慢性弓形虫病在人类药物滥用中的作用及其对多巴胺水平的影响。

IF 0.7 4区 医学 Q3 MEDICINE, GENERAL & INTERNAL
Nigerian Journal of Clinical Practice Pub Date : 2025-08-01 Epub Date: 2025-08-30 DOI:10.4103/njcp.njcp_669_24
E Gürbüz, A Kara, Ş Yürektürk, M Saygın, S Aydemir, A Ekici
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引用次数: 0

摘要

背景:刚地弓形虫是一种常见的寄生虫感染病原体,在其慢性期,在神经元细胞中形成持久的组织囊肿,可能导致神经和行为改变。目的:探讨慢性弓形虫病在人类药物滥用中的作用,并探讨其对多巴胺水平的影响。材料与方法:本研究采用药物滥用组(90例物质成瘾患者)和对照组(75例非物质成瘾患者)设计。药物滥用组包括对酒精、大麻、可卡因、海洛因或安非他明上瘾的患者。血清抗刚地弓形虫IgG和多巴胺水平及抗t。通过酶联免疫吸附法分析参与者血液样本中的弓形虫免疫球蛋白G (IgG)水平。结果:药物滥用组90例中检出弓形虫IgG 52例(57.8%),对照组75例中检出22例(29.3%)。弓形虫阳性与物质成瘾有统计学意义(P = 0.001)。然而,弓形虫阳性与成瘾类型、犯罪、监禁或自杀企图的亚组之间没有相关性。两组之间的多巴胺水平有统计学差异。在两组的两两比较中,弓形虫阳性药物滥用组的多巴胺水平低于其他三组,这有统计学意义。结论:药物依赖人群中弓形虫患病率高于非药物依赖人群。结果之一就是弓形虫改变多巴胺水平。由于弓形虫可以通过改变神经递质水平影响宿主的某些行为,因此我们认为弓形虫感染与药物滥用之间存在显著关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role of Chronic Toxoplasmosis in Substance Abuse in Humans and its Effect on Dopamine Levels.

Background: Toxoplasma gondii is a common parasitic infection agent that, in its chronic phase, forms persistent tissue cysts in neuronal cells, potentially leading to neurological and behavioral alterations.

Aim: To investigate the role of chronic toxoplasmosis in human substance abuse and investigate its effect on dopamine levels, which is associated with substance abuse.

Materials and methods: The study was designed with a substance abuse group comprising 90 patients with substance addiction and a control group consisting of 75 individuals without substance addiction. The substance abuse group consisted of patients who were addicted to alcohol, cannabis, cocaine, heroin, or amphetamines. Anti-Toxoplasma gondii IgG and dopamine levels in the blood sera and anti-T. gondii immunoglobulin G (IgG) levels in the blood samples taken from the participants were analyzed via enzyme-linked immunosorbent assay.

Results: T. gondii IgG was detected in 52 (57.8%) of 90 patients in the substance abuse group and 22 (29.3%) of 75 patients in the control group. There was a statistically significant relationship between T. gondii positivity and substance addiction (P = 0.001). However, no correlation was found between T. gondii positivity and the subgroups for the addiction type, criminal offense, imprisonment, or suicide attempt. Dopamine levels were statistically different between the groups. In the pairwise comparison of the groups, the dopamine levels in the T. gondii-positive substance abuse group were lower than in the other three groups, and this was statistically significant.

Conclusion: In conclusion, the prevalence of T. gondii was higher in those with substance addiction than in those without. The fact that T. gondii alters dopamine levels was among the results. Since T. gondii can affect some behaviors of the host through changes in neurotransmitter levels, it was concluded that there is a significant relationship between T. gondii infection and substance abuse.

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来源期刊
Nigerian Journal of Clinical Practice
Nigerian Journal of Clinical Practice MEDICINE, GENERAL & INTERNAL-
CiteScore
1.40
自引率
0.00%
发文量
275
审稿时长
4-8 weeks
期刊介绍: The Nigerian Journal of Clinical Practice is a Monthly peer-reviewed international journal published by the Medical and Dental Consultants’ Association of Nigeria. The journal’s full text is available online at www.njcponline.com. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository. The journal makes a token charge for submission, processing and publication of manuscripts including color reproduction of photographs.
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