从临床样本中分离的产β-内酰胺酶大肠杆菌的广谱横断面研究:印度尼西亚的单中心调查。

IF 3.2 Q3 MICROBIOLOGY
International Journal of Microbiology Pub Date : 2025-08-21 eCollection Date: 2025-01-01 DOI:10.1155/ijm/3743202
Fitrotin Azizah, Dita Artanti, Yety Eka Sispita Sari, Anindita Riesti Retno Arimurti, Arya Iswara, Afifah Khairunnisa, Muhammad Evy Prastiyanto, Daniel Geleta
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引用次数: 0

摘要

产生广谱β -内酰胺酶的大肠杆菌(esbl -产大肠杆菌)的出现是一个重大的公共卫生问题,特别是在印度尼西亚等发展中国家,那里关于这些耐药菌株的流行和特征的报告很少。这种数据的缺乏阻碍了有效的感染控制和抗生素管理工作。本研究旨在调查从印度尼西亚患者临床样本中分离的产esbl大肠杆菌的流行情况并评估其抗菌药物敏感性,从而有助于了解该地区的抗生素耐药模式。在印度尼西亚三宝垄RSUD Adhyatma医生医院进行了一项横断面研究,为期3年(从2022年1月至2024年12月)。从诊断为大肠杆菌感染的患者中获取临床标本,利用VITEK2 Compact系统对分离株进行鉴定和抗生素敏感性评估。数据通过费雪精确检验进行检验。在449株大肠杆菌中,199株(44.3%)被鉴定为ESBL,其中脓液(35.6%)和尿液(27.2%)患病率最高。产esbls的大肠杆菌分离株对阿莫西林-克拉维酸、头孢他啶、厄他培南、美罗培南和替加环素具有高敏感性(90%以上)。我们的研究还强调,与非ESBL相比,ESBL中多药耐药(MDR)的患病率更高。研究结果强调,迫切需要加强卫生保健机构的监测和感染控制措施,以对抗产生esbl的大肠杆菌的传播。医疗保健专业人员,包括护士和临床医生,必须意识到这种耐药模式,以指导经验性治疗选择,并改善由这些耐药菌株引起的感染的患者结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A Cross-Sectional Study of Extended-Spectrum <i>β</i>-Lactamase-Producing <i>Escherichia coli</i> Isolated From Clinical Samples: Single-Center Investigation in Indonesia.

A Cross-Sectional Study of Extended-Spectrum β-Lactamase-Producing Escherichia coli Isolated From Clinical Samples: Single-Center Investigation in Indonesia.

The emergence of extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-producing E. coli) is a significant public health concern, particularly in developing countries like Indonesia, where reports on the prevalence and characteristics of these resistant strains are scarce. This lack of data hampers effective infection control and antibiotic stewardship efforts. This study is aimed at investigating the prevalence and assessing the antimicrobial susceptibility profiles of ESBL-producing E. coli isolated from clinical samples of Indonesian patients, thereby contributing to an understanding of antibiotic resistance patterns in this region. A cross-sectional study was conducted at RSUD dr. Adhyatma Hospital, Semarang, Indonesia, over 3 years (from January 2022 to December 2024). Clinical specimens were obtained from patients diagnosed with E. coli infections, and isolates were identified and assessed for antibiotic susceptibility utilizing the VITEK2 Compact system. Data were examined via the Fisher's exact test. Out of 449 E. coli isolates, 199 (44.3%) were identified as ESBL, with the highest prevalence in pus (35.6%) and urine (27.2%). ESBL-producing E. coli isolates demonstrated high sensitivity (above 90%) to amoxicillin-clavulanic acid, ceftazidime, ertapenem, meropenem, and tigecycline. Our study also underlined the higher prevalence of multidrug resistance (MDR) in ESBL compared to non-ESBL. The results highlight the urgent need for enhanced surveillance and infection control measures in healthcare settings to combat the spread of ESBL-producing E. coli. Healthcare professionals, including nurses and clinicians, must be aware of this resistance pattern to guide empirical treatment choices and improve patient outcomes in managing infections caused by these resistant strains.

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来源期刊
CiteScore
7.90
自引率
0.00%
发文量
57
审稿时长
13 weeks
期刊介绍: International Journal of Microbiology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies on microorganisms and their interaction with hosts and the environment. The journal covers all microbes, including bacteria, fungi, viruses, archaea, and protozoa. Basic science will be considered, as well as medical and applied research.
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