咖啡与肝细胞癌的风险:孟德尔随机化研究的系统回顾和荟萃分析。

IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Gut and Liver Pub Date : 2025-08-25 DOI:10.5009/gnl250227
Hyun Bin Choi, Hyuk Kim, Jeong-Ju Yoo, Sang Gyune Kim, Young-Seok Kim
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引用次数: 0

摘要

本系统综述和荟萃分析通过孟德尔随机化(MR)研究考察了咖啡摄入与肝细胞癌(HCC)风险之间的潜在因果关系。纳入了五项符合条件的MR研究,这些研究使用了分析方法,如逆方差加权(IVW)、MR- egger和加权中位数方法。虽然之前的观察性研究表明咖啡具有保护作用,但本研究中基于核磁共振的分析并没有证明所有方法之间存在统计学上显著的关联。IVW分析的优势比为0.92(95%可信区间为0.58 ~ 1.47),表明无显著影响。观察到中度至实质性异质性,但未发现发表偏倚。这些发现表明,由于观察性研究方法的局限性,先前报道的负相关可能被高估了。我们的研究结果强调了使用遗传信息方法推断因果关系的重要性,结果表明咖啡摄入可能不会降低HCC的风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Coffee and the Risk of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis of Mendelian Randomization Studies.

This systematic review and meta-analysis examined the potential causal link between coffee consumption and hepatocellular carcinoma (HCC) risk via Mendelian randomization (MR) studies. Five eligible MR studies that involved the use of analytical approaches such as inverse variance weighted (IVW), MR-Egger, and weighted median methods were included. While previous observational studies suggested a protective role of coffee, the MR-based analyses in this study did not demonstrate a statistically significant association across all methods. IVW analysis yielded an odds ratio of 0.92 (95% confidence interval, 0.58 to 1.47), indicating no significant effect. Moderate to substantial heterogeneity was observed, but no publication bias was detected. These findings suggest that the previously reported inverse association may have been overestimated due to methodological limitations in observational research. Our results emphasize the importance of using genetically informed methods to infer causality, and the results indicate that coffee consumption may not causally reduce the risk of HCC.

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来源期刊
Gut and Liver
Gut and Liver 医学-胃肠肝病学
CiteScore
7.50
自引率
8.80%
发文量
119
审稿时长
6-12 weeks
期刊介绍: Gut and Liver is an international journal of gastroenterology, focusing on the gastrointestinal tract, liver, biliary tree, pancreas, motility, and neurogastroenterology. Gut and Liver delivers up-to-date, authoritative papers on both clinical and research-based topics in gastroenterology. The Journal publishes original articles, case reports, brief communications, letters to the editor and invited review articles in the field of gastroenterology. The Journal is operated by internationally renowned editorial boards and designed to provide a global opportunity to promote academic developments in the field of gastroenterology and hepatology. Gut and Liver is jointly owned and operated by 8 affiliated societies in the field of gastroenterology, namely: the Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, the Korean College of Helicobacter and Upper Gastrointestinal Research, the Korean Association for the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, the Korean Pancreatobiliary Association, and the Korean Society of Gastrointestinal Cancer.
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