发作性睡患者与快速眼动相关的阻塞性睡眠呼吸暂停的患病率及相关因素

IF 3.4 2区医学 Q2 CLINICAL NEUROLOGY

Nature and Science of Sleep Pub Date : 2025-08-25 eCollection Date: 2025-01-01 DOI:10.2147/NSS.S554593

Hamza O Dhafar, Ali A Awadh, Salih A Aleissi, Galal Eldin Abbas Eltayeb, Samar Z Nashwan, Ahmed S BaHammam

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引用次数: 0

摘要

目的：关于发作性睡病患者中与快速眼动（REM）相关的阻塞性睡眠呼吸暂停（REM- osa）的患病率及其相关因素的数据仍然有限。本研究旨在评估发作性睡病患者中OSA和REM-OSA的患病率及独立相关因素，并比较发作性睡病患者与非发作性睡病患者匹配对照中REM-OSA的分布。患者和方法：本回顾性研究前瞻性收集了190例成人发作性睡病患者（发作性睡病1型[NT1] = 119，发作性睡病2型[NT2] = 71），这些患者于2007年1月至2022年2月在沙特国王大学医学城大学睡眠障碍中心接受了多导睡眠仪和多次睡眠潜伏期试验。REM-OSA定义为呼吸暂停低通气指数(AHI)≥5，AHI- rem /AHI-非快速眼动(NREM)≥2,AHI-NREM 10.5分钟。106例发作性睡病患者被诊断为OSA。选取年龄、性别、AHI和BMI相匹配的122例无发作性睡的OSA患者作为对照组进行比较。Logistic回归确定了与OSA和REM-OSA相关的独立因素。结果：发作性睡病患者中有106例（55.8%）诊断为OSA。这些病例中有26.4%存在REM-OSA， NT2的患病率（30%）略高于NT1（24%）。发作性睡病组的REM-OSA患病率高于对照组（26.4% vs 17.2%, OR: 1.73, 95% CI: 0.91-3.27, p = 0.09）。男性性别、BMI和觉醒指数是发作性睡症患者的OSA的独立相关因素。REM- osa与唤醒指数和REM睡眠持续时间独立相关。结论：OSA和REM-OSA在发作性睡病患者中较为常见。与对照组相比，发作性睡病组的REM-OSA更为普遍，这表明发作性睡病和REM-OSA之间存在潜在关联，值得在更大的队列中进行研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Prevalence and Factors Associated with Rapid Eye Movement-Related Obstructive Sleep Apnea in Patients with Narcolepsy.

查看原文本刊更多论文

Prevalence and Factors Associated with Rapid Eye Movement-Related Obstructive Sleep Apnea in Patients with Narcolepsy.

Purpose: Data on the prevalence and correlates of rapid eye movement (REM)-related obstructive sleep apnea (REM-OSA) in narcolepsy remains limited. This study aimed to assess the prevalence and independent associated factors with OSA and REM-OSA in patients with narcolepsy, and to compare the distribution of REM-OSA between patients with narcolepsy and matched controls without narcolepsy.

Patients and methods: This retrospective study of a prospectively collected cohort included 190 adult patients with narcolepsy (narcolepsy type 1 [NT1] = 119, narcolepsy type 2 [NT2] = 71) who underwent polysomnography and multiple sleep latency test at the University Sleep Disorders Center, King Saud University Medical City, between January 2007 and February 2022. REM-OSA was defined as an apnea-hypopnea index (AHI) ≥5, AHI-REM/AHI-non-rapid eye movement (NREM) ≥2, AHI-NREM <8, and REM sleep duration >10.5 minutes. A total of 106 patients with narcolepsy were diagnosed with OSA. A control group of 122 patients with OSA but without narcolepsy, matched by age, sex, AHI, and BMI, was used for comparison. Logistic regression identified independent associated factors with OSA and REM-OSA.

Results: OSA was diagnosed in 106 patients with narcolepsy (55.8%). REM-OSA was present in 26.4% of these cases, with a slightly higher prevalence in NT2 (30%) than in NT1 (24%). REM-OSA showed a trend toward higher prevalence in the narcolepsy group compared to controls (26.4% vs 17.2%, OR: 1.73, 95% CI: 0.91-3.27, p = 0.09). Male sex, BMI, and arousal index were independent correlates of OSA among patients with narcolepsy. REM-OSA was independently associated with arousal index and REM sleep duration.

Conclusion: OSA and REM-OSA are common in patients with narcolepsy. REM-OSA was more prevalent in the narcolepsy group than in matched controls, suggesting a potential association between narcolepsy and REM-OSA that warrants investigation in larger cohorts.

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来源期刊

Nature and Science of Sleep Neuroscience-Behavioral Neuroscience

CiteScore

5.70

自引率

5.90%

发文量

245

审稿时长

16 weeks

期刊介绍： Nature and Science of Sleep is an international, peer-reviewed, open access journal covering all aspects of sleep science and sleep medicine, including the neurophysiology and functions of sleep, the genetics of sleep, sleep and society, biological rhythms, dreaming, sleep disorders and therapy, and strategies to optimize healthy sleep. Specific topics covered in the journal include: The functions of sleep in humans and other animals Physiological and neurophysiological changes with sleep The genetics of sleep and sleep differences The neurotransmitters, receptors and pathways involved in controlling both sleep and wakefulness Behavioral and pharmacological interventions aimed at improving sleep, and improving wakefulness Sleep changes with development and with age Sleep and reproduction (e.g., changes across the menstrual cycle, with pregnancy and menopause) The science and nature of dreams Sleep disorders Impact of sleep and sleep disorders on health, daytime function and quality of life Sleep problems secondary to clinical disorders Interaction of society with sleep (e.g., consequences of shift work, occupational health, public health) The microbiome and sleep Chronotherapy Impact of circadian rhythms on sleep, physiology, cognition and health Mechanisms controlling circadian rhythms, centrally and peripherally Impact of circadian rhythm disruptions (including night shift work, jet lag and social jet lag) on sleep, physiology, cognition and health Behavioral and pharmacological interventions aimed at reducing adverse effects of circadian-related sleep disruption Assessment of technologies and biomarkers for measuring sleep and/or circadian rhythms Epigenetic markers of sleep or circadian disruption.