Zidong Yang, Fanhua Guo, Steve Mendoza, Ziyang Huang, Yingying Li, Yunqing Ying, Xin Cheng, Qi Yang, Yonggang Shi, Danny J J Wang
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The differences in VDI were assessed between CADASIL and control groups. The relationships between changes in VDI and cognitive performance and disease burden were studied in the CADASIL group.</p><p><strong>Statistical tests: </strong>Two-tailed independent samples t-tests were employed to assess the difference in VDI between CADASIL and control groups. Generalized linear mixed-effect models were used to assess the associations of VDI with cognitive performance and disease burden. Voxel-wise analyses were performed to further explore the associations of regional VDI with cognitive performance and disease burden after FDR correction.</p><p><strong>Results: </strong>Reduced mean VDI was found in gray matter of CADASIL patients (1.31 ± 0.06) compared to controls (1.35 ± 0.03), which was significantly associated with lower MoCA scores (β = 52.89, SE = 12.99, 95% CI [26.38, 79.40]), and higher cerebral small vessel disease (cSVD) burden scores (β = -14.34, SE = 3.22, 95% CI [-20.91, -7.76]) in CADASIL patients. Voxel-wise analyses revealed reduced regional VDI in regions of the temporal pole, insula, cingulate cortex, and orbitofrontal cortex in CADASIL patients.</p><p><strong>Data conclusion: </strong>The VDI technique based on high-resolution black-blood MRI demonstrated changes in regional VDI in CADASIL patients and offers a noninvasive imaging tool to advance the understanding of the mechanisms underlying cSVD.</p><p><strong>Evidence level: </strong>3.</p><p><strong>Technical efficiency: </strong>Stage 2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":" ","pages":""},"PeriodicalIF":3.5000,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12462767/pdf/","citationCount":"0","resultStr":"{\"title\":\"Assessment of Small Vessel Density Changes in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalophy (CADASIL) by High-Resolution Black-Blood MRI.\",\"authors\":\"Zidong Yang, Fanhua Guo, Steve Mendoza, Ziyang Huang, Yingying Li, Yunqing Ying, Xin Cheng, Qi Yang, Yonggang Shi, Danny J J Wang\",\"doi\":\"10.1002/jmri.70096\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Direct assessments of cerebral small vessels in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) remain a challenge.</p><p><strong>Purpose: </strong>To investigate changes of cerebral small vessels in CADASIL using iso-0.5 mm black-blood MRI.</p><p><strong>Study type: </strong>Case control study.</p><p><strong>Population: </strong>Thirty-six genetically confirmed CADASIL patients (23 female, 43 ± 12.48 years) and 35 matched healthy controls (27 female, 40 ± 11.57 years).</p><p><strong>Field strength/sequence: </strong>3T using a T1-weighted turbo spin-echo with variable flip angles sequence.</p><p><strong>Assessment: </strong>Vessel density images (VDIs) were derived from black-blood MRI by using a semi-automatic pipeline with a Jerman filter. The differences in VDI were assessed between CADASIL and control groups. The relationships between changes in VDI and cognitive performance and disease burden were studied in the CADASIL group.</p><p><strong>Statistical tests: </strong>Two-tailed independent samples t-tests were employed to assess the difference in VDI between CADASIL and control groups. Generalized linear mixed-effect models were used to assess the associations of VDI with cognitive performance and disease burden. Voxel-wise analyses were performed to further explore the associations of regional VDI with cognitive performance and disease burden after FDR correction.</p><p><strong>Results: </strong>Reduced mean VDI was found in gray matter of CADASIL patients (1.31 ± 0.06) compared to controls (1.35 ± 0.03), which was significantly associated with lower MoCA scores (β = 52.89, SE = 12.99, 95% CI [26.38, 79.40]), and higher cerebral small vessel disease (cSVD) burden scores (β = -14.34, SE = 3.22, 95% CI [-20.91, -7.76]) in CADASIL patients. 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引用次数: 0
摘要
背景：直接评估脑常染色体显性动脉病变伴皮质下梗死和脑白质病（CADASIL）的脑小血管仍然是一个挑战。目的：应用iso-0.5 mm黑血MRI观察CADASIL患者脑小血管的变化。研究类型：病例对照研究。人群：36例遗传确诊的CADASIL患者（23例女性，43±12.48岁）和35例匹配的健康对照（27例女性，40±11.57岁）。场强/序列：3T使用t1加权涡轮自旋回波与可变翻转角度序列。评估：血管密度图像（VDIs）由黑血MRI通过半自动管道与杰曼滤波器获得。评估CADASIL组和对照组之间VDI的差异。研究CADASIL组VDI变化与认知能力和疾病负担的关系。统计学检验：采用双尾独立样本t检验评价CADASIL组与对照组VDI的差异。使用广义线性混合效应模型来评估VDI与认知能力和疾病负担的关系。进行体素分析，进一步探讨FDR校正后区域VDI与认知表现和疾病负担的关系。结果：与对照组（1.35±0.03）相比，CADASIL患者灰质平均VDI降低（1.31±0.06），这与CADASIL患者MoCA评分较低（β = 52.89, SE = 12.99, 95% CI[26.38, 79.40]）和脑血管病（cSVD）负担评分较高（β = -14.34, SE = 3.22, 95% CI[-20.91, -7.76]）显著相关。体素分析显示，CADASIL患者的颞极、脑岛、扣带皮层和眶额皮质区域VDI降低。数据结论：基于高分辨率黑血MRI的VDI技术显示了CADASIL患者局部VDI的变化，并提供了一种非侵入性成像工具，以促进对cSVD潜在机制的理解。证据等级：3。技术效率：第二阶段。
Assessment of Small Vessel Density Changes in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalophy (CADASIL) by High-Resolution Black-Blood MRI.
Background: Direct assessments of cerebral small vessels in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) remain a challenge.
Purpose: To investigate changes of cerebral small vessels in CADASIL using iso-0.5 mm black-blood MRI.
Field strength/sequence: 3T using a T1-weighted turbo spin-echo with variable flip angles sequence.
Assessment: Vessel density images (VDIs) were derived from black-blood MRI by using a semi-automatic pipeline with a Jerman filter. The differences in VDI were assessed between CADASIL and control groups. The relationships between changes in VDI and cognitive performance and disease burden were studied in the CADASIL group.
Statistical tests: Two-tailed independent samples t-tests were employed to assess the difference in VDI between CADASIL and control groups. Generalized linear mixed-effect models were used to assess the associations of VDI with cognitive performance and disease burden. Voxel-wise analyses were performed to further explore the associations of regional VDI with cognitive performance and disease burden after FDR correction.
Results: Reduced mean VDI was found in gray matter of CADASIL patients (1.31 ± 0.06) compared to controls (1.35 ± 0.03), which was significantly associated with lower MoCA scores (β = 52.89, SE = 12.99, 95% CI [26.38, 79.40]), and higher cerebral small vessel disease (cSVD) burden scores (β = -14.34, SE = 3.22, 95% CI [-20.91, -7.76]) in CADASIL patients. Voxel-wise analyses revealed reduced regional VDI in regions of the temporal pole, insula, cingulate cortex, and orbitofrontal cortex in CADASIL patients.
Data conclusion: The VDI technique based on high-resolution black-blood MRI demonstrated changes in regional VDI in CADASIL patients and offers a noninvasive imaging tool to advance the understanding of the mechanisms underlying cSVD.
期刊介绍：
The Journal of Magnetic Resonance Imaging (JMRI) is an international journal devoted to the timely publication of basic and clinical research, educational and review articles, and other information related to the diagnostic applications of magnetic resonance.
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