预测迷幻药作为速效抗抑郁药疗效的临床前调查的有效性评价。

IF 5.5 3区 医学 Q1 CLINICAL NEUROLOGY
S Clare Stanford
{"title":"预测迷幻药作为速效抗抑郁药疗效的临床前调查的有效性评价。","authors":"S Clare Stanford","doi":"10.1177/02698811251360754","DOIUrl":null,"url":null,"abstract":"<p><p>Each incident of failure of a novel drug to translate from preclinical experiments into the clinic increases the pressure to justify the use of animals in these experiments and for the interpretation of findings to be valid and convincing. This is especially the case with research of psychedelics, because they have already been tested extensively in humans. One reason for failure to translate is that preclinical research findings and conclusions are rarely, if ever, confirmed independently. Another is an incautious interpretation of the validity of the animal models that are used, in respect of their relevance to the human disorder of interest and its treatment. This article discusses both these points in the context of preclinical investigations of psychedelics as fast-acting antidepressants, but the generic points are relevant to other human disorders as well.</p>","PeriodicalId":16892,"journal":{"name":"Journal of Psychopharmacology","volume":" ","pages":"2698811251360754"},"PeriodicalIF":5.5000,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Appraisal of the validity of preclinical investigations to predict the efficacy of psychedelic drugs as fast-acting antidepressants.\",\"authors\":\"S Clare Stanford\",\"doi\":\"10.1177/02698811251360754\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Each incident of failure of a novel drug to translate from preclinical experiments into the clinic increases the pressure to justify the use of animals in these experiments and for the interpretation of findings to be valid and convincing. This is especially the case with research of psychedelics, because they have already been tested extensively in humans. One reason for failure to translate is that preclinical research findings and conclusions are rarely, if ever, confirmed independently. Another is an incautious interpretation of the validity of the animal models that are used, in respect of their relevance to the human disorder of interest and its treatment. This article discusses both these points in the context of preclinical investigations of psychedelics as fast-acting antidepressants, but the generic points are relevant to other human disorders as well.</p>\",\"PeriodicalId\":16892,\"journal\":{\"name\":\"Journal of Psychopharmacology\",\"volume\":\" \",\"pages\":\"2698811251360754\"},\"PeriodicalIF\":5.5000,\"publicationDate\":\"2025-08-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Psychopharmacology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/02698811251360754\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Psychopharmacology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/02698811251360754","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0

摘要

每一起新药从临床前实验转化为临床试验失败的事件都增加了在这些实验中使用动物的合理性以及对研究结果的有效和令人信服的解释的压力。迷幻药的研究尤其如此,因为它们已经在人类身上进行了广泛的测试。翻译失败的一个原因是,临床前研究结果和结论很少得到独立证实。另一个是对所使用的动物模型的有效性的不谨慎的解释,就它们与人类感兴趣的疾病及其治疗的相关性而言。这篇文章讨论了这两点在迷幻药作为速效抗抑郁药的临床前研究的背景下,但一般的点是相关的其他人类疾病以及。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Appraisal of the validity of preclinical investigations to predict the efficacy of psychedelic drugs as fast-acting antidepressants.

Each incident of failure of a novel drug to translate from preclinical experiments into the clinic increases the pressure to justify the use of animals in these experiments and for the interpretation of findings to be valid and convincing. This is especially the case with research of psychedelics, because they have already been tested extensively in humans. One reason for failure to translate is that preclinical research findings and conclusions are rarely, if ever, confirmed independently. Another is an incautious interpretation of the validity of the animal models that are used, in respect of their relevance to the human disorder of interest and its treatment. This article discusses both these points in the context of preclinical investigations of psychedelics as fast-acting antidepressants, but the generic points are relevant to other human disorders as well.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Journal of Psychopharmacology
Journal of Psychopharmacology 医学-精神病学
CiteScore
8.60
自引率
4.90%
发文量
126
审稿时长
3-8 weeks
期刊介绍: The Journal of Psychopharmacology is a fully peer-reviewed, international journal that publishes original research and review articles on preclinical and clinical aspects of psychopharmacology. The journal provides an essential forum for researchers and practicing clinicians on the effects of drugs on animal and human behavior, and the mechanisms underlying these effects. The Journal of Psychopharmacology is truly international in scope and readership.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信