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引用次数: 0
摘要
背景：评价雷公藤多苷对子宫内膜异位症（EMs）的治疗效果及其对血清性激素水平、肿瘤标志物和炎症因子（血清CA125、CA199、雌二醇、FSH、IL-6、TNF-a）的影响。方法：将108例患者随机分为对照组、黄体酮组和雷公藤苷组，每组治疗3个月。比较治疗前后两组患者的临床疗效及血清雌二醇、促卵泡激素、肿瘤标志物（肿瘤抗原125、肿瘤抗原199）、促炎因子水平。结果：雷公雷公苷组临床有效率明显高于对照组（90.74% vs 75.93%），雌二醇、促卵泡激素、肿瘤抗原125、肿瘤抗原199、IL-6、TNF-a、HSCRP水平明显低于对照组。结论：雷公藤多苷治疗EMS患者临床疗效显著，可显著提高血清性激素水平，降低肿瘤标志物水平，减轻炎症反应，毒副作用最小。
Serum CA125, CA199, estradiol, FSH, IL-6, TNF-a in endometriosis after administration of Tripterygium wilfordii glycosides.
Background: To evaluate the therapeutic effects of Tripterygium wilfordii glycosides on endometriosis (EMs) and their effects on serum sex hormone levels, tumour markers, and inflammatory factors (serum CA125, CA199, Estradiol, FSH, IL-6, TNF-a).
Methods: A total of 108 patients were randomly divided into control, progesterone, and Tripterygium wilfordii glycoside-treated groups, each receiving treatment for three months. The clinical efficacy and serum levels of estradiol, follicle-stimulating hormone, tumour markers (cancer antigen125 and cancer antigen199), and pro-inflammatory cytokines were compared before and after treatment.
Results: The Tripterygium wilfordii glycoside group exhibited a significantly higher clinically effective rate (90.74% versus 75.93%) and more significant reductions in estradiol, follicle-stimulating hormone, cancer antigen125, cancer antigen199, IL-6, TNF-a, and HSCRP levels than the control group.
Conclusions: Tripterygium glycosides exhibit significant clinical efficacy in treating patients with EMS by significantly improving serum sex hormone levels, reducing tumour marker levels, alleviating inflammatory reactions, and exerting minimal toxic side effects.
期刊介绍：
The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly.
The Journal publishes original scientific and specialized articles on all aspects of
clinical and medical biochemistry,
molecular medicine,
clinical hematology and coagulation,
clinical immunology and autoimmunity,
clinical microbiology,
virology,
clinical genomics and molecular biology,
genetic epidemiology,
drug measurement,
evaluation of diagnostic markers,
new reagents and laboratory equipment,
reference materials and methods,
reference values,
laboratory organization,
automation,
quality control,
clinical metrology,
all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.
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