中心经验与循环死亡心脏移植术后捐赠后更高的生存率相关

IF 6 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Brian E Woolley, Yeahwa Hong, Umar Nasim, Nidhi Iyanna, Ander Dorken-Gallastegi, Samantha N Machinski, Gavin W Hickey, Mary E Keebler, Edward T Horn, David J Kaczorowski
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引用次数: 0

摘要

背景:较高的中心容积与实体器官移植预后的改善有关。然而,中心经验对循环死亡(DCD)心脏移植后捐赠结果的影响尚不清楚。本研究评估累积DCD中心经验与DCD移植后存活之间的关系。方法:查询UNOS注册表中2019年1月1日至2023年12月31日接受DCD心脏移植的成人受者。根据累积的DCD中心经验将受者分为低(≤10)、中(11-24)和高(≥25)移植容量中心。主要终点为移植后1年生存率。采用限制性三次样条(RCS)模型评估体积与预后的关系。结果:59个中心共纳入1114名DCD心脏移植受者。当控制与脑死亡后捐赠(DBD)中心容量和中心水平DBD移植后生存率无关的混杂因素(89.0% vs 92.9%, p=0.025)时,与高容量中心相比,低累积DCD容量与移植后1年DCD生存率较低相关。RCS显示,移植后1年死亡率随着DCD容量的增加而下降,最多可达20例DCD,超过这一数字,生存增长趋于平稳。在所有中心容量类别中,与直接获取和灌注(DPP)相比,常温区域灌注(NRP)与相似的生存率相关。结论:较高的DCD中心累积经验与移植后1年DCD生存率相关,与DBD中心容量或性能无关。在累积约20例DCD病例后,生存率趋于稳定。这些发现强调了DCD特定机构经验的重要性,并支持将DCD心脏移植扩展到更多中心,同时保持良好的结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Center experience is associated with greater survival following donation after circulatory death heart transplantation.

Background: Higher center volume has been associated with improved outcomes in solid organ transplantation. However, the impact of center experience on donation after circulatory death (DCD) heart transplantation outcomes remains unclear. This study evaluates the association between cumulative DCD center experience and DCD post-transplant survival.

Methods: The United Network for Organ Sharing registry was queried for adult recipients who underwent DCD heart transplantation from January 1, 2019 to December 31, 2023. Recipients were stratified by cumulative DCD center experience into low (≤10), intermediate (11-24), and high (≥25) transplant volume centers. The primary outcome was 1-year post-transplant survival. A restricted cubic spline (RCS) model was used to assess the volume-outcome relationship.

Results: A total of 1,114 DCD heart transplant recipients across 59 centers were included. Low cumulative DCD volume was associated with lower 1-year DCD post-transplant survival compared to high-volume centers when controlling for confounders (89.0% vs 92.9%, p = 0.025), independent of donation after brain death (DBD) center volume and center-level DBD post-transplant survival. RCS showed decreasing 1-year post-transplant mortality with increasing DCD volume up to 20 DCD cases, beyond which survival gains plateaued. Normothermic regional perfusion was associated with similar survival compared to direct procurement and perfusion across all center volume categories.

Conclusions: Higher cumulative DCD center experience is associated with improved 1-year DCD post-transplant survival independent of DBD center volume or performance. Survival gains plateau after approximately 20 cumulative DCD cases. These findings highlight the importance of DCD-specific institutional experience and support the expansion of DCD heart transplantation to more centers while maintaining favorable outcomes.

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来源期刊
CiteScore
10.10
自引率
6.70%
发文量
1667
审稿时长
69 days
期刊介绍: The Journal of Heart and Lung Transplantation, the official publication of the International Society for Heart and Lung Transplantation, brings readers essential scholarly and timely information in the field of cardio-pulmonary transplantation, mechanical and biological support of the failing heart, advanced lung disease (including pulmonary vascular disease) and cell replacement therapy. Importantly, the journal also serves as a medium of communication of pre-clinical sciences in all these rapidly expanding areas.
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