评价牙科光生物调节镇痛作用的挑战：述评。

IF 5.5 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of dentistry Pub Date : 2025-08-30 DOI:10.1016/j.jdent.2025.106077

Jessica Joanna Zachar, Peter Reher, Sobia Zafar, Laurence James Walsh

{"title":"评价牙科光生物调节镇痛作用的挑战：述评。","authors":"Jessica Joanna Zachar, Peter Reher, Sobia Zafar, Laurence James Walsh","doi":"10.1016/j.jdent.2025.106077","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><div>The purpose of this narrative review is to explore the challenges and limitations in the methodologies for evaluating the analgesic effects of photobiomodulation in dentistry.</div></div><div><h3>Study selection, data & sources</h3><div>The literature published up to April 2025 in the English language was sourced from online databases and reference lists; search engines included Medline, PubMed, Embase, Scopus, and Google Scholar; the relevance of papers was discussed by two reviewers; and a total of 42 publications were included in this narrative review. If there was disagreement between the two reviewers, a third one moderated the selection process.</div></div><div><h3>Conclusions</h3><div>Photobiomodulation has emerged as an alternative to traditional pharmacological analgesia in dentistry. Both lasers and light-emitting diodes can be used to modulate cellular responses, showing promising results for pain reduction in the oral cavity, particularly in the dental pulp and mucosal soft tissues. However, evaluating analgesic effects remains challenging due to variations in light sources, parameters, delivery modes, and target sites. Additionally, inconsistencies in study methodologies such as pain assessments, placebo effects, pain conditioning, and the presence of non-responders further complicate interpretation. Other variables, such as differences between hard and soft tissues, also contribute to variability.</div></div><div><h3>Clinical Significance</h3><div>Photobiomodulation (PBM) shows promising potential as a non-invasive analgesic approach in dentistry. However, its integration into clinical practice remains uncertain due to variability in study methodologies, inconsistent reporting of treatment parameters, and a lack of standardized outcome measures. Consequently, the clinical significance of PBM results can vary widely, ranging from meaningful analgesic effects in some studies to minimal or non-significant effects in others. The absence of standardized PBM guidelines in dentistry continues to be a major barrier to its consistent implementation.</div></div>","PeriodicalId":15585,"journal":{"name":"Journal of dentistry","volume":"162 ","pages":"Article 106077"},"PeriodicalIF":5.5000,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Challenges in evaluating the analgesic effects of photobiomodulation in dentistry: A narrative review\",\"authors\":\"Jessica Joanna Zachar, Peter Reher, Sobia Zafar, Laurence James Walsh\",\"doi\":\"10.1016/j.jdent.2025.106077\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objectives</h3><div>The purpose of this narrative review is to explore the challenges and limitations in the methodologies for evaluating the analgesic effects of photobiomodulation in dentistry.</div></div><div><h3>Study selection, data & sources</h3><div>The literature published up to April 2025 in the English language was sourced from online databases and reference lists; search engines included Medline, PubMed, Embase, Scopus, and Google Scholar; the relevance of papers was discussed by two reviewers; and a total of 42 publications were included in this narrative review. If there was disagreement between the two reviewers, a third one moderated the selection process.</div></div><div><h3>Conclusions</h3><div>Photobiomodulation has emerged as an alternative to traditional pharmacological analgesia in dentistry. Both lasers and light-emitting diodes can be used to modulate cellular responses, showing promising results for pain reduction in the oral cavity, particularly in the dental pulp and mucosal soft tissues. However, evaluating analgesic effects remains challenging due to variations in light sources, parameters, delivery modes, and target sites. Additionally, inconsistencies in study methodologies such as pain assessments, placebo effects, pain conditioning, and the presence of non-responders further complicate interpretation. Other variables, such as differences between hard and soft tissues, also contribute to variability.</div></div><div><h3>Clinical Significance</h3><div>Photobiomodulation (PBM) shows promising potential as a non-invasive analgesic approach in dentistry. However, its integration into clinical practice remains uncertain due to variability in study methodologies, inconsistent reporting of treatment parameters, and a lack of standardized outcome measures. Consequently, the clinical significance of PBM results can vary widely, ranging from meaningful analgesic effects in some studies to minimal or non-significant effects in others. The absence of standardized PBM guidelines in dentistry continues to be a major barrier to its consistent implementation.</div></div>\",\"PeriodicalId\":15585,\"journal\":{\"name\":\"Journal of dentistry\",\"volume\":\"162 \",\"pages\":\"Article 106077\"},\"PeriodicalIF\":5.5000,\"publicationDate\":\"2025-08-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of dentistry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0300571225005238\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of dentistry","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0300571225005238","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}

