{"title":"饱和多延迟肾动脉自旋标记技术在5t MR：与3t的比较研究。","authors":"Xinyu Tong, Chen Chen, Zihan Ning, Rui Shen, Ne Yang, Shuheng Zhang, Shuo Chen, Zuo-Xiang He, Xihai Zhao","doi":"10.1002/jmri.70079","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The feasibility of renal multi-delay arterial spin labeling (ASL) imaging at 5 T remains unclear.</p><p><strong>Purpose: </strong>To evaluate the feasibility of the saturated multi-delay renal ASL (SAMURAI) sequence at 5 T by comparing image quality and perfusion quantification with 3 T.</p><p><strong>Study type: </strong>Prospective, cross-sectional.</p><p><strong>Population: </strong>Twenty healthy volunteers (28.6 ± 7.8 years, 9 males) for primary comparison; 6 volunteers (24.2 ± 1.5 years, 5 males) for reproducibility study at 5 T.</p><p><strong>Field strength/sequence: </strong>SAMURAI sequence at 3 T and 5 T.</p><p><strong>Assessment: </strong>The SAMURAI sequence was optimized at 5 T with renal-specific B1 shimming and an optimized saturation scheme by numerical simulation. Each participant underwent 3 T and 5 T scans in randomized order. Cortical T1 value, renal blood flow (RBF), arterial and tissue bolus arrival times were measured. The signal-to-noise ratio (SNR) and cortico-medullary contrast-to-noise ratio (CNR) were calculated from perfusion-weighted images. Short-term repeatability (n = 20) and reproducibility (n = 6) tests of quantitative parameters were performed at 5 T.</p><p><strong>Statistical tests: </strong>Differences and agreement between 3 T and 5 T were analyzed using the Wilcoxon signed-rank test, intraclass correlation coefficients (ICC) and linear correlation analysis (R<sup>2</sup>). The repeatability at 5 T was assessed by ICC. A p < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>Renal cortical T1 values were significantly higher at 5 T than 3 T (1417.9 ± 75.7 ms vs. 1184.2 ± 84.4 ms), with R<sup>2</sup> = 0.509. Cortical RBF showed an insignificant difference between 5 T and 3 T: 324.4 (interquartile range [IQR]: 310.1-366.4) vs. 329.7 (IQR: 309.5-368.1) [mL/100 g/min] (p = 0.333), with R<sup>2</sup> = 0.914. 5 T showed significantly higher mean SNR (4.6 vs. 3.9) and CNR (3.2 vs. 2.0) than 3 T across all inversion times, with excellent repeatability and reproducibility of quantitative parameters (ICC = 0.855-0.973).</p><p><strong>Data conclusions: </strong>Renal quantitative imaging with SAMURAI sequence at 5 T is feasible and repeatable, with significantly higher SNR and CNR than 3 T and strong interfield agreement of cortical RBF measurements.</p><p><strong>Level of evidence: 2: </strong></p><p><strong>Technical efficacy stage: </strong>1.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.5000,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Saturated Multi-Delay Renal Arterial Spin Labeling Technique at 5 T MR: A Comparative Study With 3 T.\",\"authors\":\"Xinyu Tong, Chen Chen, Zihan Ning, Rui Shen, Ne Yang, Shuheng Zhang, Shuo Chen, Zuo-Xiang He, Xihai Zhao\",\"doi\":\"10.1002/jmri.70079\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The feasibility of renal multi-delay arterial spin labeling (ASL) imaging at 5 T remains unclear.</p><p><strong>Purpose: </strong>To evaluate the feasibility of the saturated multi-delay renal ASL (SAMURAI) sequence at 5 T by comparing image quality and perfusion quantification with 3 T.</p><p><strong>Study type: </strong>Prospective, cross-sectional.</p><p><strong>Population: </strong>Twenty healthy volunteers (28.6 ± 7.8 years, 9 males) for primary comparison; 6 volunteers (24.2 ± 1.5 years, 5 males) for reproducibility study at 5 T.</p><p><strong>Field strength/sequence: </strong>SAMURAI sequence at 3 T and 5 T.</p><p><strong>Assessment: </strong>The SAMURAI sequence was optimized at 5 T with renal-specific B1 shimming and an optimized saturation scheme by numerical simulation. Each participant underwent 3 T and 5 T scans in randomized order. Cortical T1 value, renal blood flow (RBF), arterial and tissue bolus arrival times were measured. The signal-to-noise ratio (SNR) and cortico-medullary contrast-to-noise ratio (CNR) were calculated from perfusion-weighted images. Short-term repeatability (n = 20) and reproducibility (n = 6) tests of quantitative parameters were performed at 5 T.