{"title":"虾青素通过修复肠道屏障、调节特定肠道菌群和减少炎症细胞浸润来减轻葡聚糖硫酸钠诱导的小鼠结肠炎。","authors":"Guangzhe Shen, Du Yu, Longfei Xu, Tiezheng Yang","doi":"10.1155/jimr/3381950","DOIUrl":null,"url":null,"abstract":"<p><p>As a dietary supplement for humans and animals, Astaxanthin (Ax) is widely believed to possess antioxidant and anti-inflammatory properties. In this study, we attempted to evaluate the protective effects of Ax on dextran sodium sulfate (DSS)-induced colitis in mice and the underlying molecular mechanism. Our results suggested that Ax significantly reduced the severity of DSS-induced colitis in mice, as evidenced by increased colon length, decreased disease activity index (DAI), and attenuated inflammatory factors. In addition, Ax significantly increased the diversity of gut microbiota in mice with colitis, remodeled the microbial composition, promoted the production of beneficial bacteria (e.g., Lactobacillaceae), and inhibited the production of harmful bacteria (e.g., Lachnospiraceae and Muribaculaceae). In conclusion, Ax alleviated DSS-induced colitis by maintaining the intestinal barrier and regulating intestinal microbes.</p>","PeriodicalId":15952,"journal":{"name":"Journal of Immunology Research","volume":"2025 ","pages":"3381950"},"PeriodicalIF":3.6000,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12393947/pdf/","citationCount":"0","resultStr":"{\"title\":\"Astaxanthin Mitigates Dextran Sulfate Sodium-Induced Colitis in Mice by Repairing the Intestinal Barrier, Regulating Specific Intestinal Flora, and Reducing Inflammatory Cell Infiltration.\",\"authors\":\"Guangzhe Shen, Du Yu, Longfei Xu, Tiezheng Yang\",\"doi\":\"10.1155/jimr/3381950\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>As a dietary supplement for humans and animals, Astaxanthin (Ax) is widely believed to possess antioxidant and anti-inflammatory properties. In this study, we attempted to evaluate the protective effects of Ax on dextran sodium sulfate (DSS)-induced colitis in mice and the underlying molecular mechanism. Our results suggested that Ax significantly reduced the severity of DSS-induced colitis in mice, as evidenced by increased colon length, decreased disease activity index (DAI), and attenuated inflammatory factors. In addition, Ax significantly increased the diversity of gut microbiota in mice with colitis, remodeled the microbial composition, promoted the production of beneficial bacteria (e.g., Lactobacillaceae), and inhibited the production of harmful bacteria (e.g., Lachnospiraceae and Muribaculaceae). In conclusion, Ax alleviated DSS-induced colitis by maintaining the intestinal barrier and regulating intestinal microbes.</p>\",\"PeriodicalId\":15952,\"journal\":{\"name\":\"Journal of Immunology Research\",\"volume\":\"2025 \",\"pages\":\"3381950\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2025-08-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12393947/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Immunology Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1155/jimr/3381950\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Immunology Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1155/jimr/3381950","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
Astaxanthin Mitigates Dextran Sulfate Sodium-Induced Colitis in Mice by Repairing the Intestinal Barrier, Regulating Specific Intestinal Flora, and Reducing Inflammatory Cell Infiltration.
As a dietary supplement for humans and animals, Astaxanthin (Ax) is widely believed to possess antioxidant and anti-inflammatory properties. In this study, we attempted to evaluate the protective effects of Ax on dextran sodium sulfate (DSS)-induced colitis in mice and the underlying molecular mechanism. Our results suggested that Ax significantly reduced the severity of DSS-induced colitis in mice, as evidenced by increased colon length, decreased disease activity index (DAI), and attenuated inflammatory factors. In addition, Ax significantly increased the diversity of gut microbiota in mice with colitis, remodeled the microbial composition, promoted the production of beneficial bacteria (e.g., Lactobacillaceae), and inhibited the production of harmful bacteria (e.g., Lachnospiraceae and Muribaculaceae). In conclusion, Ax alleviated DSS-induced colitis by maintaining the intestinal barrier and regulating intestinal microbes.
期刊介绍:
Journal of Immunology Research is a peer-reviewed, Open Access journal that provides a platform for scientists and clinicians working in different areas of immunology and therapy. The journal publishes research articles, review articles, as well as clinical studies related to classical immunology, molecular immunology, clinical immunology, cancer immunology, transplantation immunology, immune pathology, immunodeficiency, autoimmune diseases, immune disorders, and immunotherapy.