IL-17RC多态性rs708567和rs76999397与急性淋巴细胞白血病的关系

IF 1.1 4区医学 Q3 GENETICS & HEREDITY

International Journal of Immunogenetics Pub Date : 2025-08-31 DOI:10.1111/iji.70012

Ali Aljuaimlani, Lamjed Mansour, Jameel Al-Tamimi, Jamilah Alshammari, Safa A Alqarzae, Fadwa M Alkhulaifi, Suliman Alomar

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引用次数: 0

摘要

背景：急性淋巴细胞白血病（ALL）的特点是骨髓或外周血中未成熟淋巴细胞前体的克隆性增殖。本研究调查了沙特人群中IL-17RC基因多态性是否与ALL风险增加有关。方法：本病例-对照研究纳入95例ALL患者和95例匹配对照。使用逻辑回归分析确定遗传多态性及其与ALL风险的关联。采用实时定量聚合酶链反应（qRT-PCR）检测IL-17RC mRNA表达水平。结果：rs76999397的GA和AA基因型携带者患ALL的风险显著增高（GA：优势比[OR] = 63.78, 95%可信区间[CI] = 25.51 ~ 159.43, p）。结论：rs76999397的GA和AA基因型与ALL风险增高有显著相关性，rs708567基因型与ALL风险增高无显著相关性。此外，CA和TA单倍型（rs708567/rs76999397）被发现与ALL易感性增加相关。

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The Association of IL-17RC Polymorphisms rs708567 and rs76999397 With Acute Lymphoblastic Leukaemia.

Background: Acute lymphoblastic leukaemia (ALL) is characterized by the clonal proliferation of immature lymphoid precursors in the bone marrow or peripheral blood. This study investigates whether genetic polymorphisms in IL-17RC are associated with an increased risk of ALL in the Saudi population.

Methods: This case-control study included 95 patients with ALL and 95 matched controls. Genetic polymorphisms and their associations with ALL risk were identified using logistic regression analysis. Additionally, quantitative real-time polymerase chain reaction (qRT-PCR) was used to assess the level of IL-17RC mRNA.

Results: The results revealed that carriers of the GA and AA genotypes of rs76999397 had a significantly increased risk of ALL (GA: odds ratios [OR] = 63.78, 95% confidence interval [CI] = 25.51-159.43, p < 0.0001; AA: OR = 18.22, 95% CI = 1.50-221.37, p < 0.0001). Additionally, we identified that an increased risk of ALL was associated with two haplotypes in IL-17RC, C-A and T-A (in the order of rs708567 and rs76999397) (OR = 46.73, 95% CI = 17.30-126.28; OR = 49.42, 95% CI = 6.95-351.45, respectively).

Conclusions: The results suggested that the GA and AA genotypes of rs76999397 were significantly associated with an increased risk of ALL, whereas rs708567 did not show a significant association. Furthermore, the CA and TA haplotypes (rs708567/rs76999397) were found to be associated with increased susceptibility to ALL.

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来源期刊

International Journal of Immunogenetics 医学-免疫学

CiteScore

4.70

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The International Journal of Immunogenetics (formerly European Journal of Immunogenetics) publishes original contributions on the genetic control of components of the immune system and their interactions in both humans and experimental animals. The term ''genetic'' is taken in its broadest sense to include studies at the evolutionary, molecular, chromosomal functional and population levels in both health and disease. Examples are: -studies of blood groups and other surface antigens- cell interactions and immune response- receptors, antibodies, complement components and cytokines- polymorphism- evolution of the organisation, control and function of immune system components- anthropology and disease associations- the genetics of immune-related disease: allergy, autoimmunity, immunodeficiency and other immune pathologies- All papers are seen by at least two independent referees and only papers of the highest quality are accepted.