绘制沙特阿拉伯吉赞地区头虱种群的抗性突变图谱。

IF 2.9 3区医学 Q2 INFECTIOUS DISEASES

Infection and Drug Resistance Pub Date : 2025-08-20 eCollection Date: 2025-01-01 DOI:10.2147/IDR.S539626

Noha Talal Zelai

{"title":"绘制沙特阿拉伯吉赞地区头虱种群的抗性突变图谱。","authors":"Noha Talal Zelai","doi":"10.2147/IDR.S539626","DOIUrl":null,"url":null,"abstract":"Introduction: Pediculosis capitis remains a persistent public-health concern. Although pyrethroids are still the first-line treatment, their effectiveness is threatened by knock-down resistance (kdr), which arises from point mutations in the voltage-sensitive sodium channel (VSSC). This study aimed to assess the prevalence of kdr mutations in head lice populations across different regions of Jazan, Saudi Arabia.Methods: In this study, 59 head-louse specimens from multiple regions of Jazan were analyzed by PCR amplification and Sanger sequencing of a 908-bp fragment of the VSSC α-subunit gene.Results: The T917I mutation showed the highest allele frequency (0.38) and was concentrated in Jazan's southern and eastern border areas.Discussion: While overall kdr prevalence in Jazan is low, targeted surveillance is warranted in these regions, where resistance appears to be emerging.","PeriodicalId":13577,"journal":{"name":"Infection and Drug Resistance","volume":"18 ","pages":"4201-4206"},"PeriodicalIF":2.9000,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375342/pdf/","citationCount":"0","resultStr":"{\"title\":\"Mapping Knock-Down Resistance Mutations in Head-Louse Populations in Jazan, Saudi Arabia.\",\"authors\":\"Noha Talal Zelai\",\"doi\":\"10.2147/IDR.S539626\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction: Pediculosis capitis remains a persistent public-health concern. Although pyrethroids are still the first-line treatment, their effectiveness is threatened by knock-down resistance (kdr), which arises from point mutations in the voltage-sensitive sodium channel (VSSC). This study aimed to assess the prevalence of kdr mutations in head lice populations across different regions of Jazan, Saudi Arabia.Methods: In this study, 59 head-louse specimens from multiple regions of Jazan were analyzed by PCR amplification and Sanger sequencing of a 908-bp fragment of the VSSC α-subunit gene.Results: The T917I mutation showed the highest allele frequency (0.38) and was concentrated in Jazan's southern and eastern border areas.Discussion: While overall kdr prevalence in Jazan is low, targeted surveillance is warranted in these regions, where resistance appears to be emerging.\",\"PeriodicalId\":13577,\"journal\":{\"name\":\"Infection and Drug Resistance\",\"volume\":\"18 \",\"pages\":\"4201-4206\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2025-08-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375342/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Infection and Drug Resistance\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2147/IDR.S539626\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infection and Drug Resistance","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/IDR.S539626","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

摘要

头弓根病仍然是一个持续的公共卫生问题。尽管拟除虫菊酯仍然是一线治疗方法，但其有效性受到了由电压敏感钠通道（VSSC）点突变引起的敲除抗性（kdr）的威胁。本研究旨在评估沙特阿拉伯吉赞不同地区头虱种群中kdr突变的流行情况。方法：对来自吉赞省多个地区的59例头虱标本进行VSSC α-亚基基因908 bp片段的PCR扩增和Sanger测序分析。结果：T917I突变等位基因频率最高（0.38），集中在吉赞南部和东部边境地区。讨论：虽然吉赞的kdr总体流行率较低，但在这些似乎正在出现耐药性的地区，有必要进行有针对性的监测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Mapping Knock-Down Resistance Mutations in Head-Louse Populations in Jazan, Saudi Arabia.

查看原文本刊更多论文

Mapping Knock-Down Resistance Mutations in Head-Louse Populations in Jazan, Saudi Arabia.

Introduction: Pediculosis capitis remains a persistent public-health concern. Although pyrethroids are still the first-line treatment, their effectiveness is threatened by knock-down resistance (kdr), which arises from point mutations in the voltage-sensitive sodium channel (VSSC). This study aimed to assess the prevalence of kdr mutations in head lice populations across different regions of Jazan, Saudi Arabia.

Methods: In this study, 59 head-louse specimens from multiple regions of Jazan were analyzed by PCR amplification and Sanger sequencing of a 908-bp fragment of the VSSC α-subunit gene.

Results: The T917I mutation showed the highest allele frequency (0.38) and was concentrated in Jazan's southern and eastern border areas.

Discussion: While overall kdr prevalence in Jazan is low, targeted surveillance is warranted in these regions, where resistance appears to be emerging.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Infection and Drug Resistance Medicine-Pharmacology (medical)

CiteScore

5.60

自引率

7.70%

发文量

826

审稿时长

16 weeks

期刊介绍： About Journal Editors Peer Reviewers Articles Article Publishing Charges Aims and Scope Call For Papers ISSN: 1178-6973 Editor-in-Chief: Professor Suresh Antony An international, peer-reviewed, open access journal that focuses on the optimal treatment of infection (bacterial, fungal and viral) and the development and institution of preventative strategies to minimize the development and spread of resistance.