苦味受体作为治疗靶点:苦中药在支气管哮喘中的作用及最新进展综述。

IF 1.3 4区 医学 Q3 ALLERGY
Xinru Zhang, Jiaqi Ma, Anan Zhang, Jinmei Zhang, Lixia Wu, Fang Wang, Dandan Hu
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引用次数: 0

摘要

目的:综述味觉受体2型(TAS2Rs)作为支气管哮喘潜在治疗靶点的研究进展,重点研究苦味中药生物活性物质的调控作用,为哮喘防治提供新的策略。方法:通过PubMed检索相关研究,包括体外实验、动物模型和临床观察。本文对苦中药衍生化合物如生物碱、黄酮类化合物和萜类化合物激活TAS2Rs的文献进行了分析,强调其机制与气道平滑肌(ASM)松弛、抗炎反应和免疫调节有关。结果:TAS2Rs在呼吸道广泛表达。它们的激活诱导ASM松弛,抑制炎症因子释放,调节免疫反应。苦苷A、黄芩苷、柚皮苷和青蒿琥酯等苦味化合物可作为TAS2R激动剂,改善气道高反应性和炎症。黄芩苷等成分也可以在基因转录水平调控TAS2R的表达。结论:TAS2Rs调控关键的呼吸过程,为治疗哮喘和其他呼吸系统疾病提供了新的靶点。苦味中药生物活性化合物通过激活TAS2Rs具有抗炎和支气管扩张作用,具有临床应用前景。然而,大部分相关研究仍处于基础研究阶段,临床证据不足。今后应开展大规模的临床试验和进一步的机理研究,以促进苦中药治疗哮喘的现代化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Bitter taste receptors as therapeutic targets: a review of the role and recent advances of bitter traditional Chinese medicine in bronchial asthma.

Objective: This review explores recent advances in taste receptors type 2 (TAS2Rs) as potential therapeutic targets for bronchial asthma, focusing on the regulatory effects of bioactive compounds from bitter traditional Chinese medicines to provide new strategies for asthma prevention and treatment.

Methods: Relevant studies were identified through PubMed, including in vitro experiments, animal models, and clinical observations. Literature on the activation of TAS2Rs by bitter traditional Chinese medicine-derived compounds such as alkaloids, flavonoids, and terpenoids was analyzed, emphasizing mechanisms involving airway smooth muscle (ASM) relaxation, anti-inflammatory responses, and immune modulation.

Results: TAS2Rs are widely expressed in the respiratory tract. Their activation induces ASM relaxation, inhibits inflammatory factor release, and modulates immune responses. Bitter compounds like kudinoside A, baicalin, naringin, and artesunate act as TAS2R agonists, improving airway hyperresponsiveness and inflammation. Some components, such as baicalin, can also regulate TAS2R expression at the gene transcription level.

Conclusions: TAS2Rs regulate key respiratory processes, offering a new target for treating asthma and other respiratory diseases. Bitter traditional Chinese medicine bioactive compounds show anti-inflammatory and bronchodilatory effects by activating TAS2Rs, showing clinical promise. However, most of the related research is still in the basic research stage, and clinical evidence remains insufficient. Future efforts should focus on large-scale clinical trials and further mechanistic studies to promote the modernization of bitter traditional Chinese medicine in asthma treatment.

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来源期刊
Journal of Asthma
Journal of Asthma 医学-过敏
CiteScore
4.00
自引率
5.30%
发文量
158
审稿时长
3-8 weeks
期刊介绍: Providing an authoritative open forum on asthma and related conditions, Journal of Asthma publishes clinical research around such topics as asthma management, critical and long-term care, preventative measures, environmental counselling, and patient education.
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