去氨加压素口服冻干剂治疗原发性单症状性夜间遗尿症患儿复发的预测因素

IF 1.9 3区 医学 Q2 PEDIATRICS
Djordje Topalovic, Jelena Milin Lazovic, Branislav Trifunovic, Ivana Filipovic, Marko Jovic, Sladjana Mihajlovic, Sasa Milivojevic
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引用次数: 0

摘要

目的:评估儿童原发性单症状性夜间遗尿患者口服冻干去氨加压素后复发的预测因素。方法:2018 - 2025年进行前瞻性队列研究。我们评估了患者的年龄和性别、依从性、停药方法和其他参数是否影响复发率。该研究纳入了168名被诊断为PMNE的儿童,其中94名复发,74名无复发。结果:与年龄较小的儿童相比,年龄大于7岁的患者更有可能保持无复发(56%比32.1%,p = 0.002)。与有组织的停药相比,立即停止治疗与复发显著相关(66.7% vs 33.3%, p = 0.005)。药物给药后液体摄入量与复发之间存在显著关联(61.6%比38.4%,p = 0.037)。缺乏对饮食指导的遵守与复发显著相关(62.9%比37.1%,p = 0.034)。复发患者的日间功能性膀胱容量(FDBC)显著降低(p = 0.002)。多变量分析确定了两个独立的预测因素:年龄小于7岁和突然停药是PMNE患者复发的危险因素。结论:患者年龄小于7岁和突然停药是口服去氨加压素治疗原发性单症状性夜间遗尿患者复发的两个重要危险因素。药物使用后的液体摄入和不遵守饮食建议也会影响复发的发生,但它们不是独立的因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Predictive factors for relapse in pediatric patients with primary monosymptomatic nocturnal enuresis treated with the desmopressin oral lyophilisate.

Objectives: To assess the predictive factors for relapse in pediatric patients with primary monosymptomatic nocturnal enuresis following the use desmopressin oral lyophilisate.

Methods: A prospective cohort study was conducted from 2018 to 2025. We evaluated whether patient age and gender, compliance, method of therapy discontinuation, and other parameters affected relapse occurrence. The study included 168 children diagnosed with PMNE, comprising 94 with relapse and 74 without relapse.

Results: Patients older than seven years were significantly more likely to remain relapse-free compared to younger children (56 % vs. 32.1 %, p = 0.002). Immediate cessation of therapy was significantly associated with relapse compared to structured withdrawal (66.7 % vs. 33.3 %, p = 0.005). A significant association was found between fluid intake after drug administration and relapse (61.6 % vs. 38.4 %, p = 0.037). A lack of adherence to dietary instructions was significantly associated with relapse (62.9 % vs. 37.1 %, p = 0.034). Functional daytime bladder capacity (FDBC) was significantly lower in patients who experienced relapse (p = 0.002). Multivariate analysis identified two independent predictors: age younger than seven years and abrupt therapy withdrawal as risk factors for relapse in PMNE patients.

Conclusions: Patient age under seven years and abrupt therapy withdrawal are two strong risk factors associated with relapse in patients using desmopressin oral lyophilisate for primary monosymptomatic nocturnal enuresis. Fluid intake after medication use and non-compliance with dietary recommendations also influence relapse occurrence, but they do not act as independent factors.

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来源期刊
Journal of Pediatric Urology
Journal of Pediatric Urology PEDIATRICS-UROLOGY & NEPHROLOGY
CiteScore
3.70
自引率
15.00%
发文量
330
审稿时长
4-8 weeks
期刊介绍: The Journal of Pediatric Urology publishes submitted research and clinical articles relating to Pediatric Urology which have been accepted after adequate peer review. It publishes regular articles that have been submitted after invitation, that cover the curriculum of Pediatric Urology, and enable trainee surgeons to attain theoretical competence of the sub-specialty. It publishes regular reviews of pediatric urological articles appearing in other journals. It publishes invited review articles by recognised experts on modern or controversial aspects of the sub-specialty. It enables any affiliated society to advertise society events or information in the journal without charge and will publish abstracts of papers to be read at society meetings.
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