp.njcp_669_24\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/8/30 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nigerian Journal of Clinical Practice","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4103/njcp.njcp_669_24","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/30 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Role of Chronic Toxoplasmosis in Substance Abuse in Humans and its Effect on Dopamine Levels.
Background: Toxoplasma gondii is a common parasitic infection agent that, in its chronic phase, forms persistent tissue cysts in neuronal cells, potentially leading to neurological and behavioral alterations.
Aim: To investigate the role of chronic toxoplasmosis in human substance abuse and investigate its effect on dopamine levels, which is associated with substance abuse.
Materials and methods: The study was designed with a substance abuse group comprising 90 patients with substance addiction and a control group consisting of 75 individuals without substance addiction. The substance abuse group consisted of patients who were addicted to alcohol, cannabis, cocaine, heroin, or amphetamines. Anti-Toxoplasma gondii IgG and dopamine levels in the blood sera and anti-T. gondii immunoglobulin G (IgG) levels in the blood samples taken from the participants were analyzed via enzyme-linked immunosorbent assay.
Results: T. gondii IgG was detected in 52 (57.8%) of 90 patients in the substance abuse group and 22 (29.3%) of 75 patients in the control group. There was a statistically significant relationship between T. gondii positivity and substance addiction (P = 0.001). However, no correlation was found between T. gondii positivity and the subgroups for the addiction type, criminal offense, imprisonment, or suicide attempt. Dopamine levels were statistically different between the groups. In the pairwise comparison of the groups, the dopamine levels in the T. gondii-positive substance abuse group were lower than in the other three groups, and this was statistically significant.
Conclusion: In conclusion, the prevalence of T. gondii was higher in those with substance addiction than in those without. The fact that T. gondii alters dopamine levels was among the results. Since T. gondii can affect some behaviors of the host through changes in neurotransmitter levels, it was concluded that there is a significant relationship between T. gondii infection and substance abuse.
期刊介绍:
The Nigerian Journal of Clinical Practice is a Monthly peer-reviewed international journal published by the Medical and Dental Consultants’ Association of Nigeria. The journal’s full text is available online at www.njcponline.com. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository. The journal makes a token charge for submission, processing and publication of manuscripts including color reproduction of photographs.