恩格列净和肼嗪-硝酸异山梨酯联合治疗可改善黑人心力衰竭患者的预后。

IF 0.7 4区 医学 Q4 PHARMACOLOGY & PHARMACY
Padmamalini Baskaran, Mohammed Aldhaeefi, Anahita Asaadi, Morgan Jones, Emmanuel King, Dhakrit Rungkitwattanakul, La'Marcus Wingate
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引用次数: 0

摘要

背景:黑人患者伴射血分数降低(HFrEF)的心力衰竭发病率高得不成比例,血管扩张剂是关键的治疗策略。材料和方法:基于黑人HFrEF患者病历的回顾性队列研究,以及用恩帕列净(empa)和肼嗪-硝酸异山梨酯(H-ISDN)刺激小鼠胸主动脉的离体分析。结果:与单独使用H-ISDN相比,联合使用H-ISDN可协同激活体外胸主动脉中环鸟苷单磷酸(cGMP)的产生,改善HFrEF患者的肾功能,降低脑钠肽(BNP),降低死亡率。结论:Empa + H-ISDN可能通过降低氧化应激和提高一氧化氮(NO)的生物利用度,为黑人HFrEF患者提供了优越的益处。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Empagliflozin and hydralazine-isosorbide dinitrate combination therapy improves outcomes in black patients with heart failure.

Background: Black patients experience a disproportionately high incidence of heart failure with reduced ejection fraction (HFrEF), where vasodilators serve as a key therapeutic strategy.

Materials and methods: A retrospective cohort study based on medical records of Black patients with HFrEF and an ex vivo analysis of mouse thoracic aorta stimulated with empagliflozin (empa) and hydralazine-isosorbide dinitrate (H-ISDN).

Results: The combination synergistically activated cyclic guanosine monophosphate (cGMP) production in the ex vivo thoracic aorta and improved kidney function, reduced brain natriuretic peptide (BNP), and lowered mortality compared to H-ISDN alone in HFrEF patients.

Conclusion: Empa + H-ISDN offered superior benefits in Black patients with HFrEF, possibly by reducing oxidative stress and enhancing nitric oxide (NO) bioavailability.

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来源期刊
CiteScore
1.70
自引率
12.50%
发文量
116
审稿时长
4-8 weeks
期刊介绍: The International Journal of Clinical Pharmacology and Therapeutics appears monthly and publishes manuscripts containing original material with emphasis on the following topics: Clinical trials, Pharmacoepidemiology - Pharmacovigilance, Pharmacodynamics, Drug disposition and Pharmacokinetics, Quality assurance, Pharmacogenetics, Biotechnological drugs such as cytokines and recombinant antibiotics. Case reports on adverse reactions are also of interest.
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