Charlène A Mauger, Bharath Ambale-Venkatesh, Avan Suinesiaputra, David A Bluemke, Colin O Wu, Joao A C Lima, Alistair A Young
{"title":"多民族动脉粥样硬化研究中左心室心肌重构的纵向轨迹与心血管危险因素的关联","authors":"Charlène A Mauger, Bharath Ambale-Venkatesh, Avan Suinesiaputra, David A Bluemke, Colin O Wu, Joao A C Lima, Alistair A Young","doi":"10.1016/j.jocmr.2025.101943","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Understanding the influence of cardiovascular risk factors on longitudinal cardiac remodelling requires three-dimensional analysis of longitudinal shape changes beyond scalar indicators such as mass and volumes. The aim of this study is to determine trajectories of cardiovascular risk factor-related remodelling in a large cohort imaging study.</p><p><strong>Methods: </strong>We examined 2,521 participants (54% female, aged 60±9y) of the Multi-Ethnic Study of Atherosclerosis (MESA) at baseline and after 10 years. Myocardial remodelling was assessed by longitudinal left ventricular shape trajectories derived from cardiac magnetic resonance imaging using a statistical shape atlas. Penalized logistic regression was used to examine the associations between trajectory scores and cardiovascular risk factors, after adjustment for sex and age at baseline. Multivariate regression was used to determine independent shape changes associated with each risk factor.</p><p><strong>Results: </strong>Between baseline and follow-up, there was a higher prevalence of hypertension (18.4%), antihypertensive medication usage (21.6%), statin usage, and treated diabetes mellitus (8.9%); all p < 0.05. Longitudinal shape trajectory scores had stronger associations with obesity, high blood pressure, hypertension medication and diabetes mellitus, than mass and volume changes (p<0.05). Multivariate regression showed independent longitudinal changes in wall thickening with obesity (13% increase), smoking (11% decrease), and high systolic blood pressure (5.6% increase), with distinct regional variations.</p><p><strong>Conclusions: </strong>Trajectories of cardiovascular risk factor-related longitudinal remodelling can be examined using shape atlases. In addition to global changes, each risk factor is associated with a distinct regional remodelling of the myocardium.</p>","PeriodicalId":15221,"journal":{"name":"Journal of Cardiovascular Magnetic Resonance","volume":" ","pages":"101943"},"PeriodicalIF":6.1000,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Longitudinal Trajectories of Left Ventricular Myocardial Remodelling: Associations with Cardiovascular Risk Factors in the Multi-Ethnic Study of Atherosclerosis.\",\"authors\":\"Charlène A Mauger, Bharath Ambale-Venkatesh, Avan Suinesiaputra, David A Bluemke, Colin O Wu, Joao A C Lima, Alistair A Young\",\"doi\":\"10.1016/j.jocmr.2025.101943\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Understanding the influence of cardiovascular risk factors on longitudinal cardiac remodelling requires three-dimensional analysis of longitudinal shape changes beyond scalar indicators such as mass and volumes. The aim of this study is to determine trajectories of cardiovascular risk factor-related remodelling in a large cohort imaging study.</p><p><strong>Methods: </strong>We examined 2,521 participants (54% female, aged 60±9y) of the Multi-Ethnic Study of Atherosclerosis (MESA) at baseline and after 10 years. Myocardial remodelling was assessed by longitudinal left ventricular shape trajectories derived from cardiac magnetic resonance imaging using a statistical shape atlas. Penalized logistic regression was used to examine the associations between trajectory scores and cardiovascular risk factors, after adjustment for sex and age at baseline. Multivariate regression was used to determine independent shape changes associated with each risk factor.</p><p><strong>Results: </strong>Between baseline and follow-up, there was a higher prevalence of hypertension (18.4%), antihypertensive medication usage (21.6%), statin usage, and treated diabetes mellitus (8.9%); all p < 0.05. Longitudinal shape trajectory scores had stronger associations with obesity, high blood pressure, hypertension medication and diabetes mellitus, than mass and volume changes (p<0.05). Multivariate regression showed independent longitudinal changes in wall thickening with obesity (13% increase), smoking (11% decrease), and high systolic blood pressure (5.6% increase), with distinct regional variations.</p><p><strong>Conclusions: </strong>Trajectories of cardiovascular risk factor-related longitudinal remodelling can be examined using shape atlases. In addition to global changes, each risk factor is associated with a distinct regional remodelling of the myocardium.</p>\",\"PeriodicalId\":15221,\"journal\":{\"name\":\"Journal of Cardiovascular Magnetic Resonance\",\"volume\":\" \",\"pages\":\"101943\"},\"PeriodicalIF\":6.1000,\"publicationDate\":\"2025-08-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Cardiovascular Magnetic Resonance\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.jocmr.2025.101943\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cardiovascular Magnetic Resonance","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jocmr.2025.101943","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Longitudinal Trajectories of Left Ventricular Myocardial Remodelling: Associations with Cardiovascular Risk Factors in the Multi-Ethnic Study of Atherosclerosis.
Background: Understanding the influence of cardiovascular risk factors on longitudinal cardiac remodelling requires three-dimensional analysis of longitudinal shape changes beyond scalar indicators such as mass and volumes. The aim of this study is to determine trajectories of cardiovascular risk factor-related remodelling in a large cohort imaging study.
Methods: We examined 2,521 participants (54% female, aged 60±9y) of the Multi-Ethnic Study of Atherosclerosis (MESA) at baseline and after 10 years. Myocardial remodelling was assessed by longitudinal left ventricular shape trajectories derived from cardiac magnetic resonance imaging using a statistical shape atlas. Penalized logistic regression was used to examine the associations between trajectory scores and cardiovascular risk factors, after adjustment for sex and age at baseline. Multivariate regression was used to determine independent shape changes associated with each risk factor.
Results: Between baseline and follow-up, there was a higher prevalence of hypertension (18.4%), antihypertensive medication usage (21.6%), statin usage, and treated diabetes mellitus (8.9%); all p < 0.05. Longitudinal shape trajectory scores had stronger associations with obesity, high blood pressure, hypertension medication and diabetes mellitus, than mass and volume changes (p<0.05). Multivariate regression showed independent longitudinal changes in wall thickening with obesity (13% increase), smoking (11% decrease), and high systolic blood pressure (5.6% increase), with distinct regional variations.
Conclusions: Trajectories of cardiovascular risk factor-related longitudinal remodelling can be examined using shape atlases. In addition to global changes, each risk factor is associated with a distinct regional remodelling of the myocardium.
期刊介绍:
Journal of Cardiovascular Magnetic Resonance (JCMR) publishes high-quality articles on all aspects of basic, translational and clinical research on the design, development, manufacture, and evaluation of cardiovascular magnetic resonance (CMR) methods applied to the cardiovascular system. Topical areas include, but are not limited to:
New applications of magnetic resonance to improve the diagnostic strategies, risk stratification, characterization and management of diseases affecting the cardiovascular system.
New methods to enhance or accelerate image acquisition and data analysis.
Results of multicenter, or larger single-center studies that provide insight into the utility of CMR.
Basic biological perceptions derived by CMR methods.