人类手指的血管舒缩。

IF 2.3 4区 医学 Q3 PERIPHERAL VASCULAR DISEASE
Pekka Talke, Jonathan S Maltz, Marcus Talke, Mika Scheinin, Mohamed Kheir Diab
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引用次数: 0

摘要

简介:我们描述了一种方法,通过这种方法可以记录清醒和麻醉的人类受试者的血管舒张,而不会受到其他自发血管振荡的明显干扰。方法:在三个独立的研究中,我们使用光容积脉搏图记录指尖的血管舒缩。在研究1中,我们对11名接受右美托咪定静脉输注的清醒受试者进行了化学交感神经切除术。在研究2中,我们对16名清醒的志愿者进行了4次渐进式静脉注射右美托咪定。在研究3中,我们同时记录了7例右美托咪定麻醉患者的6个手指的血管舒缩。分析了显示血管缓慢振荡的5分钟光容积脉搏波记录的频率和幅度。结果:研究1血管舒缩频率为0.025±0.008 Hz。在研究2中,右美托咪定输注的两个最高阶段血管舒缩频率分别为0.033±0.006 Hz和0.032±0.008 Hz。结论:我们观察到的血管振荡没有受到其他自发振荡的明显干扰,独立于神经活动(研究1),局部性质(研究3),与α -2-肾上腺素受体激活有关,与血管运动的已知特性一致。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Vasomotion in Human Fingers.

Introduction: We describe methods by which vasomotion can be recorded in awake and anesthetized human subjects without significant interference from other spontaneous vascular oscillations.

Methods: In three separate studies, we used photoplethysmography (PPG) to record vasomotion in fingertips. In Study 1, we induced chemical sympathectomy in the studied hand of 11 awake subjects who received intravenous dexmedetomidine infusions. In Study 2, we administered four progressively increasing intravenous dexmedetomidine infusions to 16 awake volunteers. In Study 3, we recorded vasomotion simultaneously from 6 fingers of 7 patients who were under dexmedetomidine-based anesthesia. Five-minute epochs of PPG recordings that displayed slow vascular oscillations were analyzed for frequency and amplitude.

Results: In Study 1, vasomotion frequencies were 0.025 ± 0.008 Hz. In Study 2, vasomotion frequencies were 0.033 ± 0.006 Hz, and 0.032 ± 0.008 Hz during the two highest dexmedetomidine infusion steps. In Study 3, vasomotion frequencies ranged from 0.020 to 0.037 Hz and were observed in all 6 fingers, with no synchrony between the six fingers.

Conclusion: The vascular oscillations we observed without significant interference from other spontaneous oscillations are independent of neural activity (Study 1), local in nature (Study 3), and associated with alpha-2-adrenoceptor activation, consistent with known properties of vasomotion.

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来源期刊
Journal of Vascular Research
Journal of Vascular Research 医学-生理学
CiteScore
3.40
自引率
0.00%
发文量
25
审稿时长
>12 weeks
期刊介绍: The ''Journal of Vascular Research'' publishes original articles and reviews of scientific excellence in vascular and microvascular biology, physiology and pathophysiology. The scope of the journal covers a broad spectrum of vascular and lymphatic research, including vascular structure, vascular function, haemodynamics, mechanics, cell signalling, intercellular communication, growth and differentiation. JVR''s ''Vascular Update'' series regularly presents state-of-the-art reviews on hot topics in vascular biology. Manuscript processing times are, consistent with stringent review, kept as short as possible due to electronic submission. All articles are published online first, ensuring rapid publication. The ''Journal of Vascular Research'' is the official journal of the European Society for Microcirculation. A biennial prize is awarded to the authors of the best paper published in the journal over the previous two years, thus encouraging young scientists working in the exciting field of vascular biology to publish their findings.
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