Lp - PLA2在癌症领域:从分子机制到治疗潜力(综述)。

IF 4.9 3区 医学 Q1 ONCOLOGY
International journal of oncology Pub Date : 2025-11-01 Epub Date: 2025-08-24 DOI:10.3892/ijo.2025.5793
Xiaorong Yang, Yongbo Tu, Na Liang, Lingli Li, Jian Zhang, Jingyu Xu, Chunming Li
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引用次数: 0

摘要

脂蛋白相关磷脂酶A2 (Lp - PLA2)是磷脂酶A2超家族的重要成员,最初因其在心血管疾病中的促炎作用而被研究。最近的研究揭示了它在肿瘤发生中的重要作用:根据不同的环境,它可以作为肿瘤启动子或肿瘤抑制子。本综述系统地概述了Lp‑PLA2促进癌症发病的双重机制。作为肿瘤启动子,它通过诱导上皮-间充质转化、谷胱甘肽过氧化物酶4介导的对铁凋亡的抗性和血管内皮生长因子依赖性血管生成来促进癌症进展;相反,作为肿瘤抑制因子,它通过抑制乳腺癌基因1突变癌症中的Wnt/β - catenin通路或促进细胞凋亡来抑制肿瘤生长。机制研究阐明了Lp - PLA2与Notch和HIF1α等关键致癌通路之间的相互作用,同时强调了受微环境影响的功能二分法。目前的证据支持微环境导向靶向策略的发展,以及Lp - PLA2作为预后生物标志物和治疗靶点的潜在价值。这些发现为理解Lp - PLA2的环境依赖性作用提供了理论框架,并可能指导创新治疗方法的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Lp‑PLA2 in the cancer landscape: From molecular mechanisms to therapeutic potential (Review).

Lp‑PLA2 in the cancer landscape: From molecular mechanisms to therapeutic potential (Review).

Lp‑PLA2 in the cancer landscape: From molecular mechanisms to therapeutic potential (Review).

Lp‑PLA2 in the cancer landscape: From molecular mechanisms to therapeutic potential (Review).

Lipoprotein‑associated phospholipase A2 (Lp‑PLA2), an important member of the phospholipase A2 superfamily, was originally investigated for its proinflammatory role in cardiovascular diseases. Recent studies have revealed its significant role in tumorigenesis: It can act as either a tumor promoter or a tumor suppressor depending on the context. The present review systematically outlined the dual mechanisms by which Lp‑PLA2 contributes to cancer pathogenesis. As a tumor promoter, it promotes cancer progression via the induction of epithelial‑mesenchymal transition, glutathione peroxidase 4‑mediated resistance to ferroptosis, and vascular endothelial growth factor‑-dependent angiogenesis; conversely, as a tumor suppressor, it inhibits tumor growth by suppressing the Wnt/β‑catenin pathway in breast cancer gene 1‑mutated cancers or by promoting apoptosis. Mechanistic investigations clarify the interactions between Lp‑PLA2 and critical oncogenic pathways, such as the Notch and HIF1α pathways, while emphasizing the functional dichotomy that is influenced by the microenvironment. Current evidence supports the development of microenvironment‑guided targeting strategies and the potential value of Lp‑PLA2 as a prognostic biomarker and therapeutic target. These findings contribute to a theoretical framework for comprehending the context‑dependent roles of Lp‑PLA2 and may guide the development of innovative therapeutic approaches.

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来源期刊
CiteScore
9.60
自引率
0.00%
发文量
157
审稿时长
2.1 months
期刊介绍: The main aim of Spandidos Publications is to facilitate scientific communication in a clear, concise and objective manner, while striving to provide prompt publication of original works of high quality. The journals largely concentrate on molecular and experimental medicine, oncology, clinical and experimental cancer treatment and biomedical research. All journals published by Spandidos Publications Ltd. maintain the highest standards of quality, and the members of their Editorial Boards are world-renowned scientists.
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