Harnessing nanotechnology for enhanced wound healing: integrating polymeric nanoparticles with rosuvastatin for targeted therapy.

Purpose: This study investigates the development and evaluation of rosuvastatin-loaded polymeric nanoparticles as a targeted wound-healing therapy. The work aims to overcome solubility and bioavailability limitations and to enhance therapeutic outcomes in cutaneous wound repair.

Methods: Six nanoparticle formulations were prepared via the nanoprecipitation method, varying polymer type and excipient content. Particle size, polydispersity index and zeta potential were measured by dynamic light scattering, while drug-loading efficiency was determined spectrophotometrically. In vitro release study was assessed. A gel incorporated optimised formulation was evaluated in a rat excisional wound model. Wound-area reduction and healing percentages were quantified over 14 days.

Results: The PVP-K90-based formulation exhibited the smallest mean diameter, narrow size distribution and high entrapment efficiency. In vitro, this system achieved higher cumulative rosuvastatin release at 24 h. In vivo, the rosuvastatin hydrogel accelerated the wound-healing cascade, achieving complete closure by day 14, with significantly greater re-epithelialisation and neovascularisation compared to controls (p < .001).

Conclusions: The findings demonstrate that polymeric nanoprecipitation offers a versatile platform to tailor nanoparticle characteristics and release profiles, translating into marked improvements in wound repair. This approach holds promise for the clinical translation of statin-based nanoformulations in both acute and chronic wound management.