Rui Zhang, Denise Pui-Chung Chan, Ngai Sze Wong, Sze Long Chung, Chi Keung Kwan, Tsz Ho Kwan, Shui Shan Lee
{"title":"男男性行为者多解剖部位人乳头瘤病毒感染的流行及基因型分布","authors":"Rui Zhang, Denise Pui-Chung Chan, Ngai Sze Wong, Sze Long Chung, Chi Keung Kwan, Tsz Ho Kwan, Shui Shan Lee","doi":"10.1017/S0950268825100472","DOIUrl":null,"url":null,"abstract":"<p><p>This study aims to estimate the prevalence of human papillomavirus (HPV) infection and describe its genotype distribution in MSM in Hong Kong. In this longitudinal study on Chinese MSM, multi-anatomic site self-sampling and testing for HPV, <i>Chlamydia trachomatis</i> (CT) and <i>Neisseria gonorrhoeae</i> (NG) were performed following survey completion at baseline and one-year follow-up. Overall, 41% (288/701) of MSM completed self-sampled HPV testing. HPV positivity was 29% (78/270) and 33% (42/127) at any anatomic site at baseline and follow-up timepoints, respectively. By anatomic site, HPV positivity was 26%-30%, 2%-4% and 0%-1% from rectal, penile, and pharyngeal specimens, respectively. The incidence of HPV infection was 21.2/100 and 18.9/100 person-years at any anatomic site and rectal site, respectively. Among 109 successfully genotyped samples, the most prevalent were HPV 6 (17%) and HPV 11 (16%), of which 60% of the genotyped samples were vaccine-preventable. Group sex engagement and less frequent condom use were positively associated with HPV infection (P<0.05). The HPV prevalence and incidence in MSM in this study is lower than in Western countries, and low-risk HPV genotypes are more prevalent. The high proportion of vaccine-preventable HPV subtypes underscores the importance of HPV vaccination in preventing infections in MSM.</p>","PeriodicalId":11721,"journal":{"name":"Epidemiology and Infection","volume":" ","pages":"e103"},"PeriodicalIF":2.2000,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12455509/pdf/","citationCount":"0","resultStr":"{\"title\":\"Prevalence and genotype distribution of human papillomavirus infection in multi-anatomic sites in men who have sex with men.\",\"authors\":\"Rui Zhang, Denise Pui-Chung Chan, Ngai Sze Wong, Sze Long Chung, Chi Keung Kwan, Tsz Ho Kwan, Shui Shan Lee\",\"doi\":\"10.1017/S0950268825100472\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>This study aims to estimate the prevalence of human papillomavirus (HPV) infection and describe its genotype distribution in MSM in Hong Kong. In this longitudinal study on Chinese MSM, multi-anatomic site self-sampling and testing for HPV, <i>Chlamydia trachomatis</i> (CT) and <i>Neisseria gonorrhoeae</i> (NG) were performed following survey completion at baseline and one-year follow-up. Overall, 41% (288/701) of MSM completed self-sampled HPV testing. HPV positivity was 29% (78/270) and 33% (42/127) at any anatomic site at baseline and follow-up timepoints, respectively. By anatomic site, HPV positivity was 26%-30%, 2%-4% and 0%-1% from rectal, penile, and pharyngeal specimens, respectively. The incidence of HPV infection was 21.2/100 and 18.9/100 person-years at any anatomic site and rectal site, respectively. Among 109 successfully genotyped samples, the most prevalent were HPV 6 (17%) and HPV 11 (16%), of which 60% of the genotyped samples were vaccine-preventable. Group sex engagement and less frequent condom use were positively associated with HPV infection (P<0.05). The HPV prevalence and incidence in MSM in this study is lower than in Western countries, and low-risk HPV genotypes are more prevalent. The high proportion of vaccine-preventable HPV subtypes underscores the importance of HPV vaccination in preventing infections in MSM.</p>\",\"PeriodicalId\":11721,\"journal\":{\"name\":\"Epidemiology and Infection\",\"volume\":\" \",\"pages\":\"e103\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-08-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12455509/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Epidemiology and Infection\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1017/S0950268825100472\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Epidemiology and Infection","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1017/S0950268825100472","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Prevalence and genotype distribution of human papillomavirus infection in multi-anatomic sites in men who have sex with men.
This study aims to estimate the prevalence of human papillomavirus (HPV) infection and describe its genotype distribution in MSM in Hong Kong. In this longitudinal study on Chinese MSM, multi-anatomic site self-sampling and testing for HPV, Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) were performed following survey completion at baseline and one-year follow-up. Overall, 41% (288/701) of MSM completed self-sampled HPV testing. HPV positivity was 29% (78/270) and 33% (42/127) at any anatomic site at baseline and follow-up timepoints, respectively. By anatomic site, HPV positivity was 26%-30%, 2%-4% and 0%-1% from rectal, penile, and pharyngeal specimens, respectively. The incidence of HPV infection was 21.2/100 and 18.9/100 person-years at any anatomic site and rectal site, respectively. Among 109 successfully genotyped samples, the most prevalent were HPV 6 (17%) and HPV 11 (16%), of which 60% of the genotyped samples were vaccine-preventable. Group sex engagement and less frequent condom use were positively associated with HPV infection (P<0.05). The HPV prevalence and incidence in MSM in this study is lower than in Western countries, and low-risk HPV genotypes are more prevalent. The high proportion of vaccine-preventable HPV subtypes underscores the importance of HPV vaccination in preventing infections in MSM.
期刊介绍:
Epidemiology & Infection publishes original reports and reviews on all aspects of infection in humans and animals. Particular emphasis is given to the epidemiology, prevention and control of infectious diseases. The scope covers the zoonoses, outbreaks, food hygiene, vaccine studies, statistics and the clinical, social and public-health aspects of infectious disease, as well as some tropical infections. It has become the key international periodical in which to find the latest reports on recently discovered infections and new technology. For those concerned with policy and planning for the control of infections, the papers on mathematical modelling of epidemics caused by historical, current and emergent infections are of particular value.