癌症相关成纤维细胞代谢重编程在肿瘤发生和进展中的作用(综述)。

IF 4.9 3区 医学 Q1 ONCOLOGY
International journal of oncology Pub Date : 2025-11-01 Epub Date: 2025-08-29 DOI:10.3892/ijo.2025.5796
Ruyue Li, Yintao Li
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引用次数: 0

摘要

肿瘤的发生发展受肿瘤细胞自身及肿瘤微环境(tumor microenvironment, TME)各组成部分的影响。其中,主要基质成分癌相关成纤维细胞(cancer - associated fibroblasts, CAFs)可分化为不同类型的细胞,在TME中发挥重要作用。本文综述了cas代谢重编程在肿瘤发生发展中的作用。由于肿瘤的快速生长是一个与能量供应密不可分的过程,而TME具有缺氧和营养缺乏的特点,代谢重编程可以逆转能量供应不足对TME的影响。研究发现,CAFs可以通过改变代谢模式影响肿瘤的增殖、迁移、侵袭、转移和耐药。本综述促进了对CAFs代谢重编程的研究,并强调了考虑CAFs在TME中的异质性和可塑性的重要性,这将导致开发针对CAFs特定代谢途径的更有效的治疗策略,从而有可能提高癌症治疗的疗效并克服耐药性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Role of metabolic reprogramming of cancer‑associated fibroblasts in tumor development and progression (Review).

Role of metabolic reprogramming of cancer‑associated fibroblasts in tumor development and progression (Review).

Role of metabolic reprogramming of cancer‑associated fibroblasts in tumor development and progression (Review).

Role of metabolic reprogramming of cancer‑associated fibroblasts in tumor development and progression (Review).

The occurrence and development of tumors is affected by tumor cells themselves and various components of the tumor microenvironment (TME). Among these, cancer‑associated fibroblasts (CAFs), the main stromal component, can differentiate from different cell types and play an important role in the TME. The present review summarized the role of the metabolic reprogramming of CAFs in tumor development and progression. As the rapid growth of tumors is a process inseparable from energy supply and the TME is characterized by hypoxia and nutrient deficiencies, metabolic reprogramming can reverse the effects of a lack of energy supply in the TME. Studies have found that CAFs can affect tumor proliferation, migration, invasion, metastasis and drug resistance by changing metabolic patterns. The present review promoted research on the metabolic reprogramming of CAFs and emphasized the importance of considering the heterogeneity and plasticity of CAFs in the TME, which will lead to the development of more effective therapeutic strategies that target specific metabolic pathways in CAFs, potentially improving the efficacy of cancer treatments and overcoming drug resistance.

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来源期刊
CiteScore
9.60
自引率
0.00%
发文量
157
审稿时长
2.1 months
期刊介绍: The main aim of Spandidos Publications is to facilitate scientific communication in a clear, concise and objective manner, while striving to provide prompt publication of original works of high quality. The journals largely concentrate on molecular and experimental medicine, oncology, clinical and experimental cancer treatment and biomedical research. All journals published by Spandidos Publications Ltd. maintain the highest standards of quality, and the members of their Editorial Boards are world-renowned scientists.
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