{"title":"用IDAC和OLINDA估计18F-FDG和68Ga-PSMA PET/CT程序的有效剂量。","authors":"Fatma Hilal Bikirli, Nesrin Altinsoy, Türkay Toklu","doi":"10.1097/HP.0000000000002034","DOIUrl":null,"url":null,"abstract":"<p><strong>Abstract: </strong>Internal dosimetry is a part of radiation safety for patients and radiation workers in nuclear medicine procedures. This study retrospectively determined the effective dose for oncology patients undergoing PET/CT scans by using widely used computer codes, and the results were compared with each other and literature. The study focused on the radiopharmaceuticals 18F-FDG (n = 220) and 68Ga-PSMA (n = 85), administered to 305 patients for cancer imaging at Yeditepe University Kosuyolu Hospital's nuclear medicine department. PET dose was calculated using OLINDA/EXM, IDAC-Dose 1.0 and IDAC-Dose 2.1 programs while ImPACT software was used to determine the effective dose from the CT scan. All effective doses were derived in accordance with ICRP 60 and ICRP 103 tissue weighting factors. PET effective doses from highest to lowest were calculated with OLINDA/EXM, IDAC-Dose 1.0, IDAC-Dose 2.1 (ICRP 60) and IDAC-Dose 2.1 (ICRP 103) as 9.96, 9.07, 7.01, 6.28 mSv respectively for 18F-FDG. The highest PET effective dose was also calculated with OLINDA/EXM software as 3.65 mSv for 68Ga-PSMA. For the total effective dose in PET/CT scans, CT contributed about 92% for 68Ga-PSMA protocol and 75% for 18F-FDG protocol.Key words: effective dose; internal dosimetry; 18F-FDG; 68Ga-PSMA; OLINDA/EXM; IDAC Dose 2.1; IDAC-Dose 1.0; PET/CT.</p>","PeriodicalId":12976,"journal":{"name":"Health physics","volume":" ","pages":""},"PeriodicalIF":1.4000,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effective Dose Estimation with IDAC and OLINDA for 18F-FDG and 68Ga-PSMA PET/CT Procedures.\",\"authors\":\"Fatma Hilal Bikirli, Nesrin Altinsoy, Türkay Toklu\",\"doi\":\"10.1097/HP.0000000000002034\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Abstract: </strong>Internal dosimetry is a part of radiation safety for patients and radiation workers in nuclear medicine procedures. This study retrospectively determined the effective dose for oncology patients undergoing PET/CT scans by using widely used computer codes, and the results were compared with each other and literature. The study focused on the radiopharmaceuticals 18F-FDG (n = 220) and 68Ga-PSMA (n = 85), administered to 305 patients for cancer imaging at Yeditepe University Kosuyolu Hospital's nuclear medicine department. PET dose was calculated using OLINDA/EXM, IDAC-Dose 1.0 and IDAC-Dose 2.1 programs while ImPACT software was used to determine the effective dose from the CT scan. All effective doses were derived in accordance with ICRP 60 and ICRP 103 tissue weighting factors. PET effective doses from highest to lowest were calculated with OLINDA/EXM, IDAC-Dose 1.0, IDAC-Dose 2.1 (ICRP 60) and IDAC-Dose 2.1 (ICRP 103) as 9.96, 9.07, 7.01, 6.28 mSv respectively for 18F-FDG. The highest PET effective dose was also calculated with OLINDA/EXM software as 3.65 mSv for 68Ga-PSMA. For the total effective dose in PET/CT scans, CT contributed about 92% for 68Ga-PSMA protocol and 75% for 18F-FDG protocol.Key words: effective dose; internal dosimetry; 18F-FDG; 68Ga-PSMA; OLINDA/EXM; IDAC Dose 2.1; IDAC-Dose 1.0; PET/CT.</p>\",\"PeriodicalId\":12976,\"journal\":{\"name\":\"Health physics\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2025-08-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Health physics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1097/HP.0000000000002034\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Health physics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/HP.0000000000002034","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
Effective Dose Estimation with IDAC and OLINDA for 18F-FDG and 68Ga-PSMA PET/CT Procedures.
Abstract: Internal dosimetry is a part of radiation safety for patients and radiation workers in nuclear medicine procedures. This study retrospectively determined the effective dose for oncology patients undergoing PET/CT scans by using widely used computer codes, and the results were compared with each other and literature. The study focused on the radiopharmaceuticals 18F-FDG (n = 220) and 68Ga-PSMA (n = 85), administered to 305 patients for cancer imaging at Yeditepe University Kosuyolu Hospital's nuclear medicine department. PET dose was calculated using OLINDA/EXM, IDAC-Dose 1.0 and IDAC-Dose 2.1 programs while ImPACT software was used to determine the effective dose from the CT scan. All effective doses were derived in accordance with ICRP 60 and ICRP 103 tissue weighting factors. PET effective doses from highest to lowest were calculated with OLINDA/EXM, IDAC-Dose 1.0, IDAC-Dose 2.1 (ICRP 60) and IDAC-Dose 2.1 (ICRP 103) as 9.96, 9.07, 7.01, 6.28 mSv respectively for 18F-FDG. The highest PET effective dose was also calculated with OLINDA/EXM software as 3.65 mSv for 68Ga-PSMA. For the total effective dose in PET/CT scans, CT contributed about 92% for 68Ga-PSMA protocol and 75% for 18F-FDG protocol.Key words: effective dose; internal dosimetry; 18F-FDG; 68Ga-PSMA; OLINDA/EXM; IDAC Dose 2.1; IDAC-Dose 1.0; PET/CT.
期刊介绍：
Health Physics, first published in 1958, provides the latest research to a wide variety of radiation safety professionals including health physicists, nuclear chemists, medical physicists, and radiation safety officers with interests in nuclear and radiation science. The Journal allows professionals in these and other disciplines in science and engineering to stay on the cutting edge of scientific and technological advances in the field of radiation safety. The Journal publishes original papers, technical notes, articles on advances in practical applications, editorials, and correspondence. Journal articles report on the latest findings in theoretical, practical, and applied disciplines of epidemiology and radiation effects, radiation biology and radiation science, radiation ecology, and related fields.
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