经宫颈息肉切除术联合左炔诺孕酮释放宫内系统治疗子宫内膜息肉的疗效：一项随机对照试验。

IF 2 4区医学 Q2 SURGERY

Minimally Invasive Therapy & Allied Technologies Pub Date : 2025-09-02 DOI:10.1080/13645706.2025.2542329

Yu-Jie Zhang, Xiao-Dong Wang, Mei Shan, Qing-Ling Lu, Ting-Ting Tian

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引用次数: 0

摘要

背景：本研究旨在比较经宫颈息肉切除术（TCRP）联合左炔诺孕酮释放宫内系统（LNG-IUS）或口服地沙孕酮炔雌醇片（DET）治疗子宫内膜息肉（EMP）的临床疗效和预后。方法：将100例接受TCRP治疗的EMP患者分为LNG-IUS组（n = 50）和DET组（n = 50）。术前和术后监测血红蛋白、子宫内膜厚度、卵泡刺激素、E2和LH水平。在12个月内评估临床症状改善、不良反应和复发率。结果：两种治疗均可改善血红蛋白水平，降低子宫内膜厚度，但LNG-IUS组疗效更佳。12个月时，痛经（72.0% vs. 34.0%）、月经周期异常（60.0% vs. 24.0%）、出血量（52.0% vs. 30.0%）的改善率更高，不良反应（4.0% vs. 24.0%）更少，复发率（0% vs. 16.0%）更低，均为p结论：LNG-IUS联合TCRP在减少子宫内膜厚度、减轻症状、降低副作用、预防EMP复发方面优于DET。

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Efficacy of transcervical resection of polyp combined with levonorgestrel-releasing intrauterine system in the treatment of endometrial polyps: a randomized controlled trial.

Background: This study aimed to compare the clinical efficacy and prognosis of transcervical resection of polyp (TCRP) combined with levonorgestrel-releasing intrauterine system (LNG-IUS) or oral desogestrel and ethinyl estradiol tablets (DET) in patients with endometrial polyps (EMP).

Methods: A total of 100 EMP patients undergoing TCRP were divided into LNG-IUS (n = 50) and DET (n = 50) groups. Hemoglobin, endometrial thickness, FSH, E2, and LH levels were monitored pre-surgery and post-surgery. Clinical symptom improvement, adverse reactions, and recurrence rates were assessed over 12 months.

Results: Both treatments improved hemoglobin levels and reduced endometrial thickness, but the LNG-IUS group showed superior outcomes. At 12 months, it achieved higher improvement rates for dysmenorrhea (72.0% vs. 34.0%), abnormal cycles (60.0% vs. 24.0%), and blood loss (52.0% vs. 30.0%), with fewer adverse reactions (4.0% vs. 24.0%) and a lower recurrence rate (0% vs. 16.0%, all p < .05).

Conclusions: LNG-IUS with TCRP outperformed DET in reducing endometrial thickness, alleviating symptoms, lowering side effects, and preventing recurrence in EMP.

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来源期刊

Minimally Invasive Therapy & Allied Technologies 医学-外科

CiteScore

3.80

自引率

5.90%

发文量

审稿时长

6-12 weeks

期刊介绍： Minimally Invasive Therapy and Allied Technologies (MITAT) is an international forum for endoscopic surgeons, interventional radiologists and industrial instrument manufacturers. It is the official journal of the Society for Medical Innovation and Technology (SMIT) whose membership includes representatives from a broad spectrum of medical specialities, instrument manufacturing and research. The journal brings the latest developments and innovations in minimally invasive therapy to its readers. What makes Minimally Invasive Therapy and Allied Technologies unique is that we publish one or two special issues each year, which are devoted to a specific theme. Key topics covered by the journal include: interventional radiology, endoscopic surgery, imaging technology, manipulators and robotics for surgery and education and training for MIS.