血清铁及其状态变化与死亡风险的关系:来自MJ队列的前瞻性发现。

IF 5.9 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Yunyun Liu, Chi Pang Wen, Junlong Pan, Jiameng Cui, Wanzhu Lu, Tong Sun, Xian Ning, June Han Lee, Wenyuan Li, Huakang Tu, Xifeng Wu
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引用次数: 0

摘要

先前关于血清铁水平和死亡风险的研究基于单点测量得出了不一致的结果。血清铁水平及其纵向变化如何影响全因死亡率和病因特异性死亡率仍然未知。本研究在前瞻性队列中调查了基线血清铁水平及其纵向变化与全因和病因特异性死亡率之间的关系。参与者从台湾MJ队列(1997-2007)中招募,随访至2022年12月31日。基线血清铁分为低、正常和高。根据第二次访问时的变化,参与者被进一步分类为持续正常、进展到异常、恢复正常或持续异常。采用Cox比例风险模型进行分析。在中位19.0年的随访期间,发生了33,005例死亡。完全调整后的模型显示血清铁与全因死亡率和病因特异性死亡率之间呈j型相关
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Associations of serum iron and its status change with mortality risk: prospective findings from the MJ cohort.

Previous studies on serum iron levels and mortality risk have yielded inconsistent findings based on single-point measurements. How serum iron levels and their longitudinal changes influence all-cause and cause-specific mortality remains unknown. This study investigated associations between baseline serum iron levels, their longitudinal changes, and all-cause and cause-specific mortality in a prospective cohort. Participants were recruited from the Taiwan MJ cohort (1997-2007) and followed until December 31, 2022. Baseline serum iron was categorized as low, normal, or high. Based on changes at a second visit, participants were further classified as persistent normal, progression to abnormal, reversion to normal, or persistent abnormal. Cox proportional hazard models were used for analysis. Over a median follow-up of 19.0 years, 33,005 deaths occurred. Fully adjusted models demonstrated J-shaped associations between serum iron and all-cause and cause-specific mortality (all P < 0.001), with higher all-cause mortality risks in low (HR 1.27, 95% CI [1.23, 1.31]) and high iron groups (HR 1.37, 95% CI [1.30, 1.44]). Compared to persistent normal levels, those with progression to abnormal, reversion to normal, or persistent abnormal serum iron exhibited elevated mortality risks (HRs: 1.22 [1.15, 1.30], 1.16 [1.09, 1.24], 1.49 [1.36, 1.63], respectively). Moreover, maintaining normal serum iron status alongside a healthy lifestyle exhibited the lowest mortality risks. Long term abnormal serum iron status was linked to increased mortality, which could be mitigated through lifestyle modifications, suggesting significance of serum iron monitoring and potential intervention.

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来源期刊
European Journal of Epidemiology
European Journal of Epidemiology 医学-公共卫生、环境卫生与职业卫生
CiteScore
21.40
自引率
1.50%
发文量
109
审稿时长
6-12 weeks
期刊介绍: The European Journal of Epidemiology, established in 1985, is a peer-reviewed publication that provides a platform for discussions on epidemiology in its broadest sense. It covers various aspects of epidemiologic research and statistical methods. The journal facilitates communication between researchers, educators, and practitioners in epidemiology, including those in clinical and community medicine. Contributions from diverse fields such as public health, preventive medicine, clinical medicine, health economics, and computational biology and data science, in relation to health and disease, are encouraged. While accepting submissions from all over the world, the journal particularly emphasizes European topics relevant to epidemiology. The published articles consist of empirical research findings, developments in methodology, and opinion pieces.
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