女性和男性激素依赖性恶性肿瘤:长链非编码rna的作用。

IF 3.5 4区 医学 Q2 ONCOLOGY
Yahia Elgharib, Karim Medhat, Fayrouz Fouad, Faten Elgharib, Ekram Saleh
{"title":"女性和男性激素依赖性恶性肿瘤:长链非编码rna的作用。","authors":"Yahia Elgharib, Karim Medhat, Fayrouz Fouad, Faten Elgharib, Ekram Saleh","doi":"10.1007/s12032-025-03001-y","DOIUrl":null,"url":null,"abstract":"<p><p>Since their discovery, long non-coding RNAs (lncRNAs) have emerged as critical regulators of diverse biological processes across various tissues. Their dysregulation has been strongly linked to cancer progression. LncRNAs influence key aspects of tumor biology, including cell proliferation, invasion, metastasis, apoptosis, and therapeutic resistance, acting either as oncogenes or tumor suppressors. In hormone-dependent malignancies such as breast and prostate cancers, lncRNAs play pivotal roles by modulating hormone signaling pathways and regulating the expression and activity of hormone receptors, including estrogen (ER), progesterone (PR), and androgen receptors (AR). Despite increasing evidence of their involvement, many of these lncRNAs remain poorly characterized, and their potential as diagnostic markers or therapeutic targets is still under investigation.This review aims to critically synthesize recent advances in the understanding of lncRNAs in hormone-dependent cancers, with a focus on their oncogenic and tumor-suppressive roles, involvement in drug resistance, and clinical relevance. By highlighting both established findings and areas requiring further research, we seek to provide a comprehensive and insightful overview that can inform future therapeutic strategies and translational applications.</p>","PeriodicalId":18433,"journal":{"name":"Medical Oncology","volume":"42 10","pages":"444"},"PeriodicalIF":3.5000,"publicationDate":"2025-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Female and male hormonal-dependent malignancies: the role of long non-coding RNAs.\",\"authors\":\"Yahia Elgharib, Karim Medhat, Fayrouz Fouad, Faten Elgharib, Ekram Saleh\",\"doi\":\"10.1007/s12032-025-03001-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Since their discovery, long non-coding RNAs (lncRNAs) have emerged as critical regulators of diverse biological processes across various tissues. Their dysregulation has been strongly linked to cancer progression. LncRNAs influence key aspects of tumor biology, including cell proliferation, invasion, metastasis, apoptosis, and therapeutic resistance, acting either as oncogenes or tumor suppressors. In hormone-dependent malignancies such as breast and prostate cancers, lncRNAs play pivotal roles by modulating hormone signaling pathways and regulating the expression and activity of hormone receptors, including estrogen (ER), progesterone (PR), and androgen receptors (AR). Despite increasing evidence of their involvement, many of these lncRNAs remain poorly characterized, and their potential as diagnostic markers or therapeutic targets is still under investigation.This review aims to critically synthesize recent advances in the understanding of lncRNAs in hormone-dependent cancers, with a focus on their oncogenic and tumor-suppressive roles, involvement in drug resistance, and clinical relevance. By highlighting both established findings and areas requiring further research, we seek to provide a comprehensive and insightful overview that can inform future therapeutic strategies and translational applications.</p>\",\"PeriodicalId\":18433,\"journal\":{\"name\":\"Medical Oncology\",\"volume\":\"42 10\",\"pages\":\"444\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2025-08-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medical Oncology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s12032-025-03001-y\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical Oncology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s12032-025-03001-y","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

自发现以来,长链非编码rna (lncrna)已成为各种组织中多种生物过程的关键调节因子。它们的失调与癌症的发展密切相关。LncRNAs影响肿瘤生物学的关键方面,包括细胞增殖、侵袭、转移、凋亡和治疗耐药性,作为致癌基因或肿瘤抑制因子。在激素依赖性恶性肿瘤如乳腺癌和前列腺癌中,lncrna通过调节激素信号通路和调节激素受体的表达和活性发挥关键作用,包括雌激素(ER)、孕激素(PR)和雄激素受体(AR)。尽管越来越多的证据表明这些lncrna参与其中,但许多lncrna的特征仍然很差,它们作为诊断标记物或治疗靶点的潜力仍在研究中。本综述旨在批判性地综合lncrna在激素依赖性癌症中的最新进展,重点关注其致癌和肿瘤抑制作用,参与耐药和临床相关性。通过强调已建立的发现和需要进一步研究的领域,我们寻求提供一个全面而深刻的概述,可以为未来的治疗策略和转化应用提供信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Female and male hormonal-dependent malignancies: the role of long non-coding RNAs.

Since their discovery, long non-coding RNAs (lncRNAs) have emerged as critical regulators of diverse biological processes across various tissues. Their dysregulation has been strongly linked to cancer progression. LncRNAs influence key aspects of tumor biology, including cell proliferation, invasion, metastasis, apoptosis, and therapeutic resistance, acting either as oncogenes or tumor suppressors. In hormone-dependent malignancies such as breast and prostate cancers, lncRNAs play pivotal roles by modulating hormone signaling pathways and regulating the expression and activity of hormone receptors, including estrogen (ER), progesterone (PR), and androgen receptors (AR). Despite increasing evidence of their involvement, many of these lncRNAs remain poorly characterized, and their potential as diagnostic markers or therapeutic targets is still under investigation.This review aims to critically synthesize recent advances in the understanding of lncRNAs in hormone-dependent cancers, with a focus on their oncogenic and tumor-suppressive roles, involvement in drug resistance, and clinical relevance. By highlighting both established findings and areas requiring further research, we seek to provide a comprehensive and insightful overview that can inform future therapeutic strategies and translational applications.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Medical Oncology
Medical Oncology 医学-肿瘤学
CiteScore
4.20
自引率
2.90%
发文量
259
审稿时长
1.4 months
期刊介绍: Medical Oncology (MO) communicates the results of clinical and experimental research in oncology and hematology, particularly experimental therapeutics within the fields of immunotherapy and chemotherapy. It also provides state-of-the-art reviews on clinical and experimental therapies. Topics covered include immunobiology, pathogenesis, and treatment of malignant tumors.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信