引用次数: 0

摘要

目的：这篇叙述性综述的目的是探讨在评估牙科光生物调节镇痛作用的方法中的挑战和局限性。研究选择、数据和来源：截至2025年4月发表的英文文献来源于在线数据库和参考文献列表；搜索引擎包括Medline、PubMed、Embase、Scopus和谷歌Scholar；论文的相关性由两位审稿人讨论；本综述共收录42篇文献。如果两位审稿人之间有分歧，第三位审稿人会缓和选择过程。结论：光生物调节已成为传统牙科药物镇痛的替代方法。激光和发光二极管都可以用来调节细胞反应，显示出有希望的结果，减轻口腔疼痛，特别是在牙髓和粘膜软组织。然而，由于光源、参数、给药方式和靶点的变化，评估镇痛效果仍然具有挑战性。此外，研究方法的不一致性，如疼痛评估、安慰剂效应、疼痛调节和无反应者的存在，进一步使解释复杂化。其他变量，如硬组织和软组织之间的差异，也有助于变异性。临床意义：光生物调节（PBM）作为一种无创的牙科镇痛方法，具有广阔的应用前景。然而，由于研究方法的可变性、治疗参数的不一致报告以及缺乏标准化的结果测量，其与临床实践的结合仍然不确定。因此，PBM结果的临床意义差异很大，从一些研究中有意义的镇痛作用到其他研究中最小或无显著作用。缺乏标准化的牙科PBM指南仍然是其一致实施的主要障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Challenges in evaluating the analgesic effects of photobiomodulation in dentistry: A narrative review

Objectives

The purpose of this narrative review is to explore the challenges and limitations in the methodologies for evaluating the analgesic effects of photobiomodulation in dentistry.

Study selection, data & sources

The literature published up to April 2025 in the English language was sourced from online databases and reference lists; search engines included Medline, PubMed, Embase, Scopus, and Google Scholar; the relevance of papers was discussed by two reviewers; and a total of 42 publications were included in this narrative review. If there was disagreement between the two reviewers, a third one moderated the selection process.

Conclusions

Photobiomodulation has emerged as an alternative to traditional pharmacological analgesia in dentistry. Both lasers and light-emitting diodes can be used to modulate cellular responses, showing promising results for pain reduction in the oral cavity, particularly in the dental pulp and mucosal soft tissues. However, evaluating analgesic effects remains challenging due to variations in light sources, parameters, delivery modes, and target sites. Additionally, inconsistencies in study methodologies such as pain assessments, placebo effects, pain conditioning, and the presence of non-responders further complicate interpretation. Other variables, such as differences between hard and soft tissues, also contribute to variability.

Clinical Significance

Photobiomodulation (PBM) shows promising potential as a non-invasive analgesic approach in dentistry. However, its integration into clinical practice remains uncertain due to variability in study methodologies, inconsistent reporting of treatment parameters, and a lack of standardized outcome measures. Consequently, the clinical significance of PBM results can vary widely, ranging from meaningful analgesic effects in some studies to minimal or non-significant effects in others. The absence of standardized PBM guidelines in dentistry continues to be a major barrier to its consistent implementation.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of dentistry 医学-牙科与口腔外科

CiteScore

7.30

自引率

11.40%

发文量

349

审稿时长

35 days

期刊介绍： The Journal of Dentistry has an open access mirror journal The Journal of Dentistry: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. The Journal of Dentistry is the leading international dental journal within the field of Restorative Dentistry. Placing an emphasis on publishing novel and high-quality research papers, the Journal aims to influence the practice of dentistry at clinician, research, industry and policy-maker level on an international basis. Topics covered include the management of dental disease, periodontology, endodontology, operative dentistry, fixed and removable prosthodontics, dental biomaterials science, long-term clinical trials including epidemiology and oral health, technology transfer of new scientific instrumentation or procedures, as well as clinically relevant oral biology and translational research. The Journal of Dentistry will publish original scientific research papers including short communications. It is also interested in publishing review articles and leaders in themed areas which will be linked to new scientific research. Conference proceedings are also welcome and expressions of interest should be communicated to the Editor.