评估脑卒中后单侧忽视的皮质兴奋性和功能网络:经颅磁刺激-脑电图调查(2024年10月)。

IF 5.2 2区 医学 Q2 ENGINEERING, BIOMEDICAL
Yichen Zhang;Linlin Ye;Wanying Zhao;Weiqun Song;Huanxin Xie;Lei Cao
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引用次数: 0

摘要

目的:单侧忽视(UN)是一种常见的脑卒中后疾病,但其潜在的病理机制尚未完全阐明。本研究旨在通过经颅磁刺激-脑电图(TMS-EEG)研究UN患者的皮质功能和脑网络连通性。方法:研究分为3组:10名健康对照,10名UN患者和10名非UN卒中患者。将经颅磁刺激应用于P4部位,记录并分析由此产生的脑电图反应。结果:UN患者在25 ~ 275 ms期间N100和皮质兴奋性振幅(CEA)有显著变化(p < 0.05)。时频分析进一步揭示了UN患者顶叶区theta波段活性的显著增加。源定位分析表明,在后期,神经信号传播主要局限于顶叶区域。时变脑电图网络分析显示,在早期阶段,UN患者表现出半球间额叶连通性增强,同时受影响的顶叶和对侧额叶之间的连通性减少。在后期阶段,观察到顶叶到枕叶的连通性显著下降,同时两个半球额叶和顶叶区域的连通性增加,表明大脑网络的广泛功能重组。结论:UN患者在受影响的顶叶皮层表现出皮层兴奋性减弱,同时伴有大脑网络连通性的改变和特定区域内连通性的增加。这些发现表明,大脑参与功能补偿和网络重组,以减轻中风引起的神经功能缺陷。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assessing Cortical Excitability and Functional Network in Post-Stroke Unilateral Neglect: A Transcranial Magnetic Stimulation- Electroencephalography Investigation
Objective: Unilateral neglect (UN) is a common post-stroke condition, yet its underlying pathological mechanisms are not fully elucidated. This study aims to explore cortical function and brain network connectivity in patients with UN by employing transcranial magnetic stimulation-electroencephalography (TMS-EEG).Methods: The study involved three groups: 10 healthy controls, 10 patients with UN, and 10 stroke patients without UN. TMS was applied to the P4 site, and the resulting EEG responses were recorded and analysed. Results: UN patients demonstrated significant alterations in the N100 (p <0.05) and cortical excitability amplitude (CEA) between 25–275 ms (p <0.05). Time-frequency analysis further revealed a marked increase in theta-band activity in the parietal region of UN patients. Source localisation analysis indicated that, in later stages, neural signal propagation was predominantly confined to the parietal region. Time-varying EEG network analysis revealed that, during the early stages, patients with UN exhibited enhanced interhemispheric frontal connectivity, coupled with a reduction in connectivity between the affected parietal lobe and the contralateral frontal lobe. In the later stages, a notable decrease in parieto-occipital connectivity was observed, alongside increased connectivity within the frontal and parietal regions of both hemispheres, suggesting a widespread functional reorganisation of brain networks. Conclusion: UN patients exhibit diminished cortical excitability in the affected parietal cortex, coupled with altered brain network connectivity and increases in connectivity within specific regions. These findings suggest that the brain engages in functional compensation and network reorganisation to mitigate the neurological deficits induced by stroke.
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来源期刊
CiteScore
8.60
自引率
8.20%
发文量
479
审稿时长
6-12 weeks
期刊介绍: Rehabilitative and neural aspects of biomedical engineering, including functional electrical stimulation, acoustic dynamics, human performance measurement and analysis, nerve stimulation, electromyography, motor control and stimulation; and hardware and software applications for rehabilitation engineering and assistive devices.
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