eb病毒感染及其与系统性红斑狼疮的关系:系统回顾和荟萃分析。

IF 1.9 4区 医学 Q3 RHEUMATOLOGY
Lupus Pub Date : 2025-10-01 Epub Date: 2025-08-29 DOI:10.1177/09612033251371333
Shovit Ranjan, Sunil Kumar, Hrushikesh Nayak, Aditya K Panda
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引用次数: 0

摘要

系统性红斑狼疮(SLE)是一种慢性自身免疫性疾病,其特征是产生针对大多数器官系统并导致其功能障碍的自身抗体。SLE的确切病因尚不清楚;然而,遗传和环境因素被认为起着重要作用。病毒感染,特别是eb病毒(EBV),被认为是SLE发病的环境触发因素,然而,在研究和人群中观察到的结果仍然不一致。本研究采用荟萃分析方法探讨EBV感染在普通人群中的患病率及其在SLE发病机制中的作用。材料和方法检索PubMed、Scopus和ScienceDirect等数据库,根据预定的纳入和排除标准获得符合条件的研究。采用纽卡斯尔-渥太华量表(NOS)对符合条件的研究进行质量评价,采用综合meta分析(CMA) v4软件进行分析。采用漏斗图和Egger回归评价发表偏倚,采用Cochrane Q和I2统计量评价异质性。结果本研究共纳入28项研究,其中健康对照3926例,SLE患者2968例。EBV感染在健康对照组中普遍存在。在比较EBV DNA或抗体阳性的频率时,SLE患者的阳性率高于健康对照组,提示EBV感染是SLE发生的危险因素。此外,敏感性分析也显示meta分析是稳健的。结论大多数健康人曾暴露于eb病毒,感染可能是SLE发病的一个潜在危险因素。然而,未来的研究需要阐明EBV在SLE患者中再激活的可能机制,并研究潜在的预防措施,如抗病毒治疗,以减轻SLE风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Epstein-Barr virus infection and its association with systemic lupus erythematosus: Systematic review and meta-analysis.

BackgroundSystemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by the production of autoantibodies that target most of the organ systems and lead to their dysfunction. The exact etiology of SLE remains unclear; however, genetic and environmental factors are believed to play significant roles. Viral infections, particularly Epstein-Barr virus (EBV), have been implicated as environmental triggers in SLE pathogenesis however, the observations remained inconsistent among studies and populations. The present study uses a meta-analysis approach to explore the prevalence of EBV infection in the general population and their role in the pathogenesis of SLE.Materials and MethodsVarious databases such as PubMed, Scopus, and ScienceDirect were searched to obtain eligible studies based on predetermined inclusion and exclusion criteria. The Newcastle-Ottawa Scale (NOS) was used for quality assessment of the eligible studies, and Comprehensive Meta-Analysis (CMA) v4 software was used for the analysis. Publication bias was assessed with funnel plots and Egger's regression, while heterogeneity was evaluated with Cochrane Q and I2 statistics.ResultsIn the present investigation, a total of 28 studies comprising of 3926 healthy controls and 2968 SLE patients were included. EBV infections were prevalent in the healthy controls. While comparing the frequency of EBV DNA or antibodies positivity, the SLE patients had a higher positivity rate than the healthy controls, indicating that EBV infection is a risk factor for developing SLE. Furthermore, the sensitivity analysis also revealed that the meta-analysis was robust.ConclusionThe majority of healthy subjects were previously exposed to EBV, and the infection could be a potential risk factor in SLE pathogenesis. However, future research is required to elucidate the possible mechanisms of EBV reactivation in SLE patients and examine potential preventive measures, such as antiviral therapies, in mitigating SLE risk.

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来源期刊
Lupus
Lupus 医学-风湿病学
CiteScore
4.20
自引率
11.50%
发文量
225
审稿时长
1 months
期刊介绍: The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…
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