</p><p><strong>Statistical tests: </strong>Differences and agreement between 3 T and 5 T were analyzed using the Wilcoxon signed-rank test, intraclass correlation coefficients (ICC) and linear correlation analysis (R<sup>2</sup>). The repeatability at 5 T was assessed by ICC. A p < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>Renal cortical T1 values were significantly higher at 5 T than 3 T (1417.9 ± 75.7 ms vs. 1184.2 ± 84.4 ms), with R<sup>2</sup> = 0.509. Cortical RBF showed an insignificant difference between 5 T and 3 T: 324.4 (interquartile range [IQR]: 310.1-366.4) vs. 329.7 (IQR: 309.5-368.1) [mL/100 g/min] (p = 0.333), with R<sup>2</sup> = 0.914. 5 T showed significantly higher mean SNR (4.6 vs. 3.9) and CNR (3.2 vs. 2.0) than 3 T across all inversion times, with excellent repeatability and reproducibility of quantitative parameters (ICC = 0.855-0.973).</p><p><strong>Data conclusions: </strong>Renal quantitative imaging with SAMURAI sequence at 5 T is feasible and repeatable, with significantly higher SNR and CNR than 3 T and strong interfield agreement of cortical RBF measurements.</p><p><strong>Level of evidence: 2: </strong></p><p><strong>Technical efficacy stage: </strong>1.</p>\",\"PeriodicalId\":16140,\"journal\":{\"name\":\"Journal of Magnetic Resonance Imaging\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2025-08-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Magnetic Resonance Imaging\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/jmri.70079\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Magnetic Resonance Imaging","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/jmri.70079","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Saturated Multi-Delay Renal Arterial Spin Labeling Technique at 5 T MR: A Comparative Study With 3 T.
Background: The feasibility of renal multi-delay arterial spin labeling (ASL) imaging at 5 T remains unclear.
Purpose: To evaluate the feasibility of the saturated multi-delay renal ASL (SAMURAI) sequence at 5 T by comparing image quality and perfusion quantification with 3 T.
Study type: Prospective, cross-sectional.
Population: Twenty healthy volunteers (28.6 ± 7.8 years, 9 males) for primary comparison; 6 volunteers (24.2 ± 1.5 years, 5 males) for reproducibility study at 5 T.
Field strength/sequence: SAMURAI sequence at 3 T and 5 T.
Assessment: The SAMURAI sequence was optimized at 5 T with renal-specific B1 shimming and an optimized saturation scheme by numerical simulation. Each participant underwent 3 T and 5 T scans in randomized order. Cortical T1 value, renal blood flow (RBF), arterial and tissue bolus arrival times were measured. The signal-to-noise ratio (SNR) and cortico-medullary contrast-to-noise ratio (CNR) were calculated from perfusion-weighted images. Short-term repeatability (n = 20) and reproducibility (n = 6) tests of quantitative parameters were performed at 5 T.
Statistical tests: Differences and agreement between 3 T and 5 T were analyzed using the Wilcoxon signed-rank test, intraclass correlation coefficients (ICC) and linear correlation analysis (R2). The repeatability at 5 T was assessed by ICC. A p < 0.05 was considered statistically significant.
Results: Renal cortical T1 values were significantly higher at 5 T than 3 T (1417.9 ± 75.7 ms vs. 1184.2 ± 84.4 ms), with R2 = 0.509. Cortical RBF showed an insignificant difference between 5 T and 3 T: 324.4 (interquartile range [IQR]: 310.1-366.4) vs. 329.7 (IQR: 309.5-368.1) [mL/100 g/min] (p = 0.333), with R2 = 0.914. 5 T showed significantly higher mean SNR (4.6 vs. 3.9) and CNR (3.2 vs. 2.0) than 3 T across all inversion times, with excellent repeatability and reproducibility of quantitative parameters (ICC = 0.855-0.973).
Data conclusions: Renal quantitative imaging with SAMURAI sequence at 5 T is feasible and repeatable, with significantly higher SNR and CNR than 3 T and strong interfield agreement of cortical RBF measurements.
期刊介绍：
The Journal of Magnetic Resonance Imaging (JMRI) is an international journal devoted to the timely publication of basic and clinical research, educational and review articles, and other information related to the diagnostic applications of magnetic resonance.
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