MACC1-AS1:肿瘤生物学领域的一颗新星,医学前景光明。

IF 4.7 2区 医学 Q2 CELL BIOLOGY
Li Dong, Weidong Li, Wei Zhu, YaMin Sun
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引用次数: 0

摘要

长链非编码rna作为调制剂,对多种生物功能具有重要影响。它们在基因之间形成了广泛的通讯网络,并对各种人类疾病,特别是癌症的病理生理有贡献。越来越多的研究表明,lncrna作为肿瘤发生的启动子或抑制剂,与癌症的发生和发展有着复杂的联系。MACC1-AS1是一种新发现的LncRNA,在各种类型的人类肿瘤中异常表达。肿瘤较大、肿瘤分期较晚、淋巴结转移、总生存率较低等不良临床特征与MACC1-AS1过表达有关。MACC1-AS1发挥复杂的调控功能:它作为竞争性RNA,与多种蛋白质相互作用,影响多种途径,导致肿瘤的发展。必须注意的是,传统化疗药物的疗效下降,这降低了癌症治疗的疗效。正在进行的研究已经强调了MACC1-AS1的多方面功能,因此,需要揭示其确切的分子机制。在这篇综述中,我们探讨了MACC1-AS1作为潜在的癌症治疗靶点和生物标志物的意义。本研究可能在该领域的发展中发挥重要作用,并证实其潜在的临床适用性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
MACC1-AS1: An Emerging Star in The Field of Tumor Biology with Bright Futures in Medicine.

Long non-coding RNAs act as modulators, with significant influence on a wide array of biological functions. They form an extensive communication network between genes and contribute to the pathophysiology of various human diseases, especially cancer. A growing body of research has demonstrated that LncRNAs, acting either as promoters or inhibitors of oncogenesis, are intricately linked to the initiation and progression of cancer. MACC1-AS1 is a newly identified LncRNA that is abnormally expressed in various types of human tumors. Poor clinical characteristics, such as larger tumor size, advanced tumor stage, lymph node metastasis, and a lower overall survival rate, are linked to overexpression of MACC1-AS1. MACC1-AS1 exerts a complex regulatory function: it acts as a competitive RNA, interacts with multiple proteins, and influences diverse pathways, leading to tumor development. It is essential to note the decreased efficacy of conventional chemotherapy drugs, which diminishes the efficacy of cancer treatment. Ongoing research has been highlighting the multifaceted functions of MACC1-AS1, and thus, it is required to unravel its exact molecular mechanisms. In this overarching review, we explore the significance of MACC1-AS1 as a potential cancer treatment target and biomarker. This study can potentially play an important role in the advancement of the field and confirm its potential clinical applicability.

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来源期刊
Molecular Cancer Research
Molecular Cancer Research 医学-细胞生物学
CiteScore
9.90
自引率
0.00%
发文量
280
审稿时长
4-8 weeks
期刊介绍: Molecular Cancer Research publishes articles describing novel basic cancer research discoveries of broad interest to the field. Studies must be of demonstrated significance, and the journal prioritizes analyses performed at the molecular and cellular level that reveal novel mechanistic insight into pathways and processes linked to cancer risk, development, and/or progression. Areas of emphasis include all cancer-associated pathways (including cell-cycle regulation; cell death; chromatin regulation; DNA damage and repair; gene and RNA regulation; genomics; oncogenes and tumor suppressors; signal transduction; and tumor microenvironment), in addition to studies describing new molecular mechanisms and interactions that support cancer phenotypes. For full consideration, primary research submissions must provide significant novel insight into existing pathway functions or address new hypotheses associated with cancer-relevant biologic questions.
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