自主跑步改善膝骨关节炎患者前扣带皮质突触变性。

IF 2.9 3区 医学 Q2 NEUROSCIENCES
Ryo Miyake, Manabu Yamanaka, Wataru Taniguchi, Naoko Nishio, Yuki Matsuyama, Takeru Ueno, Yuta Kaimochi, Terumasa Nakatsuka, Hiroshi Yamada
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引用次数: 0

摘要

膝关节骨性关节炎(膝OA)引起慢性疼痛,累及周围组织、脊髓和大脑。神经性疼痛导致前扣带皮层突触可塑性的改变。然而,这种变化是否发生在膝关节OA小鼠身上,以及它们与运动治疗的关系尚不清楚。因此,本研究采用电生理和行为方法对这些方面进行了研究。我们发现在膝OA小鼠的ACC中没有诱导前或后长期增强(LTP)。ZD7288和zeta抑制肽(ZIP)的使用降低了诱发兴奋性突触后电流的振幅,表明ACC中突触可塑性已经发生了变化。微量注射ZD7288和ZIP可改善疼痛逃避和焦虑样行为。自愿跑步运动可诱导膝关节炎小鼠ltp发生前和发生后,并改善这些行为。膝关节OA的运动治疗可能改变ACC的突触可塑性,有助于行为改善。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Voluntary running improves synaptic degeneration of the anterior cingulate cortex in knee osteoarthritis.

Osteoarthritis of the knee (knee OA) causes chronic pain involving peripheral tissues, the spinal cord, and the brain. Neuropathic pain leads to changes in synaptic plasticity in the anterior cingulate cortex (ACC). However, whether such changes occur in knee OA mice and their association with exercise therapy remains unclear. Therefore, this study investigated these aspects using electrophysiological and behavioral approaches. We found no induction of pre- or post-long-term potentiation (LTP) in the ACC of knee OA mice. Application of ZD7288 and zeta inhibitory peptide (ZIP) reduced the amplitude of evoked excitatory postsynaptic currents, indicating pre-existing changes in synaptic plasticity in the ACC. Microinjection of ZD7288 and ZIP improved pain-escape and anxiety-like behaviors. Voluntary running exercise induced pre- and post-LTP and improved these behaviors in knee OA mice. Exercise therapy for knee OA may alter synaptic plasticity in the ACC, contributing to behavioral improvements.

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来源期刊
Molecular Brain
Molecular Brain NEUROSCIENCES-
CiteScore
7.30
自引率
0.00%
发文量
97
审稿时长
>12 weeks
期刊介绍: Molecular Brain is an open access, peer-reviewed journal that considers manuscripts on all aspects of studies on the nervous system at the molecular, cellular, and systems level providing a forum for scientists to communicate their findings. Molecular brain research is a rapidly expanding research field in which integrative approaches at the genetic, molecular, cellular and synaptic levels yield key information about the physiological and pathological brain. These studies involve the use of a wide range of modern techniques in molecular biology, genomics, proteomics, imaging and electrophysiology.
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