南印度恙虫病感染的危险因素:基于人群的队列研究。

IF 2.2 4区 医学 Q3 INFECTIOUS DISEASES
Wolf-Peter Schmidt, Neal Alexander, Winsley Rose, Daniel Chandramohan, Mary Cameron, Kundavaram Abhilash, Punam Mangtani, Carol Devamani
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引用次数: 0

摘要

恙虫病是一种由螨虫传播的感染,主要影响亚洲许多地区的农村人口。本队列研究探讨了不同流行水平的社会人口、行为和空间风险因素。来自印度南部泰米尔纳德邦37个村庄的2206名农村居民接受了问卷调查,并在基线和两年多的时间里每年进行血液采样,以检测血清转化。利用卫星图像进行土地利用目视分类。使用5602份基线血液样本估计当地血清患病率。在3629人年期间发生了270例血清转换(发病率78/1000,95%CI 67,91)。年龄较大与丛林斑疹伤寒相关,但经社会经济因素调整后的多变量分析结果显示年龄较大与丛林斑疹伤寒无关。相比之下,与男性相比,女性的风险增加(RR 1.4)不受混杂因素调整的影响。在多变量分析中,农业和相关户外活动与恙虫病的相关性较弱。然而,如果当地血清流行率低,农业活动与丛林斑疹伤寒密切相关,如果当地血清流行率高,则不密切相关。在高流行地区,女性的风险高于男性,而在低流行地区则不然。综上所述,农业活动与丛林斑疹伤寒关系不大。在高度流行的环境中,人类住区内的传播可能占主导地位。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Risk factors for scrub typhus infection in South India: population-based cohort study.

Scrub typhus is a mite-borne infection, largely affecting rural populations in many parts of Asia. This cohort study explored socio-demographic, behavioural, and spatial risk factors at different levels of endemicity. 2206 rural residents from 37 villages in Tamil Nadu, South India, underwent a questionnaire survey and blood sampling at baseline and annually over 2 years to detect sero-conversion. Satellite images were used for visual land use classification. Local sero-prevalence was estimated using 5602 baseline blood samples.Two hundred and seventy cases of seroconversions occurred during 3629 person-years (incidence rate 78/1000, 95%CI 67, 91). Older age was associated with scrub typhus in crude but not in multivariable analysis adjusting for socio-economic factors. By contrast, the increased risk in females compared to males (RR 1.4) was unaffected by adjusting for confounders. In multivariable analysis, agricultural and related outdoor activities were only weakly associated with scrub typhus. However, agricultural activities were strongly associated with scrub typhus if local sero-prevalence was low, but not if it was high. Females were at a higher risk than males in high-prevalence areas but not in low-prevalence areas. To conclude, agricultural activities were not strongly associated with scrub typhus. Transmission within human settlements may predominate in highly endemic settings.

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来源期刊
Epidemiology and Infection
Epidemiology and Infection 医学-传染病学
CiteScore
4.10
自引率
2.40%
发文量
366
审稿时长
3-6 weeks
期刊介绍: Epidemiology & Infection publishes original reports and reviews on all aspects of infection in humans and animals. Particular emphasis is given to the epidemiology, prevention and control of infectious diseases. The scope covers the zoonoses, outbreaks, food hygiene, vaccine studies, statistics and the clinical, social and public-health aspects of infectious disease, as well as some tropical infections. It has become the key international periodical in which to find the latest reports on recently discovered infections and new technology. For those concerned with policy and planning for the control of infections, the papers on mathematical modelling of epidemics caused by historical, current and emergent infections are of particular value.
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