Dongje Lee, Hang-Rai Kim, Yu Jeong Park, Yisuh Ahn, Daeho Lee, Jungyeun Lee, Su Jin Chung, Seung Yeon Kim, Yeji Hwang, Ji Young Yun, Jin Whan Cho, Kyum-Yil Kwon, Seong-Beom Koh, Sung Hoon Kang
{"title":"数字认知训练治疗帕金森病伴轻度认知障碍的可行性及初步疗效：一项初步研究。","authors":"Dongje Lee, Hang-Rai Kim, Yu Jeong Park, Yisuh Ahn, Daeho Lee, Jungyeun Lee, Su Jin Chung, Seung Yeon Kim, Yeji Hwang, Ji Young Yun, Jin Whan Cho, Kyum-Yil Kwon, Seong-Beom Koh, Sung Hoon Kang","doi":"10.14802/jmd.25135","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Cognitive impairment is common in Parkinson's disease (PD), with few pharmacological options. We evaluated the effects of a digital cognitive training program (SUPERBRAIN), previously effective in Alzheimer's risk populations, on cognitive function in PD.</p><p><strong>Methods: </strong>Twenty-nine patients with PD and mild cognitive impairment (PD-MCI) from four clinics were randomized to intervention (n=16) or control (n=7). The intervention group completed a 12-week, home-based, tablet cognitive training program (25-30 min/day, 7 days/week). Cognitive outcomes were assessed using the Seoul Neuropsychological Screening Battery pre- and post-intervention.</p><p><strong>Results: </strong>Adherence was 79.4%. The intervention group showed significant improvements in the Seoul Verbal Learning Test (SVLT) delayed recall and controlled oral word association test, with no changes in controls. ANCOVA confirmed a greater SVLT improvement in the intervention group ((F-statistics = 7.15, P-value = 0.015, partial η² = 0.28).</p><p><strong>Conclusions: </strong>SUPERBRAIN is feasible and improves cognitive function in PD-MCI.</p>","PeriodicalId":16372,"journal":{"name":"Journal of Movement Disorders","volume":" ","pages":""},"PeriodicalIF":2.8000,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Feasibility and Preliminary Efficacy of Digital Cognitive Training in Parkinson's Disease with Mild Cognitive Impairment: A Pilot Study.\",\"authors\":\"Dongje Lee, Hang-Rai Kim, Yu Jeong Park, Yisuh Ahn, Daeho Lee, Jungyeun Lee, Su Jin Chung, Seung Yeon Kim, Yeji Hwang, Ji Young Yun, Jin Whan Cho, Kyum-Yil Kwon, Seong-Beom Koh, Sung Hoon Kang\",\"doi\":\"10.14802/jmd.25135\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Cognitive impairment is common in Parkinson's disease (PD), with few pharmacological options. We evaluated the effects of a digital cognitive training program (SUPERBRAIN), previously effective in Alzheimer's risk populations, on cognitive function in PD.</p><p><strong>Methods: </strong>Twenty-nine patients with PD and mild cognitive impairment (PD-MCI) from four clinics were randomized to intervention (n=16) or control (n=7). The intervention group completed a 12-week, home-based, tablet cognitive training program (25-30 min/day, 7 days/week). Cognitive outcomes were assessed using the Seoul Neuropsychological Screening Battery pre- and post-intervention.</p><p><strong>Results: </strong>Adherence was 79.4%. The intervention group showed significant improvements in the Seoul Verbal Learning Test (SVLT) delayed recall and controlled oral word association test, with no changes in controls. ANCOVA confirmed a greater SVLT improvement in the intervention group ((F-statistics = 7.15, P-value = 0.015, partial η² = 0.28).</p><p><strong>Conclusions: </strong>SUPERBRAIN is feasible and improves cognitive function in PD-MCI.</p>\",\"PeriodicalId\":16372,\"journal\":{\"name\":\"Journal of Movement Disorders\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2025-08-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Movement Disorders\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.14802/jmd.25135\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Movement Disorders","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.14802/jmd.25135","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Feasibility and Preliminary Efficacy of Digital Cognitive Training in Parkinson's Disease with Mild Cognitive Impairment: A Pilot Study.
Objective: Cognitive impairment is common in Parkinson's disease (PD), with few pharmacological options. We evaluated the effects of a digital cognitive training program (SUPERBRAIN), previously effective in Alzheimer's risk populations, on cognitive function in PD.
Methods: Twenty-nine patients with PD and mild cognitive impairment (PD-MCI) from four clinics were randomized to intervention (n=16) or control (n=7). The intervention group completed a 12-week, home-based, tablet cognitive training program (25-30 min/day, 7 days/week). Cognitive outcomes were assessed using the Seoul Neuropsychological Screening Battery pre- and post-intervention.
Results: Adherence was 79.4%. The intervention group showed significant improvements in the Seoul Verbal Learning Test (SVLT) delayed recall and controlled oral word association test, with no changes in controls. ANCOVA confirmed a greater SVLT improvement in the intervention group ((F-statistics = 7.15, P-value = 0.015, partial η² = 0.28).
Conclusions: SUPERBRAIN is feasible and improves cognitive function in PD-MCI.
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