早产儿视网膜病变的预后营养指数:疾病严重程度的潜在指标?

IF 1.4 4区 医学 Q3 OPHTHALMOLOGY
Ahmet Ozdemir, Abdulcemal Gurpinar, Zeynep Yuksel, Canan Seren, Ozlem Eski Yucel
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引用次数: 0

摘要

目的:评价预后营养指数(PNI)在预测疾病严重程度和早产儿视网膜病变(ROP)治疗需求中的作用。方法:回顾性队列研究纳入406例早产儿。病例分为无ROP组(1组)、ROP自行消退组(2组)、ROP需治疗组(3组)。从医疗记录中获得患者的临床和人口统计数据,包括胎龄(GA)、出生体重(BW)、血清白蛋白水平和PNI值。采用Logistic回归确定严重ROP的预测因素,采用受试者工作特征(ROC)分析确定PNI对ROP治疗要求的判别能力。结果:各组GA、BW差异有统计学意义(p = 0.001)。2、3组血清白蛋白水平、淋巴细胞和血小板计数、PNI值均低于1组(p = 0.001)。在有序回归分析中,GA (OR = 0.750, p = 0.001)和PNI (OR = 0.787, p = 0.001)与严重ROP呈显著负相关。ROC分析显示,PNI (AUC = 0.822, p = 0.001)预测ROP治疗需求的最佳临界值为34.02,灵敏度为78.2%,特异性为75.5%,预测能力最高。结论:PNI与ROP的严重程度及治疗需求有显著相关性。该结果支持营养和免疫状态与ROP之间的关系。将PNI与GA、BW等临床参数相结合,对ROP的预后和治疗需求的早期判断非常有用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prognostic nutritional index in retinopathy of prematurity: a potential indicator of disease severity?

Purpose: To evaluate the role of the Prognostic Nutritional Index (PNI) in predicting disease severity and the need for treatment of retinopathy of prematurity (ROP).

Methods: This retrospective cohort study included 406 preterm infants. The cases were divided into three groups: without ROP (group 1), with spontaneously regressed ROP (group 2), and with ROP requiring treatment (group 3). Patients' clinical and demographic data, including gestational age (GA), birth weight (BW), serum albumin levels, and PNI values, were obtained from medical records. Logistic regression was performed to identify predictors of severe ROP, and receiver operating characteristic (ROC) analysis was conducted to determine the discriminative power of PNI for the treatment requirement of ROP.

Results: GA and BW differed in all groups (p = 0.001). Serum albumin level, lymphocyte and platelet counts, and PNI values were lower in groups 2 and 3 than in group 1 (p = 0.001). In ordinal regression analysis, GA (OR = 0.750, p = 0.001) and PNI (OR = 0.787, p = 0.001) showed a significant and inverse association with severe ROP. ROC analysis showed that PNI (AUC = 0.822, p = 0.001) had the highest predictive power at the optimum cut-off value of 34.02 with 78.2% sensitivity and 75.5% specificity for predicting the treatment requirement of ROP.

Conclusion: PNI is significantly associated with the severity of ROP and treatment requirements. This result supports the relationship between nutritional and immune status and ROP. Considering PNI with clinical parameters, such as GA and BW, will be very useful for the early determination of prognosis and treatment needs in ROP.

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来源期刊
CiteScore
3.20
自引率
0.00%
发文量
451
期刊介绍: International Ophthalmology provides the clinician with articles on all the relevant subspecialties of ophthalmology, with a broad international scope. The emphasis is on presentation of the latest clinical research in the field. In addition, the journal includes regular sections devoted to new developments in technologies, products, and techniques.
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