40Fp8疫苗株是安全的，可保护怀孕母羊免受致命的裂谷热病毒攻击。

IF 6.5 1区医学 Q1 IMMUNOLOGY

NPJ Vaccines Pub Date : 2025-08-29 DOI:10.1038/s41541-025-01250-6

Belén Borrego, Celia Alonso, Sandra Moreno, Eva Calvo-Pinilla, Gema Lorenzo, Pedro J Sánchez-Cordón, Alejandro Brun

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引用次数: 0

摘要

在本研究中，我们评估了RVFV-40Fp8减毒株在自然宿主（未怀孕母羊）和高度易感宿主感染模型（如怀孕前三分之一的怀孕母羊）中的免疫原性、安全性和保护效果。我们的研究结果证实了40Fp8在未怀孕和怀孕母羊中的免疫原性，以及即使在怀孕母羊中接种高剂量疫苗后也没有对胎儿造成损害。此外，通过对接种疫苗和未接种疫苗的妊娠母羊的血液、血清和不同组织样本进行比较评估，母羊及其胎儿可免受RVFV-56/74毒株的攻击。这些结果证实了40Fp8作为裂谷热减毒活疫苗候选疫苗的潜在用途，并为进一步的临床开发铺平了道路。

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The 40Fp8 vaccine strain is safe and protects pregnant ewes from a virulent RVFV challenge.

In the present study, we evaluated the immunogenicity, safety and protective efficacy of the attenuated RVFV-40Fp8 strain in natural hosts (non-pregnant ewes) and in a highly susceptible host infection model such as pregnant ewes in the first third of pregnancy. Our results confirm the immunogenicity of 40Fp8 administration in non-pregnant and pregnant ewes, as well as the absence of foetal damage even after a high-dose vaccination regime in pregnant ewes. In addition, the ewes and their foetuses were protected against a virulent RVFV-56/74 strain challenge, as shown by comparative evaluation of blood, serum and different tissue samples from vaccinated and non-vaccinated pregnant ewes. These results confirm the potential use of 40Fp8 as a RVF live-attenuated vaccine candidate and pave the way for further clinical developments.

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来源期刊

NPJ Vaccines Immunology and Microbiology-Immunology

CiteScore

11.90

自引率

4.30%

发文量

146

审稿时长

11 weeks

期刊介绍： Online-only and open access, npj Vaccines is dedicated to highlighting the most important scientific advances in vaccine research and development.