预发芽糙米提取物和γ-谷米醇对高果糖/高脂肪饮食诱导的非酒精性脂肪性肝病和心脏并发症的疗效比较

IF 1.1 4区 医学 Q4 NUTRITION & DIETETICS
Bin-Nan Wu, Hui-Li Lin, Huey-Jen Su, Pei-Wen Cheng, Ya-Mei Chen, Chi-Long Hao, Kuo-Ping Shen
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引用次数: 0

摘要

本动物实验旨在评价发芽糙米(EP)提取物和γ-谷米醇(γ-oryzanol)对非酒精性脂肪性肝病(NAFLD)及其相关心脏并发症的疗效。用高果糖水(HFW)和高脂肪饲料(HFD)诱导WKY大鼠NAFLD 4周。另外两组小鼠分别饲喂HFW和HFD,同时每天口服EP 200 μL/kg或γ-谷维素2 mg/kg,连续4周。NAFLD被成功诱导,表现为体、肝和心脏重量明显增加,血压和心率增加,高甘油三酯血症,高尿酸血症,肝功能指数升高:谷丙转氨酶(GPT),血液中IL-6和TNF-α水平升高,肝脏中TG水平升高。NAFLD大鼠脂质合成、炎症、心肌纤维化和肥厚蛋白表达均发生不良变化。然而,当NAFLD大鼠同时喂食EP或γ-谷米醇时,包括谷草转氨酶(GOT)在内的不良饮食诱导效应的发展明显改善。EP可以降低尿酸水平,而γ-谷米醇则没有。EP和γ-谷米醇逆转了脂质合成、炎症、心脏纤维化和肥厚水平的增加。我们得出结论,EP有效地预防了HFW/ hfd诱导的NAFLD及其相关的心脏并发症,这可能是通过改善脂质稳态和抑制炎症来实现的。我们相信EP和γ-谷米醇一样,可以作为预防和控制NAFLD及相关心功能障碍的有益药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of the Efficacy of Pre-Germinated Brown Rice Extract and γ-Oryzanol against Non-Alcoholic Fatty Liver Disease and Cardiac Complications Induced by a High-Fructose/Fat Diet.

This animal experiment aimed to evaluate the efficacy of the extract of pre-germinated brown rice (EP) and γ-oryzanol on non-alcoholic fatty liver disease (NAFLD) and the cardiac complications associated with it. WKY rats were fed high-fructose water (HFW) and high-fat diet (HFD) for 4 wk to induce NAFLD. The other two groups were fed HFW and HFD, while oral administration of EP 200 μL/kg or γ-oryzanol 2 mg/kg every day for 4 wk. NAFLD was successfully induced in as evidenced by clear increases in body, hepatic and cardiac weight as well as by increases in blood pressure and heart rate, hypertriglyceridemia, hyperuricemia, higher liver function index: glutamic pyruvic transaminase (GPT), higher levels of IL-6 and TNF-α in the blood and higher levels TG in the liver. NAFLD rats also had adverse changes the protein expressions of lipid synthesis, inflammation, cardiac fibrosis and hypertrophy. However, when the NAFLD rats were simultaneously fed EP or γ-oryzanol, the development of adverse diet-induced effects, including glutamic oxaloacetic transaminase (GOT), were clearly ameliorated. Specifically, EP could reduce uric acid levels, while γ-oryzanol did not. EP, as well as γ-oryzanol, reversed the increases in levels of lipid synthesis, inflammation, cardiac fibrosis and hypertrophy. We concluded that EP effectively prevented HFW/HFD-induced NAFLD and its associated cardiac complications, which it likely achieved through an improvement of lipid homeostasis and inhibition of inflammation. We believe that EP, like γ-oryzanol, can be developed as a beneficial agent for the prevention and control of NAFLD and associated cardiac dysfunction.

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来源期刊
CiteScore
1.80
自引率
6.20%
发文量
63
审稿时长
6-12 weeks
期刊介绍: The Journal of Nutritional Science and Vitaminology is an international medium publishing in English of original work in all branches of nutritional science, food science and vitaminology from any country. Manuscripts submitted for publication should be as concise as possible and must be based on the results of original research or of original interpretation of existing knowledge not previously published. Although data may have been reported, in part, in preliminary or abstract form, a full report of such research is unacceptable if it has been or will be submitted for consideration by another journal.
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